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Performance improvement in Airlift internal circulation bioreactor through geometric modifications to the inner tube

Grant number: 20/08699-7
Support type:Regular Research Grants
Duration: July 01, 2021 - June 30, 2023
Field of knowledge:Engineering - Chemical Engineering - Industrial Operations and Equipment for Chemical Engineering
Principal researcher:Marcel Otavio Cerri
Grantee:Marcel Otavio Cerri
Home Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Assoc. researchers: Mateus Nordi Esperança


The Airlift bioreactors are proving to be an advantageous alternative to conventional bioreactors. However, they present complex hydrodynamics, and the characterization of Airlift bioreactors is a task that has aroused a lot of interest because it allows its optimal use for various reaction conditions of microorganisms with different metabolism. The present project aims to study and make the use of new geometric configurations for Airlift bioreactors that are still little explored, proposing innovative approaches and studying kLa, gas retention and circulation velocity from the inclusion of radial promoters in the inner tube and a flow director at the top and bottom of the inner tube both to optimize mass transfer. The validation of the performance improvement will be with the cultures of Bacillus subtilis to produce riboflavin. In this context, this work has potential in the biotechnology area, generating important results for the food industry, pharmaceutical industry, among others. The implementation of the project will contribute to the development and optimization of national technologies and industrial-scale processes for the manufacture of products of economic interest, nutritional, and medicinal. (AU)

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