Reactivity of polynuclear ruthenium compounds with potential biological application

• Grant number: 22/03478-8
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2022
• End date: October 31, 2024
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Sofia Nikolaou
• Grantee: Sofia Nikolaou
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated researchers: Claudia Turro

Abstract

In the context of the research carried out by my group, the LABiQSC2 (Laboratory of Biological Activity and Supramolecular Chemistry of Coordination Compounds, https://sites.usp.br/labiqsc2/), which focuses on investigation of the biological activity of ruthenium compounds as one of its main goals, this project aims to study the reactivity of some trinuclear complexes under conditions of biological interest or in order to obtain new complexes that are also potentially interesting for biological applications. Therefore, we will focus on water-soluble complexes with the general formula [Ru3O(CH3COO)6(L)3]CH3COO (L = H2O; 4-aminopyridine; imidazole; 1-(2-hydroxyethyl)imidazole; 1-(3-hydroxypropyl )imidazole; 1-(3-aminopropyl)imidazole; Imidazole-1-acetic acid), on the investigation of its acid-base chemistry and, specifically in the case of the complex [Ru3O(CH3COO)6(H2O)3]CH3COO , its reactivity with the amino acid histidine will be studied. The counterpoint to reactivity with amino acids will be done from the same type of study, but involving the labile complexes [Ru2O(CH3COO)2(py)4(L)2](PF6)2 (L = N-heterocyclic ligand). The reactivity of the [Ru3O(CH3COO)6(H2O)3]CH3COO complex will be further explored in order to establish a systematic synthetic method for binuclear complexes with the general formula [Ru2(¼-O){·2(N,N)-phen}2 {¼-·1(C),·2(N,N)-phen}2](PF6)2 through orthometalation reactions of the phenanthroline series 1,10-phenanthroline, 5-chloro-1,10-phenanthroline, 5- methyl-1,10-phenanthroline and 1,10-phenanthroline-5,6-dione. We will also study the release of biological actives molecules CO and NO from redox stimulation through the reactions of the complexes [Ru3O(CH3COO)6(pyridine)2(L)] (L = CO or NO) with the redox agents H2O2 and ascorbic acid. In all cases, the complexes will be synthesized and purified and their characterization will be carried out by spectroscopic (NMR, UV-visible, infra-red) and electrochemical (cyclic voltammetry) techniques, complemented by measurements of elemental analysis and mass spectrometry. EPR measurements at liquid helium temperature (< 10 K) and excited state dynamics will be performed at The Ohio State University, in collaboration with the Turro Research Group. The study of reactivity and identification of the species involved in the reactions will be carried out with monitoring by UV-visible spectroscopy or by cyclic voltammetry and by spectroelectrochemical measurements. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CACITA, NATACHA; SILVA, AMANDA BATISTA; DOS SANTOS, NICOLLE AZEVEDO PORTELA; RAMOS, LOYANNE CARLA BARBOSA; DEL LAMA, MARIA PERPETUA FREIRE DE MORAES; NAAL, ROSE MARY ZUMSTEIN GEORGETTO; NIKOLAOU, SOFIA. Interactions with HSA, anticancer and antiallergic activity of binuclear mu-oxo bridged ruthenium acetate compounds. CHEMISTRYSELECT, v. 8, n. 13, p. 10-pg., 2023-04-05. (22/03478-8, 21/02802-3, 18/18060-3, 19/14170-1)

BATISTA, ANA PAULA DE LIMA; PAVAN, JAMILE ROCHA; RIBEIRO, MARCOS ANTONIO; NIKOLAOU, SOFIA. Unveiling the electronic and molecular structure of a trinuclear ruthenium cluster containing one nitrosyl ligand. Journal of Molecular Structure, v. 1308, p. 10-pg., 2024-03-29. (22/03478-8, 18/18060-3, 22/12043-5, 21/00675-4)

PINHEIRO, BRUNO F. A.; FERNANDES, NATHAN C.; CHAVES, OTAVIO A.; ELLENA, JAVIER A.; DE QUEIROZ, MARIANA S.; TEDESCO, ANTONIO C.; DE ARAUJO-NETO, JOAO H.; NIKOLAOU, SOFIA. Water-Soluble μ-oxo triruthenium Compound of Biological Interest: H-Bonds Network and Interaction with HSA. European Journal of Inorganic Chemistry, v. 27, n. 13, p. 11-pg., 2024-04-10. (21/04876-4, 19/04173-3, 22/03478-8, 21/14050-6, 23/07614-6)

DO NASCIMENTO, LUIS GUILHERME A.; BARBETTA, MAIKE F. S.; CHAVES, OTAVIO A.; DE OLIVEIRA, ANDERSON R. M.; NIKOLAOU, SOFIA. Interaction of a Triruthenium ortho-Metallated Phenazine with Cytochrome P450 Enzymes. Journal of the Brazilian Chemical Society, v. 35, n. 10, p. 9-pg., 2024-01-01. (22/03478-8, 21/10098-4)

IGLESIAS, BERNARDO ALMEIDA; PERANZONI, NICKOLAS PIPPI; FARIA, SOPHIA IWERSEN; TRENTIN, LUANA BELO; SCHUCH, ANDRE PASSAGLIA; CHAVES, OTAVIO AUGUSTO; BERTOLONI, RENAN RIBEIRO; NIKOLAOU, SOFIA; DE OLIVEIRA, KLEBER THIAGO. DNA-Interactive and Damage Study with meso-Tetra(2-thienyl)porphyrins Coordinated with Polypyridyl Pd(II) and Pt(II) Complexes. Molecules, v. 28, n. 13, p. 16-pg., 2023-07-01. (22/03478-8, 20/06874-6, 13/07276-1)