Evaluation of intestinal permeability, dysbiosis and expression of microRNAs in patients with Inflammatory Bowel Disease (IBD) and association with Non-Alcoholic Fatty Liver Disease (NAFLD)

• Grant number: 22/15527-3
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2023
• End date: August 31, 2026
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Ligia Yukie Sassaki
• Grantee: Ligia Yukie Sassaki
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• City of the host institution: Botucatu
• Associated researchers: Ana Elisa Valencise Quaglio ; Andrey dos Santos ; Daniéla Oliveira Magro ; Débora Barbosa Vendramini Costa ; Luiz Claudio Di Stasi ; Mario Jose Abdalla Saad
• Associated scholarship(s): 24/18274-4 - Training and development of microRNA analysis in samples from patients with Inflammatory Bowel Disease (IBD) associated or not with Non-Alcoholic Fatty Liver Disease (NAFLD), BP.TT

Abstract

The intestinal microbiota is known to provide several benefits to its host, due to the symbiotic interaction established between them. An imbalance between beneficial and pathogenic bacteria in the intestine, known as dysbiosis, can result in the development of diseases such as diabetes, obesity, liver diseases, such as Non-Alcoholic Fatty Liver Disease (NAFLD), and the Inflammatory Bowel Disease (IBD), considered one of the main diseases related to dysbiosis, which includes Crohn's Disease and Ulcerative Colitis. Several studies show that around 33% of IBD patients develop NAFLD, due to the pathophysiological mechanisms present in both diseases. NAFLD is a chronic disease, characterized by excessive hepatic fat deposits, and just like in IBD, studies indicate that changes in the intestinal permeability and intestinal microbiota may have an important role in the development of this disease. In addition to dysbiosis, microRNAs (miRNAs) have also recently been associated with the evolutionary etiology of IBD and NAFLD, as well as in the participation of modulation of the intestinal microbiota and induction of dysbiosis, while the microbiota can regulate the expression of miRNAs and thus alter intestinal homeostasis. Based on this, the present study aims to analyze the profile of the microRNAs, intestinal permeability and the presence of dysbiosis of patients with IBD and compare findings between groups IBD with NAFLD and IBD without NAFLD. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LOPES, MARINA AMORIM; OLIVEIRA, ELLEN CRISTINA SOUZA; QUAGLIO, ANA ELISA VALENCISE; SANTOS, ANDREY; IMBRIZI, MARCELLO; MENDES, LETICIA EVELYN ROCHA; BERALDO, RODRIGO FEDATTO; BAIMA, JULIO PINHEIRO; SPILLER, AMANDA LUISA; MAGRO, DANIELA OLIVEIRA; et al. From gut to liver: Exploring the relationship between inflammatory bowel disease and metabolic dysfunction-associated steatotic liver disease. WORLD JOURNAL OF HEPATOLOGY, v. 17, n. 9, p. 13-pg., 2025-09-27. (22/15527-3)