A novel bioglass of the SiO2 - Na2O - CaO - P2O5 system, developed from marine sponge biosilica, for use in bone tissue engineering: from conception to pre-clinical experimental application

• Grant number: 21/04957-4
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2022
• End date: August 31, 2024
• Field of knowledge: Interdisciplinary Subjects
• Principal Investigator: Renata Neves Granito
• Grantee: Renata Neves Granito
• Host Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil
• Associated researchers: Ana Claudia Muniz Renno ; Eliandra de Sousa Trichês ; Laurence Vico ; Márcio Reis Custódio ; Paula Christine Jimenez ; Yann Simon Gallot
• Associated scholarship(s): 22/06103-5 - Development and physicochemical characterization of a bioglass belonging to the quaternary system SiO2-Na2O-CaO-P2O5, using silica extracted from marine sponges., BP.TT

Abstract

The rich biological diversity of marine ecosystems makes them abundant in bioactive compounds favorable to the development of innovative biotechnological products. Several studies have shown, for example, that the biosilica extracted from marine sponges has osteogenic properties and our group have recently demonstrated that it may even have superior osteoinductive effects than those of the gold standard bioactive material, the Bioglass®45S5. In this context, this proposal aims to take advantage of the huge potential of Brazilian marine biodiversity for the development of a new bioglass from the SiO2 - Na2O - CaO - P2O5 system, using biosilica from marine sponges. From its conception to the experimental application, there will be 3 stages: (1) the development and the physical-chemical characterization of the particulate biomaterial and of 3D-printed scaffolds; (2) in vitro studies involving indirect (extracts) and direct (cell-scaffold contact) tests on osteoblast precursor cells and covering various analyzes, from the cytogenotoxicity of the biomaterial to its effects on cell metabolism and function; (3) in vivo studies with the surgical implantation of the 3D printed scaffolds in bone defects in rats. Thus, the results of these studies will provide data on the processing and the preclinical osteogenic potential of a new bioglass, which will be valuable for the development of highly effective biomaterials, in terms of quality and accessibility to the citizen, for the treatment of bone tissue disorders from the sustainable use of marine biodiversity of a planet called "blue". (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SANTOS, CINTIA P. G.; PRADO, JOAO P. S.; FERNANDES, KELLY R. R.; KIDO, HUELITON W. W.; DORILEO, BIANCA P. P.; PARISI, JULIA R. R.; SILVA, JONAS A. A.; CRUZ, MATHEUS A. A.; CUSTODIO, MARCIO R.; RENNO, ANA C. M.; et al. Different Species of Marine Sponges Diverge in Osteogenic Potential When Therapeutically Applied as Natural Scaffolds for Bone Regeneration in Rats. JOURNAL OF FUNCTIONAL BIOMATERIALS, v. 14, n. 3, p. 19-pg., 2023-03-01. (19/10228-5, 21/04957-4)