Nanomaterials combined with nitric oxide donors for biological applications

• Grant number: 22/00321-0
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2022
• End date: May 31, 2024
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Amedea Barozzi Seabra
• Grantee: Amedea Barozzi Seabra
• Host Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Santo André , SP, Brazil
• Associated researchers: Halley Caixeta de Oliveira ; Rafael Vasconcelos Ribeiro

Abstract

The free radical nitric oxide (NO) plays important actions in several biological processes in mammals, such as the control of vasodilation, immune response, cellular communication and skin healing. NO is also recognized as a key molecule in several physiological processes in plants, including dormancy breaking and seed germination, root growth, flowering, regulation of pollen tube growth, photosynthesis, control of opening and stomatal closure and responses to abiotic stresses (such as water deficit, full sun, metal toxicity, and salinity). As a free radical, NO donors are administered in several applications. Among them, S-nitrosothiols (RSNOs) stand out, which decompose spontaneously releasing NO. Works in the literature and previous works by the proponent's group revealed that the combination of nanotechnology with RSNOs represents a promising strategy to enable the therapeutic use of NO. In this context, the main objective of the project is the synthesis and characterization of nanoparticles and nanocomposites (i) based on biocompatible polymers and (ii) metal-based nanoparticles combined with NO donors for biological applications. The project also provides kinetic studies of NO release from the prepared nanomaterials, the evaluation of their cytotoxicity, including the evaluation of toxicity mechanisms, interaction of nanomaterials with cells and applications of nanomaterials in plants under abiotic stress. It is expected to contribute to the escalation of development of biocompatible materials that donate NO with great impact in biomedical applications and in agriculture, with articles and filing of patent applications. (AU)

Scientific publications

(23)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SILVA, ALINE CASTRO; DOS SANTOS, ALISSON GLEYSSON RODRIGUES; PIERETTI, JOANA CLAUDIO; ROLIM, WALLACE ROSADO; SEABRA, AMEDEA BAROZZI; AVILA, DAIANA SILVA. Iron oxide/silver hybrid nanoparticles impair the cholinergic system and cause reprotoxicity in Caenorhabditis elegans. Food and Chemical Toxicology, v. 179, p. 14-pg., 2023-09-01. (22/00321-0, 20/03646-2)

GOMES, DIEGO G. G.; DEBIASI, TATIANE V. V.; PELEGRINO, MILENA T. T.; PEREIRA, RODRIGO M. M.; ONDRASEK, GABRIJEL; BATISTA, BRUNO L. L.; SEABRA, AMEDEA B. B.; OLIVEIRA, HALLEY C. C.. Soil Treatment with Nitric Oxide-Releasing Chitosan Nanoparticles Protects the Root System and Promotes the Growth of Soybean Plants under Copper Stress. PLANTS-BASEL, v. 11, n. 23, p. 24-pg., 2022-12-01. (18/08194-2, 20/03646-2, 22/00321-0)

SEABRA, AMEDEA B.; PIERETTI, JOANA C.; SANTANA, BIANCA DE MELO; HORUE, MANUEL; TORTELLA, GONZALO R.; CASTRO, GUILLERMO R.. Pharmacological applications of nitric oxide-releasing biomaterials in human skin. International Journal of Pharmaceutics, v. 630, p. 14-pg., 2023-01-05. (22/00321-0, 20/03646-2)

PIERETTI, JOANA CLAUDIO; FREIRE, BRUNA MOREIRA; ARMENTANO, GIOVANA MARCHINI; SANTANA, BIANCA DE MELO; BATISTA, BRUNO LEMOS; CARNEIRO-RAMOS, MARCELA SORELLI; SEABRA, AMEDEA BAROZZI. Chronic exposure to nitric oxide sensitizes prostate cancer cells and improved ZnO/CisPt NPs cytotoxicity and selectivity. International Journal of Pharmaceutics, v. 640, p. 8-pg., 2023-05-10. (22/00321-0, 20/03646-2, 20/08566-7, 22/00153-0)

VERA, JOELIS; HERRERA, WENCE; HERMOSILLA, EDWARD; SCHALCHLI, HEIDI; DIAZ, RAMIRO; FINCHEIRA, PAOLA; SEABRA, AMEDEA B.; QUIROZ, ANDRES; TORTELLA, GONZALO; RUBILAR, OLGA. Photodegradation of lignin biowaste catalyzed by biosynthesized zinc oxide nanoparticles using the leaf extract of Aristotelia chilensis. RESULTS IN ENGINEERING, v. 25, p. 14-pg., 2025-01-03. (22/00321-0, 22/13444-3)

LOURENCO, ISABELLA MARTINS; SEABRA, AMEDEA BAROZZI; VERA, MARCELO LIZAMA; HOFFMAN, NICOLAS; ARANEDA, OLGA RUBILAR; PARRA, LEONARDO BARDEHLE. Synthesis and application of zinc oxide nanoparticles in Pieris brassicae larvae as a possible pesticide effect. AIMS MOLECULAR SCIENCE, v. 11, n. 4, p. 16-pg., 2024-01-01. (22/00321-0)

