Investigation of hybrid biomaterial chitosan/polycaprolactone intraperitoneal barrier; focus on controlled release chemotherapy

• Grant number: 13/19472-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: December 01, 2013
• End date: November 30, 2016
• Field of knowledge: Engineering - Biomedical Engineering
• Principal Investigator: Cecilia Amelia de Carvalho Zavaglia
• Grantee: Guinea Brasil Camargo Cardoso
• Host Institution: Faculdade de Engenharia Mecânica (FEM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated scholarship(s): 14/08625-2 - Detailed characterization of the hybrid biomaterial chitosan/polycaprolactone, BE.EP.PD

Abstract

The treatment of abdominal cancer presents as major complication the spread of cancer cells in the abdominal cavity causing an increase in pelvic recurrence of primary cancers, such as peritoneal carcinomatosis (PC). With this increased incidence of peritoneal carcinomatosis also increases the need for surgery in the area, causing the appearance of peritoneal adhesions. These adhesions can cause infertility, pains and blockages, and increase the risk of failure in future surgeries.Although the peritoneum has numerous functions such as promoting the secretion of peritoneal fluid, fat storage, and reduce infection in the peritoneal cavity, there are few available biomaterials for use as barrier intraperitoneally. A small variety of products approved by the FDA for use as a barrier intraperitoneal, provide no possibility of changes to controlled release of drugs, especially focusing on cases of peritoneal carcinomatosis.For this proposal the current project aims to research the biomaterial chitosan / PCL surgical barrier to prevent intraperitoneal adhesion. The biomaterial polycaprolactone appears promising modifications to the addition of drugs such as 5-fluorouracil (5-FU), a drug for topical chemotherapy using against peritoneal carcinomatosis. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CARDOSO, GUINEA B. C.; MANIGLIO, DEVID; VOLPATO, FABIO Z.; TONDON, ABHISHEK; MIGLIARESI, CLAUDIO; KAUNAS, ROLAND R.; ZAVAGLIA, CECILIA A. C.. Oleic acid surfactant in polycaprolactone/hydroxyapatite-composites for bone tissue engineering. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, v. 104, n. 6, p. 1076-1082, AUG 2016. (14/08625-2, 13/19472-0)

CAMARGO CARDOSO, GUINEA BRASIL; CHACON, ERIVELTO LUIS; BARBOSA MAIA, LUIS RICARDO; DE CARVALHO ZAVAGLIA, CECILIA AMELIA; DA CUNHA, MARCELO RODRIGUES. The Importance of Understanding Differences in a Critical Size Model: a Preliminary In Vivo Study Using Tibia and Parietal Bone to Evaluate the Reaction with Different Biomaterials. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 22, n. 1, 2019. (13/19472-0)

CARDOSO, GUINEA B. C.; CHACON, ERIVELTO; CHACON, PRISCILA G. L.; BORDEAUX-REGO, PEDRO; DUARTE, ADRIANA S. S.; OLALLA SAAD, SARA T.; ZAVAGLIA, CECILIA A. C.; CUNHA, MARCELO R.. Fatty acid is a potential agent for bone tissue induction: In vitro and in vivo approach. Experimental Biology and Medicine, v. 242, n. 18, p. 1765-1771, DEC 2017. (13/19472-0)