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Development of electrochemical sensors modified with hollow carbon nanospheres doped with sulfur and nitrogen for the quantification of drugs in supply water samples


Monitoring emerging pollutants in water and in the environment is crucial for human health as they can produce serious damage in human health. During this pandemic of the new coronavirus (COVID-19) and, as a consequence, the severe acute respiratory syndrome 2 (SARS-CoV-2), the consumption, and consequent elimination, of several specific drugs for the treatment of this viral infection, as well as its psychological effects inherent in human beings, constitutes a new threat to the environment and to the water supply. Thus, the monitoring and quantification of these new pollutants in water supplies are desirable, due to the lack of specific legislation for the presence of these pollutants in food. Thus, the present project aims to develop a set of electrochemical sensors for the monitoring of drugs of three important classes (antibiotics - azithromycin, amoxicillin, and levofloxacin - antidepressants - paroxetine, trazodone, and chlorpromazine - and corticoids - methylprednisolone, dextamethasone and hydrocortisone), consumed during the pandemic, in samples of supply water. The fabrication of the device will be carried out from the screen-printing process widely used to obtain miniaturized devices in a large-scale production. To improve the electrochemical performance of the device, it is intended to modify the electrode surface with carbon nanospheres doped with sulfur and nitrogen. (AU)

Articles published in Pesquisa para Inovação FAPESP about research grant:
Biodegradable sensor monitors levels of pesticides via direct contact with surface of fruit and vegetables 
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Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE CAMPOS, ANDERSON M.; SILVA, ROBSON R.; CALEGARO, MARCELO L.; RAYMUNDO-PEREIRA, PAULO A.. Design and Fabrication of Flexible Copper Sensor Decorated with Bismuth Micro/Nanodentrites to Detect Lead and Cadmium in Noninvasive Samples of Sweat. CHEMOSENSORS, v. 10, n. 11, p. 12-pg., . (22/02164-0, 16/06612-6, 16/01919-6)
GOMES, NATHALIA O.; PASCHOALIN, RAFAELLA T.; BILATTO, STANLEY; SORIGOTTI, AMANDA R.; FARINAS, CRISTIANE S.; MATTOSO, LUIZ HENRIQUE C.; MACHADO, SERGIO A. S.; OLIVEIRA JR, OSVALDO N.; RAYMUNDO-PEREIRA, PAULO A.. Flexible, Bifunctional Sensing Platform Made with Biodegradable Mats for Detecting Glucose in Urine. ACS SUSTAINABLE CHEMISTRY & ENGINEERING, v. 11, n. 6, p. 10-pg., . (19/01777-5, 20/09587-8, 16/10636-8, 17/18725-2, 18/22214-6, 13/07296-2, 18/10899-4, 22/02164-0, 16/01919-6)
RAYMUNDO-PEREIRA, PAULO A. A.. Biosensors for Monitoring of Biologically Relevant Molecules. BIOSENSORS-BASEL, v. 13, n. 7, p. 2-pg., . (22/02164-0, 23/00850-6, 16/01919-6)
GOMES, NATHALIA O.; TEIXEIRA, SAMIRIS COCCO; CALEGARO, MARCELO L.; MACHADO, SERGIO A. S.; FERREIRA SOARES, NILDA DE FATIMA; DE OLIVEIRA, TAILA VELOSO; RAYMUNDO-PEREIRA, PAULO A.. Flexible and sustainable printed sensor strips for on-site, fast decentralized self-testing of urinary biomarkers integrated with a portable wireless analyzer. CHEMICAL ENGINEERING JOURNAL, v. 472, p. 10-pg., . (23/07686-7, 19/01777-5, 22/02164-0, 23/00850-6, 16/01919-6, 20/09587-8)
CATUNDA, LUCAS GOMES DA SILVA; DO PRADO, THIAGO MARTIMIANO; DE OLIVEIRA, TASSIA REGINA; DOS SANTOS, DANIEL JUNIOR ALMEIDA; GOMES, NATHALIA OEZAU; CORREA, DANIEL SOUZA; FARIA, RONALDO CENSI; MACHADO, SERGIO ANTONIO SPINOLA. SARS-CoV-2 detection enabled by a portable and label-free photoelectrochemical genosensor using graphitic carbon nitride and gold nanoparticles. Electrochimica Acta, v. 451, p. 10-pg., . (22/02164-0, 20/04635-4, 18/22214-6, 20/09587-8, 20/07539-6)
IBANEZ-REDIN, GISELA; CAGNANI, GIOVANA ROSSO; GOMES, NATHALIA O.; RAYMUNDO-PEREIRA, PAULO A.; MACHADO, SERGIO A. S.; GUTIERREZ, MARCO ANTONIO; KRIEGER, JOSE EDUARDO; OLIVEIRA, OSVALDO N.. Wearable potentiometric biosensor for analysis of urea in sweat. BIOSENSORS & BIOELECTRONICS, v. 223, p. 8-pg., . (14/50889-7, 18/22214-6, 22/02164-0, 20/09587-8, 16/01919-6, 20/14906-5)

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