Autonomic (sympathetic and parasympathetic) modulation of cardiovascular and inflammatory responses under physiopathological clinical and experimental conditions

• Grant number: 20/06043-7
• Support Opportunities: Research Projects - Thematic Grants
• Start date: May 01, 2021
• End date: April 30, 2026
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Helio Cesar Salgado
• Grantee: Helio Cesar Salgado
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• City of the host institution: Ribeirão Preto
• Principal investigators: Cláudia Helena Lovato da Silva ; Michel Reis Messora ; Rubens Fazan Junior
• Associated researchers: Adriana Barbosa Ribeiro ; Adriana Campos Passanezi Santana ; Alexandre Kanashiro ; Aline Barbosa Ribeiro ; Carlos Augusto Fernandes Molina ; Carlos Ferreira dos Santos ; Elen Rizzi Sanchez ; Fábio Nelson Gava ; Heloísa Della Coletta Francescato ; José Carlos Farias Alves Filho ; Juliana Pfrimer Falcão ; Marcus Vinicius Simões ; Marina de Toledo Durand ; Michel Reis Messora ; Minna Moreira Dias Romano ; Renata Maria Lataro ; Sandra Yasuyo Fukada Alves ; Silvia Carolina Guatimosim Fonseca ; Terezila Machado Coimbra
• Associated scholarship(s): 23/17746-7 - Relationship among Denture Stomatitis (DS), microbial load and expression of virulence genes with cardiovascular risk: observational cross-sectional study, BP.DR; 24/01181-3 - Experimental Subproject 3: Investigation of the physiopathological cardiocirculatory and inflammatory mechanisms in rats with stomatitis., BP.PD; 22/07579-3 - Experimental periodontitis in genetically modified mice (VAChT and Super VAChT): cardiovascular and inflammatory aspects, BP.PD; + associated scholarships 22/11004-6 - INFLAMMATORY AND CARDIOCIRCULATORY RESPONSES IN EXPERIMENTAL STOMATITIS, BP.IC; 22/05983-1 - Autonomic modulation - sympathy and parasympathic in: chronic Periodontitis investigated by variations in cardiac frequency, BP.DD; 22/04995-6 - Relationship of prevalence, microbial load of Candida species and degree of denture-related stomatitis with heart risk., BP.IC; 22/00203-8 - Effect of doxycycline on cardiocirculatory autonomic control in heart failure induced by myocardial infarction in rats, BP.IC; 21/08622-7 - Inflammatory and cardiovascular responses in Experimental Periodontitis, using the bilateral ligation of the first mandibular molar, in Spontaneously Hypertensive Rats (SHR), BP.PD; 21/06988-4 - Relation of the Denture Stomatits (DRS) with cardiovascular risk and the effect of denture disinfection compared to local treatment on DRS remission and cardiac risk: controlled, randomized, double-blind clinical trial, BP.PD - associated scholarships

Abstract

The Autonomic Nervous System (ANS) - Sympathetic and Parasympathetic - plays a role in the physiopathogenesis of cardiovascular diseases. Overall, there is a Sympathetic Overactivity contrasting with the Attenuation of Parasympathetic Function. It has also been demonstrated an interaction between the ANS and the Immune Systems (Innate and Adaptive), despite the mechanisms involved require more conspicuous examination. Besides, the interaction between the ANS and the Immune Systems (Innate and Adaptive) in the physiopathogenesis of Stomatitis and Periodontitis remains uncertain. To develop Experimental (Myocardial Infarction, Arterial Hypertension, Heart Failure, Periodontitis, and Stomatitis) and Clinical (Periodontitis and Stomatitis) protocols, with the purpose to better characterize the interaction of the ANS and the Immune Systems (Innate and Adaptive), and their causal relationship. Experimentally, it will be used rats (Wistar, Sprague-Dawley and Spontaneously Hypertensive Rats (SHR) and mice with attenuation (VAChT KD) or overexpression (Super VAChT) of the vesicular acetylcholine transporter. Clinically, it will be studied Patients with Periodontitis or Stomatitis. (AU)

