Antimicrobial peptides and neuroinflammation: characterization of short and long term cell response

• Grant number: 20/03905-8
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2021
• End date: January 31, 2023
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Fabiano Pinheiro da Silva
• Grantee: Fabiano Pinheiro da Silva
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• City of the host institution: São Paulo

Abstract

Antimicrobial peptides (AMPs) are molecules that perform a wide range of functions in the immune response, but their mechanisms of action remain poorly understood. In addition to its direct microbicidal activity, several effects on the innate and acquired immunity under different pathological conditions have been widely described. Our group, however, has shown that depending on the underlying disease and the cellular context, antimicrobial peptides are able to exert completely opposite effects. In order to better understand this fact in the brain, we intend to induce systemic inflammatory damage by sepsis and chronic ethanol intake in wild and CRAMP deficient animals, an antimicrobial peptide that has been widely studied in recent decades in order to investigate the impact of these neuroinflammation models in the short and long term immune inflammatory response. In addition, the impact of the brain-intestinal axis will also be investigated in this scenario. This project will give rise to the PhD theses of my students Ewerton Vinicius Macarini Bruzaferro, Neusa Maria Nascimento Pimentel and Ismael Perez Flores. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PINHEIRO DA SILVA, FABIANO; GONCALVES, ANDRE NICOLAU AQUIME; DUARTE-NETO, AMARO NUNES; DIAS, THOMAZ LUESCHER; BARBEIRO, HERMES VIEIRA; BREDA, CRISTIANE NAFFAH SOUZA; BREDA, LEANDRO CARVALHO DANTAS; CAMARA, NIELS OLSEN SARAIVA; NAKAYA, HELDER I.. Transcriptome analysis of six tissues obtained post-mortem from sepsis patients. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, v. N/A, p. 11-pg., 2023-09-20. (20/03905-8)

DA SILVA, FABIANO PINHEIRO. Transcriptomics in Human Septic Shock: State of the Art. SURGICAL INFECTIONS, v. N/A, p. 8-pg., 2024-12-26. (20/03905-8)

BRUZAFERRO, EWERTON VINICIUS MACARINI; DE LIMA, THAIS MARTINS; ARIGA, SUELY KUBO; BARBEIRO, DENISE FREDIANI; BARBEIRO, HERMES VIEIRA; DA SILVA, FABIANO PINHEIRO. Effects of CRAMP on the gut-brain axis in experimental sepsis. Immunology Letters, v. 269, p. 6-pg., 2024-08-20. (20/03905-8)