Acute cardiovascular effects of arm cranking exercise pin patients with Peripheral Arterial Disease

• Grant number: 23/00630-6
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2023
• End date: October 31, 2025
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Raphael Mendes Ritti Dias
• Grantee: Raphael Mendes Ritti Dias
• Host Institution: Universidade Nove de Julho (UNINOVE). Campus Vergueiro. São Paulo , SP, Brazil
• Associated researchers: Gabriel Grizzo Cucato ; Hélcio Kanegusuku ; Marilia de Almeida Correia ; Nelson Wolosker

Abstract

Patients with peripheral arterial disease (PAD) are at high risk of fatal and non-fatal cardiovascular events. Therefore, strategies that assist in reducing cardiovascular risk in these patients are necessary. Studies have shown that arm-cranking exercise (ACE), a type of painless exercise, improves the functional capacity of patients with PAD. However, the local and systemic vascular responses to this type of exercise, as well as its mechanisms, are not yet well-established. OBJECTIVE: To analyze the acute local and systemic vascular responses to ACE in patients with PAD and compare them with the current exercise recommendation, walking exercise (WA). METHODS: The present study involves the execution of two studies. In the first study, patients with PAD and claudication symptoms will perform three experimental sessions in random order: walking exercise (WA), ACE, and control (SC). Before and after each experimental session, vascular function in the upper and lower limbs, blood pressure and heart rate will be assessed. During the sessions, blood pressure, heart rate, subjective perception of effort, and affective response will be measured. In the second study, the potential vascular mechanisms involved in the effect of ACE exercise on vascular function will be analyzed. To this end, a subsample of patients will undergo three experimental sessions: ACE, leg warm-up, and control. In these sessions, blood flow patterns (antegrade and retrograde shear stress, oscillation index) will be measured in the lower limbs during the intervention. (AU)