Scientific publications

(23)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

CAVALHEIRO, ROLLSSMAN; BROGNARA, FERNANDA; DA SILVA, CARLOS ALBERTO AGUIAR; CASTANIA, JACI; SALGADO, HELIO. Physiopathological Mechanisms of Type 1 Cardiorenal Syndrome Induced by Acute Myocardial Infarction. PHYSIOLOGY, v. 39, p. 2-pg., 2024-05-01. (20/06043-7)

RIBEIRO, ALINE BARBOSA; DA SILVA, THAIS MARQUES; SANTOS-JUNIOR, NILTON NASCIMENTO; CASTANIA, JACI AIRTON; FAZAN, JR., RUBENS; SALGADO, HELIO CESAR. Short-term effect of ligature-induced periodontitis on cardiovascular variability and inflammatory response in spontaneously hypertensive rats. BMC ORAL HEALTH, v. 21, n. 1, OCT 11 2021. (18/20939-3, 18/10455-9, 20/06043-7)

DE OLIVEIRA CAVALHEIRO, ROLLSSMAN; BROGNARA, FERNANDA; DA SILVA, CARLOS ALBERTO AGUIAR; CASTANIA, JACI AIRTON; MOLINA, CARLOS AUGUSTO FERNANDES; MURPHY, DAVID; ROMANO, MINNA MOREIRA DIAS; SALGADO, HELIO CESAR. Activation of the Carotid Sinus Nerve After Acute Myocardial Infarction in a Cardiorenal Syndrome Type 1 Model in Sprague-Dawley Rats. ACTA PHYSIOLOGICA, v. 241, n. 8, p. 16-pg., 2025-08-01. (20/06043-7, 21/03764-8)

FIFOLATO, MARCO AURELIO; CLEMENTE, LORENA MOSCONI; RIBEIRO, ADRIANA BARBOSA; OLIVEIRA, VIVIANE DE CASSIA; SALGADO, HELIO CESAR; WATANABE, EVANDRO; DA SILVA, CLAUDIA HELENA LOVATO. Candida spp. in Denture Stomatitis: Prevalence, Microbial Load, and Antifungal Resistance Across Severity Levels. MICROORGANISMS, v. 13, n. 9, p. 15-pg., 2025-09-04. (22/04995-6, 20/06043-7)

SOARES, JEFFERSON ICARO; DA SILVA, THAIS MARQUES; CASTANIA, JACI AIRTON; REIS, ULISSES AVILA; ROQUE, LUIZ FELIPE MOREIRA; RIBEIRO, ADRIANA BARBOSA; SALGADO, HELIO CESAR; RIBEIRO, ALINE BARBOSA. Electrical carotid sinus nerve stimulation attenuates experimental colitis induced by acetic acid in rats. Life Sciences, v. 335, p. 8-pg., 2023-11-22. (20/08221-0, 20/06043-7)

CLEMENTE, LORENA MOSCONI; RIBEIRO, ADRIANA BARBOSA; FORTES, CAROLINE VIEIRA; RIBEIRO, ALINE BARBOSA; OLIVEIRA, VIVIANE DE CASSIA; MACEDO, ANA PAULA; SALGADO, HELIO CESAR; DA SILVA, CLAUDIA HELENA LOVATO. Risk factors and immunological biomarkers in denture stomatitis: An observational cross-sectional study. ARCHIVES OF ORAL BIOLOGY, v. 155, p. 9-pg., 2023-09-04. (20/06043-7)

DE ALMEIDA, CAMILA WALL; SILVA, CARLOS; FAZAN, RUBENS, JR.; DA SILVA, LUIZ EDUARDO VIRGILIO. Effects of Donepezil on Nonlinear Arterial Pressure and Pulse Interval Dynamics in Spontaneously Hypertensive Rats (SHR). PHYSIOLOGY, v. 39, p. 2-pg., 2024-05-01. (20/06043-7)

RIBEIRO, ADRIANA BARBOSA; PIZZIOLO, PILLAR GONCALVES; CLEMENTE, LORENA MOSCONI; AGUIAR, HELENA CRISTINA; POKER, BEATRIZ DE CAMARGO; SILVA, ARTHUR AUGUSTO MARTINS E; MAKRAKIS, LAIS RANIERI; FIFOLATO, MARCO AURELIO; SOUZA, GIULIA CRISTINA; OLIVEIRA, VIVIANE DE CASSIA; et al. Strategies for Preventing and Treating Oral Mucosal Infections Associated with Removable Dentures: A Scoping Review. ANTIBIOTICS-BASEL, v. 13, n. 3, p. 25-pg., 2024-03-01. (20/06043-7)

