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Development of ionic liquids-based electroconductive hydrogels

Grant number: 19/15493-9
Support Opportunities:Regular Research Grants
Start date: November 01, 2020
End date: August 31, 2022
Field of knowledge:Engineering - Biomedical Engineering - Bioengineering
Agreement: CONFAP - National Council of State Research Support Foundations
Principal Investigator:Valéria de Carvalho Santos Ebinuma
Grantee:Valéria de Carvalho Santos Ebinuma
Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Associated researchers:Cassamo Ussemane Mussagy ; Fernando Lucas Primo ; Jania Betania Alves da Silva

Abstract

Conventional methods for obtaining electroconductive hydrogels by the incorporation of nanomaterials and conducting polymers present great technical limitations. These are mainly associated with cytotoxicity as well as low solubility, processability and biodegradability. In this project, we propose a strategy for obtaining hydrogels by the functionalization of non-conductive polymers with conductive and non-toxic ionic liquids derived from imidazole and choline. In addition to structurally characterizing hydrogels, we will determine their electroconductive and mechanical properties as well as pore size, degree of swelling and degradation. Additionally, the objective of this project is the biological characterization of these hydrogels, since they can be used in many biomedical applications. Cytotoxic properties, cell adhesion, growth and differentiation will be determined in the presence of hydrogels. Synthesis and molecular characterization of the hydrogels will be done by the team of the RS and the characterization of the electroconductive, mechanical properties, and the determination of pore size, degree of swelling, degradation will be performed by the team of São Paulo. The determination of the biological properties will be determined jointly by the two teams and collaborators. Considering the main objectives of this work, the expected results are classified in results of scientific production, training of human resources, and attendance to the interests of society. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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Scientific publications (20)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MUSSAGY, CASSAMO U.; SILVA, PEDRO G. P.; AMANTINO, CAMILA F.; BURKERT, JANAINA F. M.; PRIMO, FERNANDO L.; PESSOA, ADALBERTO, JR.; SANTOS-EBINUMA, VALERIA C.. Production of natural astaxanthin by Phaffia rhodozyma and its potential application in textile dyeing. Biochemical Engineering Journal, v. 187, p. 10-pg., . (19/15493-9, 21/06686-8, 20/08655-0)
DOS REIS, BIANCA DALBEM; DE OLIVEIRA, FERNANDA; SANTOS-EBINUMA, VALERIA C.; FILLETTI, ERICA REGINA; NETO, ALVARO DE BAPTISTA. Assessment of artificial neural networks to predict red colorant production by Talaromyces amestolkiae. Bioprocess and Biosystems Engineering, v. 46, n. 1, p. 10-pg., . (14/01580-3, 19/15493-9, 21/06686-8, 21/09175-4)
VERISSIMO, NATHALIA VIEIRA; MUSSAGY, CASSAMO USSEMANE; OSHIRO, ARIANE ALVES; NOBREGA MENDONCA, CARLOS MIGUEL; SANTOS-EBINUMA, VALERIA DE CARVALHO; PESSOA JUNIOR, ADALBERTO; DE SOUZA OLIVEIRA, RICARDO PINHEIRO; BRANDAO PEREIRA, JORGE FERNANDO. From green to blue economy: Marine biorefineries for a sustainable ocean-based economy. GREEN CHEMISTRY, v. 23, n. 23, . (18/06908-8, 20/13271-6, 20/14144-8, 19/15493-9, 18/25511-1, 20/08655-0)