PIERETTI, JOANA C.; PELEGRINO, MILENA T.; SILVEIRA, NEIDIQUELE M.; RODRIGUES, MAIARA G.; SEABRA, AMEDEA B.. State-of-the-Art and Perspectives for Nanomaterials Combined with Nitric Oxide Donors: From Biomedical to Agricultural Applications. ACS APPLIED NANO MATERIALS, v. 7, n. 16, p. 20-pg., 2023-10-20. (20/03646-2, 22/00321-0)

FINCHEIRA, PAOLA; ESPINOZA, JAVIER; LEVIO-RAIMAN, MARCELA; VERA, JOELIS; TORTELLA, GONZALO; BRITO, ADRIANNE MARLISE MENDES; SEABRA, AMEDEA B.; DIEZ, MARIA CRISTINA; QUIROZ, ANDRES; RUBILAR, OLGA. Formulation of essential oils-loaded solid lipid nanoparticles-based chitosan/PVA hydrogels to control the growth of Botrytis cinerea and Penicillium expansum. International Journal of Biological Macromolecules, v. 270, p. 13-pg., 2024-05-17. (22/00321-0)

TORTELLA, GONZALO; RUBILAR, OLGA; FINCHEIRA, PAOLA; PARADA, JAVIERA; DE OLIVEIRA, HALLEY CAIXETA; BENAVIDES-MENDOZA, ADALBERTO; LEIVA, SEBASTIAN; FERNANDEZ-BALDO, MARTIN; SEABRA, AMEDEA B.. Copper nanoparticles as a potential emerging pollutant: Divergent effects in the agriculture, risk-benefit balance and integrated strategies for its use. EMERGING CONTAMINANTS, v. 10, n. 4, p. 15-pg., 2024-12-01. (22/00321-0)

FERNANDEZ-TRIANA, I.; RUBILAR, O.; PARADA, J.; FINCHEIRA, P.; BENAVIDES-MENDOZA, A.; DURAN, P.; FERNANDEZ-BALDO, MARTIN; SEABRA, A. B.; TORTELLA, G. R.. Metal nanoparticles and pesticides under global climate change: Assessing the combined effects of multiple abiotic stressors on soil microbial ecosystems. Science of The Total Environment, v. 942, p. 17-pg., 2024-06-11. (22/00321-0)

GOMEZ, GERMAN E.; HAMER, MARIANA; REGIART, MATIAS D.; TORTELLA, GONZALO R.; SEABRA, AMEDEA B.; SOLER ILLIA, GALO J. A. A.; FERNANDEZ-BALDO, MARTIN A.. Advances in Nanomaterials and Composites Based on Mesoporous Materials as Antimicrobial Agents: Relevant Applications in Human Health. ANTIBIOTICS-BASEL, v. 13, n. 2, p. 26-pg., 2024-02-01. (22/00321-0)

DOS REIS, ROBERTA ALBINO; SARKAR, ISHANI; RODRIGUES, MAIARA GONCALVES; MATSON, JOHN B.; SEABRA, AMEDEA BAROZZI; KASHFI, KHOSROW. NO- and H2S-releasing nanomaterials: A crosstalk signaling pathway in cancer. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 151, p. 14-pg., 2024-09-05. (22/00321-0, 22/14645-2, 23/16363-7)

FINCHEIRA, PAOLA; HOFFMANN, NICOLAS; TORTELLA, GONZALO; RUIZ, ANTONIETA; CORNEJO, PABLO; DIEZ, MARIA CRISTINA; SEABRA, AMEDEA B.; BENAVIDES-MENDOZA, ADALBERTO; RUBILAR, OLGA. Eco-Efficient Systems Based on Nanocarriers for the Controlled Release of Fertilizers and Pesticides: Toward Smart Agriculture. NANOMATERIALS, v. 13, n. 13, p. 22-pg., 2023-07-01. (22/00321-0)

OLIVEIRA, HALLEY CAIXETA; SEABRA, AMEDEA BAROZZI; KONDAK, SELAHATTIN; ADEDOKUN, OLUWATOSIN PEACE; KOLBERT, ZSUZSANNA. Multilevel approach to plant-nanomaterial relationships: from cells to living ecosystems. Journal of Experimental Botany, v. 74, n. 12, p. 19-pg., 2023-03-22. (22/00321-0, 17/21004-5)

CABRAL, FERNANDA V.; SANTANA, BIANCA DE MELO; LANGE, CAMILA N.; BATISTA, BRUNO L.; SEABRA, AMEDEA B.; RIBEIRO, MARTHA S.. Pluronic F-127 Hydrogels Containing Copper Oxide Nanoparticles and a Nitric Oxide Donor to Treat Skin Cancer. PHARMACEUTICS, v. 15, n. 7, p. 19-pg., 2023-07-01. (22/00321-0, 20/08566-7)