SANTOS, P. S.; PEREIRA JUNIOR, J. L.; ARAUJO, S. S. P.; DA SILVA, J. A.; DA SILVA, A. F. M.; DE ASSUNCAO, J. G. V.; SILVA, R. G.; DE OLIVEIRA, A. A.; NUNES, F. V. S.; NOLETO, M. S.; et al. Comparative analysis of autonomic effects of ketamine-xylazine in normotensive and hypertensive rats. Brazilian Journal of Medical and Biological Research, v. 58, p. 8-pg., 2025-01-01. (20/06043-7)

RIBEIRO, ADRIANA BARBOSA; RIBEIRO, ALINE BARBOSA; DE ARAUJO, CAMILA BORBA; FORTES, CAROLINE VIEIRA; CLEMENTE, LORENA MOSCONI; OLIVEIRA PARANHOS, HELENA DE FREITAS; WATANABE, EVANDRO; SALGADO, HELIO CESAR; SILVA-LOVATO, CLAUDIA HELENA. Effect of a Hygiene Protocol on Denture-Related Stomatitis Remission, Local Inflammatory Factors, and Hemodynamic Responses by Arterial Pressure. ANTIBIOTICS-BASEL, v. 11, n. 10, p. 13-pg., 2022-10-01. (20/06043-7, 21/06988-4)

ELEONORA NARDI CAMPOS; LORENA MOSCONI CLEMENTE; PILLAR GONÇALVES PIZZIOLO; VIVIANE DE CÁSSIA OLIVEIRA; ANA PAULA MACEDO; EVANDRO WATANABE; CLÁUDIA HELENA SILVA-LOVATO; ADRIANA BARBOSA RIBEIRO. Relation between the risk factors for the severity of denture stomatitis and quality of life of complete edentulous individuals: a cross-sectional study. Journal of Applied Oral Science, v. 31, 2023-12-18. (21/06988-4, 20/06043-7)

DOS SANTOS, RAFAEL RODRIGUES; MARUMO, MATHEO BELLINI; ECKELI, ALAN LUIZ; SALGADO, HELIO CESAR; SILVA, LUIZ EDUARDO VIRGILIO; TINOS, RENATO; FAZAN JR, RUBENS. The use of heart rate variability, oxygen saturation, and anthropometric data with machine learning to predict the presence and severity of obstructive sleep apnea. FRONTIERS IN CARDIOVASCULAR MEDICINE, v. 12, p. 10-pg., 2025-03-14. (20/06043-7)

DA SILVA, FERNANDA STABILE; BONIFACIO, LIVIA PIMENTA; BELLISSIMO-RODRIGUES, FERNANDO; JOAQUIM, LUIS FERNANDO; DIAS, DANIEL PENTEADO MARTINS; ROMANO, MINNA MOREIRA DIAS; SCHMIDT, ANDRE; CRESCENCIO, JULIO CESAR; BUZINARI, TEREZA C.; FAZAN JR, RUBENS; et al. Investigating autonomic nervous system dysfunction among patients with post-COVID condition and prolonged cardiovascular symptoms. FRONTIERS IN MEDICINE, v. 10, p. 13-pg., 2023-10-09. (20/06043-7, 21/03764-8)

SALGADO, HELIO CESAR; BROGNARA, FERNANDA; RIBEIRO, ALINE BARBOSA; LATARO, RENATA MARIA; CASTANIA, JACI AIRTON; ULLOA, LUIS; KANASHIRO, ALEXANDRE. Autonomic Regulation of Inflammation in Conscious Animals. NEUROIMMUNOMODULATION, v. 30, n. 1, p. 11-pg., 2023-01-01. (20/06043-7, 21/03764-8)

BROGNARA, FERNANDA; CASTANIA, JACI AIRTON; RIBEIRO, ALINE BARBOSA; SANTOS-JUNIOR, NILTON NASCIMENTO; SALGADO, HELIO CESAR. The Bezold-Jarisch Reflex and The Inflammatory Response Modulation in Unanesthetized Endotoxemic Rats. FRONTIERS IN PHYSIOLOGY, v. 12, SEP 20 2021. (13/20549-7, 20/06043-7, 18/10455-9, 18/20939-3, 17/05163-6)