MUSSAGY, CASSAMO U.; SANTOS-EBINUMA, VALERIA C.; HERCULANO, RONDINELLI D.; COUTINHO, JOAO A. P.; PEREIRA, JORGE F. B.; PESSOA JR, ADALBERTO. Ionic liquids or eutectic solvents? Identifying the best solvents for the extraction of astaxanthin and beta-carotene from Phaffia rhodozyma yeast and preparation of biodegradable films. GREEN CHEMISTRY, v. 24, n. 1, . (19/15493-9, 15/11759-3, 18/06908-8, 20/08655-0)
REMONATTO, DANIELA; FERRARI, BARBARA RIBEIRO; BASSAN, JULIANA CRISTINA; MUSSAGY, CASSAMO USSEMANE; SANTOS-EBINUMA, VALERIA DE CARVALHO; DE PAULA, ARIELA VELOSO. Utilization of Clay Materials as Support for Aspergillus japonicus Lipase: An Eco-Friendly Approach. CATALYSTS, v. 11, n. 10, . (19/15493-9, 20/08655-0, 18/06908-8, 20/09592-1, 17/11482-7)
MUSSAGY, CASSAMO U.; DOS SANTOS, AMANDA; MILITAO, GABRIELY F. G.; DE OLIVEIRA, JESSICA CAROLINA SILVA; UMBUZEIRO, GISELA DE A.; PEIXOTO, GUILHERME; PESSOA JR, ADALBERTO; SANTOS-EBINUMA, VALERIA C.. Phaffia rhodozyma biorefinery: A sustainable pathway to obtain natural pigments and production of methane biogas as renewable fuel. CHEMICAL ENGINEERING JOURNAL, v. 473, p. 12-pg., . (21/06686-8, 20/08655-0, 19/15493-9, 20/04628-8)
FARIAS, FABIANE O.; HIJO, ARIEL A. C. TOLEDO; MUSSAGY, CASSAMO U.; FERREIRA, RAMON S. B.; SANTOS-EBINUMA, VALERIA C.; BATISTA, EDUARDO A. C.; MEIRELLES, ANTONIO J. A.. Exploring the potential of naturally-derived ionic liquids for sustainable vegetable oil deacidification. FOOD AND BIOPRODUCTS PROCESSING, v. 141, p. 10-pg., . (21/04178-5, 14/21252-0, 19/15493-9, 20/08655-0, 19/18608-1, 22/04614-2)
MUSSAGY, CASSAMO U.; PEREIRA, JORGE F. B.; SANTOS-EBINUMA, VALERIA C.; PESSOA, ADALBERTO, JR.; RAGHAVAN, VIJAYA. Insights into using green and unconventional technologies to recover natural astaxanthin from microbial biomass. CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, v. N/A, p. 15-pg., . (21/06686-8, 20/08655-0, 19/15493-9)
BARBIERI, GIORGIA S.; BENTO, HEITOR B. S.; DE OLIVEIRA, FERNANDA; PICHELI, FLAVIO P.; DIAS, LIDIA M.; MASARIN, FERNANDO; SANTOS-EBINUMA, VALERIA C.. Xylanase Production by Talaromyces amestolkiae Valuing Agroindustrial Byproducts. BIOTECH, v. 11, n. 2, p. 12-pg., . (14/01580-3, 19/15493-9, 18/06908-8, 21/06686-8, 20/15513-7)
MUSSAGY, CASSAMO U.; REMONATTO, DANIELA; PICHELI, FLAVIO P.; V. PAULA, ARIELA; HERCULANO, RONDINELLI D.; SANTOS-EBINUMA, VALERIA C.; FARIAS, RENAN L.; ONISHI, BRUNO S. D.; RIBEIRO, SIDNEY J. L.; PEREIRA, JORGE F. B.; et al. A look into Phaffia rhodozyma biorefinery: From the recovery and fractionation of carotenoids, lipids and proteins to the sustainable manufacturing of biologically active bioplastics. Bioresource Technology, v. 362, p. 11-pg., . (19/15493-9, 20/08655-0, 21/06686-8)
VERISSISMO, NATHALIA V.; NAKAMURA, CECILIA NAOMI; DE OLIVEIRA, FERNANDA; KUHN, BRUNA L.; FRIZZO, CLARISSA P.; PEREIRA, JORGE F. B.; SANTOS-EBINUMA, VALERIA C.. Effect of amphiphilic ionic liquids on the colorimetric properties of polyketides colorants. JOURNAL OF MOLECULAR LIQUIDS, v. 363, p. 11-pg., . (14/01580-3, 14/16424-7, 21/09175-4, 19/15493-9, 21/06686-8)
