Multi-omic analysis of metabolism and microbiota of healthy and sick dogs and cats

• Grant number: 22/06499-6
• Support Opportunities: Generation Project Research Grant
• Start date: May 01, 2023
• End date: April 30, 2028
• Field of knowledge: Agronomical Sciences - Animal Husbandry - Animal Nutrition and Feeding
• Principal Investigator: Thiago Henrique Annibale Vendramini
• Grantee: Thiago Henrique Annibale Vendramini
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Cecilia Luisa Villaverde Haro ; Christina Ramires Ferreira ; Júlio Cesar de Carvalho Balieiro ; Karina Pfrimer ; Luiz Alberto Colnago ; Márcio Antonio Brunetto ; Maria Lucia Zaidan Dagli
• Associated scholarship(s): 24/19186-1 - Multiomic analysis of metabolism in healthy and diseased dogs and cats, BP.DR; 24/07814-8 - Analysis of Body Composition in Healthy Dogs and Cats and Those with Oral Melanoma, BP.IC; 24/04298-9 - Body composition analysis of healthy dogs and cats and of those with chronic kidney disease, BP.IC; + associated scholarships 24/04508-3 - BODY COMPOSITION ASSESSMENT OF HEALTHY AND OBESE DOGS AND CATS, BP.IC; 23/16785-9 - Multi-Omic Analysis of Metabolism and Microbiome in Healthy Dogs and Cats and Those with Oral Melanoma, BP.MS; 23/07726-9 - MULTI-OHMIC ANALYSIS OF THE METABOLISM AND MICROBIOME IN HEALTHY AND OBESE DOGS AND CATS, BP.MS; 23/07727-5 - MULTI-OHMIC ANALYSIS OF THE METABOLISM AND MICROBIOME OF HEALTHY DOGS AND CATS AND OF THOSE WITH CHRONIC KIDNEY DISEASE, BP.MS; 23/07307-6 - Multi-omic analysis of metabolism and microbiota of healthy and sick dogs and cats, BP.GR - associated scholarships

Abstract

The larger terminology concept defines multi-omics as the sum of information obtained by the "omics" sciences, at the same time the microbiome has been associated with health status and the risk of developing diseases. These points together suggest that the genetic richness of diverse microbial symbionts may play an extremely important role. In particular, the variation of metabolism and the microbiome can jointly encode essential results for health and fitness, that is, recent years of scientific research have demonstrated the importance of microorganisms in the health and disease of organisms, in addition, the recent The development of molecular techniques and the expansion of knowledge that provide metabolic information is also moving at an accelerated pace, thus allowing the sum of this information and the joint evaluation of the results obtained. In this way, based on the immense advance on the frontier of international knowledge, the objective of the present proposal is to explore, through this proposal, in a pioneering way, the multi-omic analysis of the metabolism and microbiome of healthy and sick dogs and cats, characterizing the fecal microbiota. , identifying genetic and metabolic variations through the "omics" sciences (lipidomics and metabolomics) and drawing multiple parallels between these two factors and other information such as body composition. Therefore, the project aims to explore three main themes, which encompass the main diseases that affect companion animals (obesity, chronic kidney disease and cancer), working with both species (dogs and cats) and therefore fragmenting the project into 6 sub-themes. for acting. The objective is still, possibly due to the originality and boldness of the proposals, to use the potential of animals as a model for human medicine and even allow the identification of new biomarkers of intra-species and inter-species disease. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

AMARAL, ANDRESSA R.; FINARDI, GABRIELA L. F.; MARCHI, PEDRO H.; DE OLIVEIRA, NATALIA M. C.; PRINCIPE, LEONARDO A.; TEIXEIRA, NATACHA; PAPPALARDO, MARIA C. F.; LIMA, LAIS O. C.; CIRILLO, JULIANA V.; BALIEIRO, JULIO CESAR DE C.; et al. Connection between nutrition and oncology in dogs and cats: perspectives, evidence, and implications-a comprehensive review. FRONTIERS IN VETERINARY SCIENCE, v. 11, p. 19-pg., 2025-02-18. (23/07727-5, 23/07307-6, 23/16785-9, 22/06499-6, 23/07726-9, 23/09486-5)

CESAR, CINTHIA GONCALVES LENZ; MARCHI, PEDRO HENRIQUE; AMARAL, ANDRESSA RODRIGUES; DE ANDRADE PRINCIPE, LEONARDO; DO CARMO, ADRIELLY APARECIDA; ZAFALON, RAFAEL VESSECCHI AMORIM; MIYAMOTO, NELSON NOBUHIRO; GARCIA, NURY AYMEE COLLONA RODRIGUEZ; DE CARVALHO BALIEIRO, JULIO CESAR; VENDRAMINI, THIAGO HENRIQUE ANNIBALE. An Assessment of the Impact of Insect Meal in Dry Food on a Dog with a Food Allergy: A Case Report. ANIMALS, v. 14, n. 19, p. 8-pg., 2024-10-01. (23/09486-5, 23/07307-6, 22/06499-6)

MARCHI, PEDRO HENRIQUE; MIRANDA, MARIANA DOS SANTOS; PRINCIPE, LEONARDO DE ANDRADE; ZAFALON, RAFAEL VESSECCHI AMORIM; AMARAL, ANDRESSA RODRIGUES; CESAR, CINTHIA GONCALVES LENZ; BALIEIRO, JULIO CESAR DE CARVALHO; VENDRAMINI, THIAGO HENRIQUE ANNIBALE. Allergic Reaction to Beta-Glucans in an Obese Dog: A Case Report of Confirmed and Suspected Sources. JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION, v. N/A, p. 6-pg., 2025-03-13. (23/07307-6, 23/09486-5, 22/06499-6)