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Detailed characterization of the hybrid biomaterial chitosan/polycaprolactone

Grant number: 14/08625-2
Support type:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): August 31, 2014
Effective date (End): August 30, 2015
Field of knowledge:Engineering - Biomedical Engineering
Principal Investigator:Cecilia Amelia de Carvalho Zavaglia
Grantee:Guinea Brasil Camargo Cardoso
Supervisor abroad: Roland Raymond Kaunas
Home Institution: Faculdade de Engenharia Mecânica (FEM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Local de pesquisa : Texas A&M University, United States  
Associated to the scholarship:13/19472-0 - Investigation of hybrid biomaterial chitosan/polycaprolactone intraperitoneal barrier; focus on controlled release chemotherapy, BP.PD


The treatment of abdominal cancer presents as major complication the spread of cancer cells into the abdominal cavity, that cause an increase in pelvic recurrence of primary cancers, such as peritoneal carcinomatosis (PC). The incidence of peritoneal carcinomatosis induces the need of surgery in the area, and unfortunately that causes peritoneal adhesions. These adhesions can cause infertility, pains and blockages, and increase the risk of failure in future surgeries.There are some available biomaterials for use as barrier intraperitoneally. A small variety of these products are approved by the FDA for use as a barrier intraperitoneal, but they provide no possibility of changes to control the release of drugs, especially focusing cases of peritoneal carcinomatosis.For this proposal the current project aims to research the biomaterial chitosan / PCL surgical barrier to prevent intraperitoneal adhesion. This biomaterial will be characterized by MEV, contact angle, DSC, mechanical test (tensile), in vitro tests with and without stretch and in vivo assay. The major focus is to investigate this promising structure for in the future act as a drug deliver for topical chemotherapy to treat peritoneal carcinomatosis. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CARDOSO, G. B. C.; TONDON, A.; MAIA, L. R. B.; CUNHA, M. R.; ZAVAGLIA, C. A. C.; KAUNAS, R. R. In vivo approach of calcium deficient hydroxyapatite filler as bone induction factor. Materials Science & Engineering C-Materials for Biological Applications, v. 99, p. 999-1006, JUN 2019. Web of Science Citations: 0.
CARDOSO, GUINEA B. C.; MANIGLIO, DEVID; VOLPATO, FABIO Z.; TONDON, ABHISHEK; MIGLIARESI, CLAUDIO; KAUNAS, ROLAND R.; ZAVAGLIA, CECILIA A. C. Oleic acid surfactant in polycaprolactone/hydroxyapatite-composites for bone tissue engineering. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, v. 104, n. 6, p. 1076-1082, AUG 2016. Web of Science Citations: 7.

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