Photoacoustic and ultrasound imaging for theranostic purposes

• Grant number: 21/06728-2
• Support Opportunities: Research Grants - Young Investigators Grants - Phase 2
• Start date: February 01, 2022
• End date: January 31, 2027
• Field of knowledge: Engineering - Biomedical Engineering - Medical Engineering
• Principal Investigator: Theo Zeferino Pavan
• Grantee: Theo Zeferino Pavan
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated researchers: Ana Paula Ramos ; Antonio Adilton Oliveira Carneiro ; Luciano Bachmann ; Marcello Henrique Nogueira Barbosa ; María Sol Brassesco Annichini
• Associated research grant: 13/18854-6 - Photoacoustic and ultrasound imaging applied to tissue characterization, AP.JP
• Associated research grant(s): 22/14228-2 - Monitoring magnetic nanoparticle cell labelling with ultrasound imaging, AP.R SPRINT; 21/14775-0 - Multi-user equipment approved in grant 2021/06728-2: LED-based photoacoustic imaging system - AcousticX, AP.EMU
• Associated scholarship(s): 23/04057-9 - Combining photoacoustic and magnetomotive ultrasound imaging to improve nanoparticle detection, BP.PD; 22/08495-8 - Photoacoustic-based thermal imaging using LED illumination, BP.IC; 22/05372-2 - Development of multidomain simulations to analyse the source of artifacts in photoacoustic imaging, BP.IC; 22/01470-0 - Theranostic platform composed of magnetic hyperthermia, ultrasound and photoacoustic imaging, BP.DD

Abstract

Photoacoustic imaging, along with conventional ultrasound, is a hybrid medical imaging modality with unique characteristics. It allows obtaining both physiological events and the molecular composition of tissues together with anatomical information. During the Young Researcher Award (2013/18854-6), a research laboratory dedicated to the development of photoacoustic imaging technologies was established, where several studies have already been conducted. Spectroscopic photoacoustic images to quantify dyes, nanoparticles, and endogenous chromophores, as well as thermal images to monitor hyperthermia procedures are a couple of examples. Magnetic hyperthermia has been proposed as a promising cancer treatment modality. However, challenges such as localizing the magnetic nanoparticles within tissues and monitoring the temperature during the treatment hinder this technique to be effectively translated into a clinical routine. In this research project, platforms combining ultrasonic techniques with optics (photoacoustic imaging) and magnetism (magnetomotive ultrasound) in theranostic systems will be developed, with the objective of increasing the sensitivity to map the spatial distribution of magnetic nanoparticles and temperature during the magnetic hyperthermia procedure. The combination of these techniques will allow the assessment of other parameters such as oxygen saturation and viscoelasticity during the hyperthermia procedure. These hybrid methods will be evaluated with tissue-mimicking phantoms and with subcutaneous tumors in mice. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

HUBER, CHRISTIAN MARINUS; PAVAN, THEO Z.; ULLMANN, INGRID; HEIM, CHRISTIAN; RUPITSCH, STEFAN J.; VOSSIEK, MARTIN; ALEXIOU, CHRISTOPH; ERMERT, HELMUT; LYER, STEFAN. A Review on Ultrasound-based Methods to Image the Distribution of Magnetic Nanoparticles in Biomedical Applications. ULTRASOUND IN MEDICINE AND BIOLOGY, v. 51, n. 2, p. 25-pg., 2024-12-19. (21/06728-2, 18/16939-8)

COLLAZOS-BURBANO, DAVID A.; FREIRE, JOSE E.; SANCHES, ARIANE F.; ZUFELATO, NICHOLAS; ULIANA, JOAO H.; BRASSESCO, MARIA S.; CARNEIRO, ANTONIO A. O.; PAVAN, THEO Z.. Beyond Axial Symmetry: Tracking Vectorial Motion Enhances Nanoparticles Mapping With Magnetomotive Ultrasound. IEEE ACCESS, v. 13, p. 13-pg., 2025-01-01. (21/06728-2, 23/11602-3, 18/16939-8, 23/04056-2, 22/01470-0, 22/12771-0, 23/04057-9)

VICENTE, THIAGO T.; ARSALANI, SAEIDEH; QUIEL, MATEUS S.; FERNANDES, GUILHERME S. P.; DA SILVA, KETERYNE R.; FUKADA, SANDRA Y.; GUALDI, ALEXANDRE J.; GUIDELLI, EDER J.; BAFFA, OSWALDO; CARNEIRO, ANTONIO A. O.; et al. Improving the Theranostic Potential of Magnetic Nanoparticles by Coating with Natural Rubber Latex for Ultrasound, Photoacoustic Imaging, and Magnetic Hyperthermia: An In Vitro Study. PHARMACEUTICS, v. 16, n. 11, p. 22-pg., 2024-11-01. (18/16939-8, 21/06728-2, 13/18854-6, 17/14482-8, 13/07699-0)

ULIANA, JOAO HENRIQUE; THOMAZ SAMPAIO, DIEGO RONALDO; SANCHES, ARIANE FRANSON; PAVAN, THEO ZEFERINO; DE OLIVEIRA CARNEIRO, ANTONIO ADILTON. MUSA-WAVE: A Software Platform for Magnetomotive Ultrasound and Shear Wave Analysis. 2024 IEEE UFFC LATIN AMERICA ULTRASONICS SYMPOSIUM, LAUS, v. N/A, p. 4-pg., 2024-01-01. (22/07463-5, 21/06728-2, 18/16939-8)