| Grant number: | 20/13249-0 |
| Support Opportunities: | Regular Research Grants |
| Start date: | November 01, 2021 |
| End date: | October 31, 2025 |
| Field of knowledge: | Health Sciences - Medicine - Surgery |
| Principal Investigator: | André Roncon Dias |
| Grantee: | André Roncon Dias |
| Host Institution: | Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira (ICESP). Coordenadoria de Serviços de Saúde (CSS). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil |
| Associated researchers: | Amir Zeide Charruf ; Marcus Fernando Kodama Pertille Ramos ; Marina Alessandra Pereira ; Ulysses Ribeiro Júnior |
Abstract
Peritoneal carcinomatosis (PC) in gastric cancer (GC) is considered a fatal disease, without expectation of definitive cure. Since conventional surgery is not indicated in the palliative setting, and systemic chemotherapy treatments are not sufficient to contain the disease, a multimodal approach associating intraperitoneal (IP) chemotherapy (CT) with surgery may represent an alternative for these patients.IP CT has shown superior results to conventional treatment in patients at this stage of the disease, and can achieve complete regression of lesions in a significant portion of cases. Once response to treatment is achieved, patients become fit for curative surgery, which offers a new perspective on the survival in these previously unresectable cases, and raising survival rates to similar levels to patients undergoing surgery with curative intention. Thus, the aim of this study is to evaluate the complete response rate and curative resection in patients with PC by GC at Instituto do Câncer do Estado de São Paulo (ICESP) treated with IP CT. Patients prospectively included in the study will undergo implantation of a peritoneum catheter to perform outpatient IP CT in order to promote the regression of lesions. Those with complete regression may be referred for surgical treatment, curing a portion of these patients. The diagnosis of PC will be performed by conventional cytological, immunohistochemical and liquid cytology methods to determine the presence of tumor cells in the peritoneal lavage and to evaluate the sensitivity of the methods. In addition, it is proposed in the study the storage of material for further study of circulating markers in peripheral blood and peritoneal lavage that may be related to response or resistance to treatment. It is believed that IP CT may not only increase the survival of patients with PC, but also offer the possibility of cure for a significant portion of patients who are currently without treatment prospects and with a median survival of only six months. (AU)
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