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Investigation of hybrid biomaterial chitosan/polycaprolactone intraperitoneal barrier; focus on controlled release chemotherapy

Grant number: 13/19472-0
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): December 01, 2013
Effective date (End): November 30, 2016
Field of knowledge:Engineering - Biomedical Engineering
Principal Investigator:Cecilia Amelia de Carvalho Zavaglia
Grantee:Guinea Brasil Camargo Cardoso
Home Institution: Faculdade de Engenharia Mecânica (FEM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated scholarship(s):14/08625-2 - Detailed characterization of the hybrid biomaterial chitosan/polycaprolactone, BE.EP.PD


The treatment of abdominal cancer presents as major complication the spread of cancer cells in the abdominal cavity causing an increase in pelvic recurrence of primary cancers, such as peritoneal carcinomatosis (PC). With this increased incidence of peritoneal carcinomatosis also increases the need for surgery in the area, causing the appearance of peritoneal adhesions. These adhesions can cause infertility, pains and blockages, and increase the risk of failure in future surgeries.Although the peritoneum has numerous functions such as promoting the secretion of peritoneal fluid, fat storage, and reduce infection in the peritoneal cavity, there are few available biomaterials for use as barrier intraperitoneally. A small variety of products approved by the FDA for use as a barrier intraperitoneal, provide no possibility of changes to controlled release of drugs, especially focusing on cases of peritoneal carcinomatosis.For this proposal the current project aims to research the biomaterial chitosan / PCL surgical barrier to prevent intraperitoneal adhesion. The biomaterial polycaprolactone appears promising modifications to the addition of drugs such as 5-fluorouracil (5-FU), a drug for topical chemotherapy using against peritoneal carcinomatosis. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CAMARGO CARDOSO, GUINEA BRASIL; CHACON, ERIVELTO LUIS; BARBOSA MAIA, LUIS RICARDO; DE CARVALHO ZAVAGLIA, CECILIA AMELIA; DA CUNHA, MARCELO RODRIGUES. The Importance of Understanding Differences in a Critical Size Model: a Preliminary In Vivo Study Using Tibia and Parietal Bone to Evaluate the Reaction with Different Biomaterials. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 22, n. 1 2019. Web of Science Citations: 0.
CARDOSO, GUINEA B. C.; CHACON, ERIVELTO; CHACON, PRISCILA G. L.; BORDEAUX-REGO, PEDRO; DUARTE, ADRIANA S. S.; OLALLA SAAD, SARA T.; ZAVAGLIA, CECILIA A. C.; CUNHA, MARCELO R. Fatty acid is a potential agent for bone tissue induction: In vitro and in vivo approach. Experimental Biology and Medicine, v. 242, n. 18, p. 1765-1771, DEC 2017. Web of Science Citations: 2.
CARDOSO, GUINEA B. C.; MANIGLIO, DEVID; VOLPATO, FABIO Z.; TONDON, ABHISHEK; MIGLIARESI, CLAUDIO; KAUNAS, ROLAND R.; ZAVAGLIA, CECILIA A. C. Oleic acid surfactant in polycaprolactone/hydroxyapatite-composites for bone tissue engineering. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, v. 104, n. 6, p. 1076-1082, AUG 2016. Web of Science Citations: 7.

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