Advanced search
Start date
Betweenand

SARS-CoV-2 glycosylation: a blueprint structural insight for understanding COVID-19 pathogenesis

Abstract

Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) is an emerging human virus from the Coronaviridae family. SARS-CoV-2 is the etiological agent of novel pneumonia called COVID-19, coronavirus disease 2019. Due to the rapid increase in the number of cases that have affected countries, WHO declared COVID-19 outbreak an ongoing pandemic. As of April 1st, there are 750,890 confirmed cases and 36,405 deaths globally. Understanding host-virus dynamics is critical for development of prophylactic, diagnostic and therapeutic strategies and epidemiological control of COVID-19. Many features are yet to be understood on SARS-CoV-2 behavior and host response during infection, e.g. the molecular and cellular traits of severe, mild and asymptomatic infections, providing higher understanding of the pathogenesis. In this project we propose the application of proteome-wide spatial and temporal approach of SARS-CoV-2:host interaction, to be addressed in three interconnected fronts: (1) Assessment of activated signaling pathways by systematic quantitative analysis of temporal dynamics in protein and glycosylation changes during SARS-CoV-2 infection of human cells; (2) characterization of proteome and PTMs diversity of SARS-CoV-2; and (3) development of an early diagnostic and prognostic platform based on the proteomic profile of sera from patients with different clinical characteristics. The project proposed will contribute to understand the viral pathogenesis and prioritize biomarkers for rapid diagnostic tests. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (11)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MULE, SIMON NGAO; SAAD, JOYCE SILVA; FERNANDES, LIVIA ROSA; STOLF, BEATRIZ S.; CORTEZ, MAURO; PALMISANO, GIUSEPPE. Protein glycosylation inLeishmaniaspp.. MOLECULAR OMICS, v. 16, n. 5, p. 407-424, . (20/04923-0, 18/15549-1, 16/23689-2, 17/04032-5)
SUMAM DE OLIVEIRA, DAFFINY; KRONENBERGER, THALES; PALMISANO, GIUSEPPE; WRENGER, CARSTEN; DE SOUZA, EDMARCIA ELISA. Targeting SUMOylation in Plasmodium as a Potential Target for Malaria Therapy. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 11, . (18/10150-3, 20/04923-0, 19/26771-0, 20/12277-0, 17/03966-4, 18/18257-1, 18/15549-1, 15/26722-8)
DOMBROWSKI, JAMILLE GREGORIO; BARATEIRO, ANDRE; MACHADO PEIXOTO, ERIKA PAULA; CLAUDIO DA SILVA BARROS, ANDRE BOLER; DE SOUZA, RODRIGO MEDEIROS; CLARK, TAANE GREGORY; CAMPINO, SUSANA; WRENGER, CARSTEN; WUNDERLICH, GERHARD; PALMISANO, GIUSEPPE; et al. Adverse pregnancy outcomes are associated with Plasmodium vivax malaria in a prospective cohort of women from the Brazilian Amazon. PLoS Neglected Tropical Diseases, v. 15, n. 4, . (17/03966-4, 17/03939-7, 18/18257-1, 19/12068-5, 15/26722-8, 17/24267-7, 20/06747-4, 18/20468-0, 20/04923-0, 18/15549-1, 17/05782-8)
MULE, SIMON NGAO; ROSA-FERNANDES, LIVIA; COUTINHO, JOAO V. P.; GOMES, VINICIUS DE MORAIS; MACEDO-DA-SILVA, JANAINA; SANTIAGO, VERONICA FEIJOLI; QUINA, DANIEL; DE OLIVEIRA, GILBERTO SANTOS; THAYSEN-ANDERSEN, MORTEN; LARSEN, MARTIN R.; et al. Systems-wide analysis of glycoprotein conformational changes by limited deglycosylation assay. JOURNAL OF PROTEOMICS, v. 248, . (18/15549-1, 13/07937-8, 20/04923-0, 17/04032-5, 18/18257-1)
