Advanced search
Start date
Betweenand

Testing emotional vulnerability to threat in adults using a virtual reality paradigm of fear associated with autonomic variables

Grant number:21/14073-6
Support Opportunities:Regular Research Grants
Start date: June 01, 2022
End date: May 31, 2024
Field of knowledge:Health Sciences - Medicine - Psychiatry
Principal Investigator:Norberto Cysne Coimbra
Grantee:Norberto Cysne Coimbra
Host Institution:Instituto de Neurociências e Comportamento (INEC). Ribeirão Preto , SP, Brazil
City of the host institution:Ribeirão Preto
Associated researchers:Manoel Jorge Nobre Do Espirito Santo ; Norberto Cysne Coimbra ; Rita de Cassia Camargo Brandão ; Ruth Estevão
Associated scholarship(s):22/07916-0 - Development of virtual reality paradigms as models for different types of anxiety, BP.TT

Abstract

In view of the emergence of pandemics that devastate public health in Brazil and in the world, generating devastating effects on the population and, above all, leaving sequelae in the mental health of individuals with own experience of contagion or had close people who were affected by these diseases it is imperative that we undertake actions aimed at promoting strategies that improve people's emotional conditions to deal with threats and danger. Therefore, from the perspective of a more visible action now, as in the post-pandemic, it is necessary to install care services in the context of mental health in view of the dystopian manifestations that arise in individuals living in social emergency due to mental changes determined by the uncertainty of the conflict between preserving oneself or going out in search of the family's sustenance and survival. The current situation requires actions aimed at establishing tests, strategies and mechanisms to i) detect the level of mental health impairment determined by the new social modus faciendi. This project presents a model that associates the behavioral effects determined by the distance and intensity of aversive events (in this case, moderate and high-intensity white noise) with changes in heart rates, respiratory rates and blood oxygen saturation levels during a virtual paradigm prey/predator dynamic, developed here at INeC. Throughout the project, we will add blood pressure, skin electrical conductance and capnography records to the app. In this context, it is intended to assess the emotional condition of individuals living under conditions of social stress in current times. In addition, as socioeconomic and health conditions deteriorated, with regard to the social determinants of the pandemic, it is certain that a highly complex scenario was created with important consequences in the recruitment of adaptive processes that modulate the neural defense networks activated by the most diverse sources of emotional stress underlying the manifestations of different types of anxiety. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
More itemsLess items
Articles published in other media outlets ( ):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (7)
(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)
LAZARINI-LOPES, WILLIAN; SILVA-CARDOSO, GLEICE KELLI; CORTES DE OLIVEIRA, JOSE ANTONIO; CORREA PASSOS, LUIZ AUGUSTO; SALGADO, ANDREIA RUIS; RODRIGUES DEMOLIN, DANIELE MASSELLI; ANDRADE LEITE-PANISSI, CHRISTIE RAMOS; GARCIA-CAIRASCO, NORBERTO; COIMBRA, NORBERTO CYSNE. Inherited pain hypersensitivity and increased anxiety-like behaviors are associated with genetic epilepsy in Wistar Audiogenic Rats: Short- and long-term effects of acute and chronic seizures on nociception and anxiety. Epilepsy & Behavior, v. 141, p. 13-pg., . (21/14198-3, 21/13622-6, 20/15050-7, 21/14073-6, 19/05957-8, 18/06877-5)
OLIVEIRA, GABRIELA V. M.; SUZUKI, GABRIELA M. F.; SORIANO, RAFAEL F.; ALVES, LAIS V. DE CARVALHO; DE CARVALHO, MILLENA LANA C.; HERNANDES, PALOMA M.; WOTJAK, CARSTEN T.; COIMBRA, NORBERTO C.; ALMADA, RAFAEL C.. Differential modulation of contextual fear conditioning by orexin receptors in the dorsal hippocampus. Behavioural Brain Research, v. 501, p. 12-pg., . (23/00888-3, 18/03898-1, 19/01713-7, 20/15050-7, 21/06557-3, 21/14073-6, 24/01368-6)
FALCONI-SOBRINHO, LUIZ LUCIANO; DOS ANJOS-GARCIA, TAYLLON; REBELO, MACARIO AROSTI; HERNANDES, PALOMA MOLINA; ALMADA, RAFAEL CARVALHO; TANUS-SANTOS, JOSE EDUARDO; COIMBRA, NORBERTO CYSNE. The anterior cingulate cortex and its interface with the dorsal periaqueductal grey regulating nitric oxide-mediated panic-like behaviour and defensive antinociception. Neuropharmacology, v. 245, p. 17-pg., . (17/11855-8, 19/05255-3, 17/22647-7, 12/03798-0, 20/15050-7, 21/14073-6, 12/22681-7, 18/03898-1, 19/01713-7, 13/10984-8, 07/01174-1)
MEDEIROS, PRISCILA; MEDEIROS, ANA CAROLINA; DE FREITAS, RENATO LEONARDO; PIGATTO, GLAUCE REGINA; DE CAMPOS, ALLINE CRISTINA; KANASHIRO, ALEXANDRE; COIMBRA, NORBERTO CYSNE. Enriched environment prevents hypernociception and depression-like behavior in a psychiatric disorder and neuropathic pain comorbidity experimental condition. Physiology & Behavior, v. 291, p. 9-pg., . (14/11869-0, 13/12916-0, 17/13560-5, 11/20343-4, 21/14073-6)
FALCONI-SOBRINHO, LUIZ LUCIANO; FONSECA-RODRIGUES, DIANA; SILVA, ANA LAURA; DA SILVA, JOSIE RESENDE TORRES; COIMBRA, NORBERTO CYSNE; PINTO-RIBEIRO, FILIPA. Activation of NMDA Receptors in the Anterior Cingulate Cortex Enhances Anxiety-Induced Behaviour and Antinociception, and Contributes to the Modulation of Pain-Facilitatory Descending Pathways. EUROPEAN JOURNAL OF PAIN, v. 29, n. 6, p. 14-pg., . (21/13219-7, 17/11855-8, 07/01174-1, 12/03798-0, 20/15050-7, 19/05255-3, 21/14073-6)
KANASHIRO, ALEXANDRE; MEDEIROS, PRISCILA; MEDEIROS, ANA CAROLINA; FERREIRA, FREDERICO ROGERIO; CAMPOS, ALLINE CRISTINA DE; BARICHELLO, TATIANA; COIMBRA, NORBERTO CYSNE. Environmental enrichment prevents depression-like behaviours induced by immune system activation in male mice. Neuroscience Letters, v. 870, p. 8-pg., . (11/20343-4, 13/08216-2, 21/14073-6, 17/13560-5)
OLIVEIRA, GABRIELA V. M.; HERNANDES, PALOMA M.; SANTOS, FABIO H. DOS; SOARES, VICTOR P. M. N.; FALCONI-SOBRINHO, LUIZ LUCIANO; COIMBRA, NORBERTO C.; WOTJAK, CARSTEN T.; ALMADA, RAFAEL CARVALHO. Orexin mechanisms in the prelimbic cortex modulate the expression of contextual conditioned fear. Psychopharmacology, v. N/A, p. 12-pg., . (21/06557-3, 20/02724-0, 19/05255-3, 20/15050-7, 21/14073-6, 19/15757-6, 18/03898-1, 19/01713-7, 13/10984-8)