Development of a graphene/B-cyclodextrin-based sensor for the electrochemical detection of ivermectin in effluents

• Grant number: 22/03762-8
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2022
• End date: November 30, 2024
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Ivana Cesarino
• Grantee: Ivana Cesarino
• Host Institution: Faculdade de Ciências Agronômicas (FCA). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Associated researchers: Rafael Plana Simões

Abstract

This project aims at the development, characterization and application of a new electrochemical sensor for the detection of ivermectin (IVM) in effluents. The COVID-19 pandemic has caused millions of deaths around the world. As a way to control this disease, numerous drugs were tested, however, even without proper scientific evidence, some of them were widely consumed by the Brazilian population. The exacerbated consumption of these medicines exposes the fauna, flora and population of the country to risks of contamination, and traditional methods of water treatment are not able to treat them efficiently. To enhance decontamination, monitoring strategies that present high sensitivity, reproducibility, low cost and the possibility of in situ analysis are needed. Therefore, this project aims to develop an electrochemical platform based on reduced graphene oxide (rGO) and on the macrocyclic host molecule B-cyclodextrin (B-CD) for the analysis of IVM. The detection method is based on the guest-host characteristics of B-CD and on the competitive interaction between the target analyte and the methylene blue (MB) redox probe, resulting in a new methodology for the indirect determination of IVM. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MELARE, ALINE GIULI; BARRETO, FRANCISCO CONTINI; SILVA, MARTIN KASSIO LEME; SIMOES, RAFAEL PLANA; CESARINO, IVANA. Determination of Fluoxetine in Weight Loss Herbal Medicine Using an Electrochemical Sensor Based on rGO-CuNPs. Molecules, v. 28, n. 17, p. 15-pg., 2023-09-01. (22/03762-8)

BARRETO, FRANCISCO CONTINI; DA SILVA, MARTIN KASSIO LEME; CESARINO, IVANA. Copper Nanoparticles and Reduced Graphene Oxide as an Electrode Modifier for the Development of an Electrochemical Sensing Platform for Chloroquine Phosphate Determination. NANOMATERIALS, v. 13, n. 9, p. 11-pg., 2023-04-22. (22/03334-6, 22/03762-8)