Performance improvement in Airlift internal circulation bioreactor through geometric modifications to the inner tube

• Grant number: 20/08699-7
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2021
• End date: June 30, 2023
• Field of knowledge: Engineering - Chemical Engineering - Industrial Operations and Equipment for Chemical Engineering
• Principal Investigator: Marcel Otavio Cerri
• Grantee: Marcel Otavio Cerri
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Associated researchers: Mateus Nordi Esperança

Abstract

The Airlift bioreactors are proving to be an advantageous alternative to conventional bioreactors. However, they present complex hydrodynamics, and the characterization of Airlift bioreactors is a task that has aroused a lot of interest because it allows its optimal use for various reaction conditions of microorganisms with different metabolism. The present project aims to study and make the use of new geometric configurations for Airlift bioreactors that are still little explored, proposing innovative approaches and studying kLa, gas retention and circulation velocity from the inclusion of radial promoters in the inner tube and a flow director at the top and bottom of the inner tube both to optimize mass transfer. The validation of the performance improvement will be with the cultures of Bacillus subtilis to produce riboflavin. In this context, this work has potential in the biotechnology area, generating important results for the food industry, pharmaceutical industry, among others. The implementation of the project will contribute to the development and optimization of national technologies and industrial-scale processes for the manufacture of products of economic interest, nutritional, and medicinal. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ESPERANCA, MATEUS N.; BUFFO, MARIANE M.; MENDES, CAROLINE E.; RODRIGUEZ, GUILHERME Y.; BETTEGA, RODRIGO; BADINO, ALBERTO C.; CERRI, MARCEL O.. inking maximal shear rate and energy dissipation/circulation function in airlift bioreactor. Biochemical Engineering Journal, v. 178, JAN 2022. (18/11405-5, 20/08699-7, 11/23807-1, 12/17756-8)

PICAO, BRUNO W.; GONCALVES, DANIELE O.; RIBEIRO, RENATA M. M. G. P.; ESPERANCA, MATEUS N.; PEIXOTO, GUILHERME; CERRI, MARCEL O.. Oxygen transfer and gas holdup in airlift bioreactors assembled with helical flow promoters. Bioprocess and Biosystems Engineering, v. N/A, p. 12-pg., 2023-02-20. (20/08699-7)

REMONATTO, DANIELA; SANTAELLA, NUBIA; LERIN, LINDOMAR ALBERTO; BASSAN, JULIANA CRISTINA; CERRI, MARCEL OTAVIO; DE PAULA, ARIELA VELOSO. Solvent-Free Enzymatic Synthesis of Dietary Triacylglycerols from Cottonseed Oil in a Fluidized Bed Reactor. Molecules, v. 28, n. 14, p. 18-pg., 2023-07-01. (20/09592-1, 20/08699-7)

ESPERANCA, MATEUS N.; CERRI, MARCEL O.; MAZZIERO, VITOR T.; BETTEGA, RODRIGO; BADINO, ALBERTO C.. Hydrodynamic comparison of different geometries of square cross-section airlift bioreactor using computational fluid dynamics. INTERNATIONAL JOURNAL OF CHEMICAL REACTOR ENGINEERING, v. N/A, p. 13-pg., 2023-07-07. (12/17756-8, 11/23807-1, 20/08699-7)

LINS, MILCA RACHEL DA COSTA RIBEIRO; AMORIM, LAURA ARAUJO DA SILVA; CORREA, GRACIELY GOMES; PICAO, BRUNO WILLIAN; MACK, MATTHIAS; CERRI, MARCEL OTAVIO; PEDROLLI, DANIELLE BISCARO. Targeting riboswitches with synthetic small RNAs for metabolic engineering. METABOLIC ENGINEERING, v. 68, p. 59-67, NOV 2021. (20/08699-7, 14/17564-7)