TORTELLA, GONZALO; RUBILAR, OLGA; PIERETTI, JOANA C.; FINCHEIRA, PAOLA; DE MELO SANTANA, BIANCA; FERNANDEZ-BALDO, MARTIN A.; BENAVIDES-MENDOZA, ADALBERTO; SEABRA, AMEDEA B.. Nanoparticles as a Promising Strategy to Mitigate Biotic Stress in Agriculture. ANTIBIOTICS-BASEL, v. 12, n. 2, p. 20-pg., 2023-02-01. (22/00321-0, 20/08566-7, 20/03646-2)

DA VEIGA, JULIA C.; SILVEIRA, NEIDIQUELE M.; SEABRA, AMEDEA B.; PIERETTI, JOANA C.; BOZA, YOLANDA; JACOMINO, ANGELO P.; CESAR FILHO, JULIO Z.; CAMPAGNOLI, VINICIUS P.; CIA, PATRICIA; BRON, ILANA U.. Spraying with encapsulated nitric oxide donor reduces weight loss and oxidative damage in papaya fruit. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 150, p. 10-pg., 2024-07-30. (23/13662-3, 20/03646-2, 22/00321-0)

RONDAN, WILFREDO; DOS REIS, ROBERTA ALBINO; ACUNA, JOSE JAVIER SAEZ; SEABRA, AMEDEA BAROZZI; CHAMPI, ANA. Influence of multilayers Bernal and Rhombohedral graphene obtained by green chemistry on the acceleration in the germination process of tomato seeds. DIAMOND AND RELATED MATERIALS, v. 145, p. 9-pg., 2024-04-18. (22/11894-1, 22/00321-0)

FREIRE, BRUNA MOREIRA; LANGE, CAMILA NEVES; CAVALCANTI, YASMIN TAVARES; MONTEIRO, LUCILENA REBELO; PIERETTI, JOANA CLAUDIO; SEABRA, AMEDEA BAROZZI; BATISTA, BRUNO LEMOS. The dual effect of Selenium nanoparticles in rice seedlings: From increasing antioxidant activity to inducing oxidative stress. PLANT STRESS, v. 11, p. 8-pg., 2024-01-30. (14/05151-0, 22/00321-0, 16/10060-9, 20/00284-2, 22/00208-0, 20/03646-2, 22/04254-6)

SANTANA, BIANCA DE MELO; ARMENTANO, GIOVANA MARCHINI; FERREIRA, DAYANA AGNES SANTOS; DE FREITAS, CAMILA SIMOES; CARNEIRO-RAMOS, MARCELA SORELLI; SEABRA, AMEDEA BAROZZI; CHRISTODOULIDES, MYRON. In Vitro Bactericidal Activity of Biogenic Copper Oxide Nanoparticles for Neisseria gonorrhoeae with Enhanced Compatibility for Human Cells. ACS APPLIED MATERIALS & INTERFACES, v. 16, n. 17, p. 10-pg., 2024-04-18. (21/13821-9, 22/00153-0, 20/08566-7, 22/00321-0)

FREIRE, BRUNA MOREIRA; LANGE, CAMILA NEVES; CAVALCANTI, YASMIN TAVARES; SEABRA, AMEDEA BAROZZI; BATISTA, BRUNO LEMOS. Ionomic Profile of Rice Seedlings after Foliar Application of Selenium Nanoparticles. TOXICS, v. 12, n. 7, p. 18-pg., 2024-07-01. (14/05151-0, 22/00321-0, 16/10060-9, 20/00284-2, 22/04254-6)

GOMES, DIEGO G.; SANADA, KARINA; PIERETTI, JOANA C.; SHIGUEOKA, LUCIANA H.; SERA, GUSTAVO H.; SEABRA, AMEDEA B.; OLIVEIRA, HALLEY C.. Nanoencapsulation Boosts the Copper-Induced Defense Responses of a Susceptible Coffea arabica Cultivar against Hemileia vastatrix. ANTIBIOTICS-BASEL, v. 12, n. 2, p. 22-pg., 2023-02-01. (22/00321-0, 20/03646-2)

SANTANA, BIANCA DE MELO; PIERETTI, JOANA CLAUDIO; GOMES, RAFAEL NUNES; CERCHIARO, GISELLE; SEABRA, AMEDEA BAROZZI. Cytotoxicity towards Breast Cancer Cells of Pluronic F-127/Hyaluronic Acid Hydrogel Containing Nitric Oxide Donor and Silica Nanoparticles Loaded with Cisplatin. PHARMACEUTICS, v. 14, n. 12, p. 16-pg., 2022-12-01. (20/03646-2, 20/08566-7, 22/00321-0)