VERISSIMO, NATHALIA VIEIRA; VICENTE, FILIPA A.; DE OLIVEIRA, RODRIGO CARDOSO; LIKOZAR, BLAZ; OLIVEIRA, RICARDO PINHEIRO DE SOUZA; PEREIRA, JORGE FERNANDO BRANDAO. Ionic liquids as protein stabilizers for biological and biomedical applications: A review. BIOTECHNOLOGY ADVANCES, v. 61, p. 29-pg., . (18/25511-1, 19/15493-9, 20/14144-8, 20/10676-5, 18/06908-8)
LIMA, CAIO A.; BENTO, HEITOR B. S.; PICHELI, FLAVIO P.; PAZ-CEDENO, FERNANDO R.; MUSSAGY, CASSAMO U.; MASARIN, FERNANDO; ACOSTA, MARIO A. TORRES; SANTOS-EBINUMA, VALERIA C.. Process development and techno-economic analysis of co- production of colorants and enzymes valuing agro-industrial citrus waste. SUSTAINABLE CHEMISTRY AND PHARMACY, v. 35, p. 13-pg., . (21/06686-8, 14/01580-3, 19/15493-9, 21/09175-4)
MUSSAGY, CASSAMO U.; KURNIA, KIKI A.; DIAS, ANA C. R. V.; RAGHAVAN, VIJAYA; SANTOS-EBINUMA, VALERIA C.; PESSOA JR, ADALBERTO. n eco-friendly approach for the recovery of astaxanthin and 8-carotene from Phaffia rhodozyma biomass using bio-based solvent. Bioresource Technology, v. 345, . (20/08655-0, 19/15493-9, 18/06908-8, 21/06686-8)
MUSSAGY, CASSAMO U.; RIBEIRO, HELENA F.; SANTOS-EBINUMA, VALERIA C.; SCHUUR, BOELO; PEREIRA, JORGE F. B.. Rhodotorula sp.-based biorefinery: a source of valuable biomolecules. Applied Microbiology and Biotechnology, v. 106, n. 22, p. 17-pg., . (19/15493-9, 21/06686-8, 20/08655-0)
MUSSAGY, CASSAMO U.; FARIAS, FABIANE O.; BILA, NIURA M.; GIANNINI, MARIA J. S. M.; PEREIRA, JORGE F. B.; SANTOS-EBINUMA, VALERIA C.; PESSOA JR, ADALBERTO. Recovery of beta-carotene and astaxanthin from Phaffia rhodozyma biomass using aqueous solutions of cholinium-based ionic liquids. Separation and Purification Technology, v. 290, p. 11-pg., . (21/06686-8, 19/15493-9, 20/08655-0)
MUSSAGY, CASSAMO U.; OSHIRO, ARIANE A.; LIMA, CAIO A.; AMANTINO, CAMILA F.; PRIMO, FERNANDO L.; SANTOS-EBINUMA, VALERIA C.; HERCULANO, RONDINELLI D.. Natural fluorescent red colorants produced by Talaromyces amestolkiae as promising coloring agents for custom-made latex gloves. JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v. 119, p. 10-pg., . (11/17411-8, 20/08655-0, 19/15493-9, 21/06686-8, 14/17526-8)
DE OLIVEIRA, FERNANDA; ZAPATA-BOADA, SANTIAGO; DA SILVA, S. S.; CUELLAR-FRANCA, ROSA M.; SANTOS-EBINUMA, VALERIA C.. Improving the Environmental Sustainability of Polyketides Colorants Production by Talaromyces Strain through Better Hydrodynamic Design in Bioreactors. ACS SUSTAINABLE CHEMISTRY & ENGINEERING, v. N/A, p. 15-pg., . (14/01580-3, 21/09175-4, 16/10636-8, 19/15493-9, 21/06686-8)
NAKAMURA, CECILIA NAOMI; PORPHIRIO VERISSIMO, NATHALIA VIEIRA; OLIVEIRA, FERNANDA; FRIZZO, CLARISSA P.; PEREZ-SANCHEZ, GERMAN; COUTINHO, JOAO A. P.; PEREIRA, JORGE F. B.; SANTOS-EBINUMA, VALERIA G.. Extraction of natural colorants using supramolecular solvents composed of Triton X-114 and ionic liquids. Separation and Purification Technology, v. 319, p. 10-pg., . (21/06686-8, 19/15493-9, 21/09175-4, 14/16424-7)
DE OLIVEIRA, FERNANDA; ROCHA, INES L. D.; GOUVEIA ALVES PINTO, DIANA CLAUDIA; VENTURA, SONIA P. M.; DOS SANTOS, ANDRE GONZAGA; CREVELIN, EDUARDO JOSE; SANTOS EBINUMA, VALERIA DE CARVALHO. Identification of azaphilone derivatives of Monascus colorants from Talaromyces amestolkiae and their halochromic properties. Food Chemistry, v. 372, . (14/01580-3, 18/06908-8, 19/15493-9)