LAZARI, LUCAS CARDOSO; GHILARDI, FABIO DE ROSE; ROSA-FERNANDES, LIVIA; ASSIS, DIEGO M.; NICOLAU, JOSE CARLOS; SANTIAGO, VERONICA FEIJOLI; DALCOQUIO, TALIA FALCAO; ANGELI, CLAUDIA B.; BERTOLIN, ADRIADNE JUSTI; MARINHO, CLAUDIO R. F.; et al. Prognostic accuracy of MALDI-TOF mass spectrometric analysis of plasma in COVID-19. LIFE SCIENCE ALLIANCE, v. 4, n. 8, . (20/04705-2, 18/15549-1, 17/03966-4, 15/26722-8, 18/20468-0, 20/04923-0, 18/18257-1)
MULE, SIMON NGAO; GOMES, VINICIUS DE MORAIS; WAILEMANN, ROSANGELA A. M.; MACEDO-DA-SILVA, JANAINA; ROSA-FERNANDES, LIVIA; LARSEN, MARTIN R.; LABRIOLA, LETICIA; PALMISANO, GIUSEPPE. HSPB1 influences mitochondrial respiration in ER-stressed beta cells. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, v. 1869, n. 9, . (17/04032-5, 14/02745-6, 17/03618-6, 18/18257-1, 16/04676-7, 20/04923-0, 16/14845-0, 13/07937-8, 18/15549-1, 21/00507-4)
CARNEIRO, ANDREIA; VIANA-GOMES, DIEGO; MACEDO-DA-SILVA, JANAINA; OLIVEIRA LIMA, GISCARD HUMBERTO; MITRI, SIMONE; ALVES, SERGIO RABELLO; KOLLIARI-TURNER, ALEXANDER; ZANOTELI, EDMAR; DE AQUINO NETO, FRANCISCO RADLER; PALMISANO, GIUSEPPE; et al. Risk factors and future directions for preventing and diagnosing exertional rhabdomyolysis. Neuromuscular Disorders, v. 31, n. 7, p. 583-595, . (20/04923-0, 18/15549-1, 18/18257-1)
SOUZA JUNIOR, DOUGLAS RICARDO; MARTINS SILVA, AMANDA RIBEIRO; ROSA-FERNANDES, LIVIA; REIS, LORENNA ROCHA; ALEXANDRIA, GABRIELLY; BHOSALE, SANTOSH D.; GHILARDI, FABIO DE ROSE; DALCOQUIO, TALIA FALCAO; BERTOLIN, ADRIADNE JUSTI; NICOLAU, JOSE CARLOS; et al. HDL proteome remodeling associates with COVID-19 severity. JOURNAL OF CLINICAL LIPIDOLOGY, v. 15, n. 6, p. 796-804, . (19/25702-4, 18/18257-1, 15/26722-8, 13/07937-8, 16/00696-3, 20/04923-0, 17/07725-1, 18/15549-1)
MACEDO-DA-SILVA, JANAINA; SANTIAGO, VERONICA F.; ROSA-FERNANDES, LIVIA; MARINHO, CLAUDIO R. F.; PALMISANO, GIUSEPPE. Protein glycosylation in extracellular vesicles: Structural characterization and biological functions. Molecular Immunology, v. 135, p. 226-246, . (18/15549-1, 18/20468-0, 18/18257-1, 20/04923-0)
ROSA-FERNANDES, LIVIA; BANDEIRA, CARLA; POUR, SHAHAB ZAKI; BENEDETTI, VIVIANE DE FATIMA; FERREIRA, DANIEL; LORENZON, ALINE R.; MORELI, JUSCIELE B.; MARINHO, CLAUDIO ROMERO FARIAS; LARSEN, MARTIN R.; ZANOTTO, PAOLO; et al. The impact of Zika virus exposure on the placental proteomic profile. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, v. 1868, n. 1, . (20/04923-0, 18/18257-1)
LAZARI, LUCAS C.; ZERBINATI, RODRIGO M.; ROSA-FERNANDES, LIVIA; SANTIAGO, VERONICA FEIJOLI; ROSA, KLAISE F.; ANGELI, CLAUDIA B.; SCHWAB, GABRIELA; PALMIERI, MICHELLE; SARMENTO, DMITY J. S.; MARINHO, CLAUDIO R. F.; et al. ALDI-TOF mass spectrometry of saliva samples as a prognostic tool for COVID-1. OURNAL OF ORAL MICROBIOLOG, v. 14, n. 1, . (18/15549-1, 20/06409-1, 20/04923-0, 18/18257-1, 15/26722-8, 17/03966-4, 21/07490-0, 18/20468-0)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.