Experimental strategies in the context of COVID-19-induced anosmia: is neurodegeneration involved?

• Grant number: 20/05416-4
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2020
• End date: October 31, 2022
• Field of knowledge: Biological Sciences - Pharmacology - Neuropsychopharmacology
• Principal Investigator: Alline Cristina de Campos
• Grantee: Alline Cristina de Campos
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated researchers: Danielle Palma de Oliveira ; Davi Silveira Scomparin ; Eurico de Arruda Neto ; Francisco Silveira Guimaraes ; Karla Cristinne Mancini Costa ; Rafael Rinaldi Ferreira ; Ronaldo Bragança Martins Júnior
• Associated research grant: 15/05551-0 - Investigation of the involvement of endocannabinoid system on behavioral and plastic effects of antidepressant drugs, AP.JP

Abstract

The SARS-CoV-2 pandemic is causing the saturation of health systems worldwide mainly due to the severity of some respiratory symptoms induced by the course of the disease in some patients. However, the report of patients about the occurrence of anosmia in course of pathology has opened questions about the participation of a neural and, perhaps neurodegenerative, component of SARS-COV-2-induced pathophysiological changes. In addition to be a symptom of respiratory viral infections, anosmia has also been reported to be an early symptom of neurodegenerative disorders such as Alzheimer´s and Parkinson´s disease and multiple sclerosis. The olfactory epithelium- olfactory bulb pathway is a neurogenic niche in the adult brain which retain regenerative capacity that participates not only in sensory inputs process but also in the control of emotions and cognition. Therefore, the present study aims to study, using in vitro and in vivo strategies, the COVID-19 neuroinvasive mechanisms in the sensory olfactory system. In addition, we will characterize possible therapeutic targets and behavioral consequences of the COVID-19 infection in neural tissue. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BOLSONI, LIVIA MARIA; CRIPPA, JOSE ALEXANDRE S.; CECILIO HALLAK, JAIME EDUARDO; GUIMARAES, FRANCISCO SILVEIRA; ZUARDI, ANTONIO WALDO. The anxiolytic effect of cannabidiol depends on the nature of the trauma when patients with post-traumatic stress disorder recall their trigger event. Revista Brasileira de Psiquiatria, v. 44, n. 3, p. 10-pg., 2022-05-01. (20/05416-4, 16/01801-5, 08/09009-2)

COSTAL, KARLA C. M.; BRIGANTE, TAMIRES A. V.; FERNANDES, GABRIEL G.; SCOMPARIN, DAVI S.; SCARANTE, FRANCIELE F.; DE OLIVEIRA, DANIELLE P.; CAMPOS, ALLINE C.. Zebrafish as a translational model: an experimental alternative to study the mechanisms involved in anosmia and possible neurodegenerative aspects of COVID-19?. ENEURO, v. 8, n. 3, MAY-JUN 2021. (18/24298-2, 20/05416-4)

BOLSONI, LIVIA MARIA; CRIPPA, JOSE ALEXANDRE S.; CECILIO HALLAK, JAIME EDUARDO; GUIMARAES, FRANCISCO SILVEIRA; ZUARDI, ANTONIO WALDO. Effects of cannabidiol on symptoms induced by the recall of traumatic events in patients with posttraumatic stress disorder. Psychopharmacology, v. 239, n. 5, p. 9-pg., 2022-01-14. (20/05416-4, 08/09009-2)

JESUS, CARLOS HENRIQUE ALVES; FERREIRA, MATHEUS VINICIUS; GASPARIN, ALEXIA THAMARA; ROSA, EVELIZE STACOVIAKI; GENARO, KARINA; CRIPPA, JOSE ALEXANDRE DE SOUZA; CHICHORRO, JULIANA GEREMIAS; DA CUNHA, JOICE MARIA. Cannabidiol enhances the antinociceptive effects of morphine and attenuates opioid-induced tolerance in the chronic constriction injury model. Behavioural Brain Research, v. 435, p. 12-pg., 2022-08-26. (08/09009-2, 20/05416-4)