CESARINO, LUIZ G.; BROGNARA, FERNANDA; CASTANIA, JACI A.; SALGADO, HELIO C.. Baroreflex Activation Contributes to the Progression of the Systemic Inflammatory Response in Unanesthetized Rats. FASEB JOURNAL, v. 36, p. 1-pg., 2022-01-01. (20/06043-7, 20/08312-5, 21/03764-8)

GUIMARAES, DIOGO A.; AQUINO, NAYARA S. S.; ROCHA-RESENDE, CIBELE; JESUS, ITAMAR C. G.; SILVA, MARIO MORAIS; SCALZO, SERGIO A.; FONSECA, ROBERTA CRISTELLI; DURAND, MARINA T.; PEREIRA, VANESSA; TEZINI, GEISA C. S., V; et al. Neuronal cholinergic signaling constrains norepinephrine activity in the heart. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, v. 322, n. 4, p. 8-pg., 2022-04-01. (20/06043-7)

PIZZIOLO, PILLAR GONCALVES; SILVA-LOVATO, CLAUDIA HELENA; CLEMENTE, LORENA MOSCONI; CARANDINA, ANGELICA; SALGADO, HELIO CESAR; DA SILVA, THAIS MARQUES; TOBALDINI, ELEONORA; MONTANO, NICOLA; RIBEIRO, ADRIANA BARBOSA. The role of oral microbiota and tooth loss in cardiovascular disease risk: a systematic review. BIOFOULING, v. 41, n. 7, p. 15-pg., 2025-06-07. (23/15058-6, 20/06043-7)

BROGNARA, FERNANDA; CASTANIA, JACI; DE OLIVEIRA NETO, JOSE TELES; MACHADO, MIRELE; SALGADO, HELIO; TOSTES, RITA; DIAS, DANIEL; PATON, JULIAN; CARNIO, EVELIN. Aortic Baroreceptor Afferents Express Receptors and Mediators of the Inflammatory Response. PHYSIOLOGY, v. 40, p. 2-pg., 2025-05-01. (21/03764-8, 13/08216-2, 20/06043-7, 21/05554-0, 22/13361-0)

BUZINARI, TEREZA; CASTANIA, JACI; SALVADOR, SERGIO; SALGADO, HELIO. Periodontitis accelerates the development of arterial hypertension in spontaneously hypertensive rats (SHR). PHYSIOLOGY, v. 38, p. 2-pg., 2023-05-01. (21/08622-7, 20/06043-7)

DURAND, MARINA; SANCHES, ELEN; COSTA, LUCAS; SILVA, CARLOS; BUZINARI, TEREZA; SALGADO, HELIO; FAZAN, RUBENS, JR.. Effect of doxycycline in autonomic modulation of the heart, assessed by heart rate variability, in rats with myocardial infarction. PHYSIOLOGY, v. 38, p. 2-pg., 2023-05-01. (20/06043-7)

PIZZIOLO, PILLAR GONSALVES; CLEMENTE, LORENA MOSCONI; RIBEIRO, ALINE BARBOSA; OLIVEIRA, VIVIANE DE CASSIA; MACEDO, ANA PAULA; SALGADO, HELIO CESAR; FAZAN-JUNIOR, RUBENS; WATANABE, EVANDRO; SILVA-LOVATO, CLAUDIA HELENA; RIBEIRO, ADRIANA BARBOSA. The interplay of edentulism, smoking, microbiota, oral rehabilitation on cytokineprofile and different conditions of hypertension. ARCHIVES OF ORAL BIOLOGY, v. 172, p. 8-pg., 2025-01-18. (23/15058-6, 20/06043-7)

BUZINARI, TEREZA C.; CASTANIA, JACI A.; SALVADOR, SERGIO L. S.; RIBEIRO, ALINE B.; FAZAN JUNIOR, RUBENS; SALGADO, HELIO C.. Periodontitis accelerates the onset of hypertension in spontaneously hypertensive rats, while the electrical activation of the carotid sinus nerve delays the beginning of the increase in blood pressure. Journal of Hypertension, v. 43, n. 2, p. 7-pg., 2025-02-01. (21/08622-7, 20/06043-7)