Acute and chronic cardiovascular responses to physical exercise in intermitent claudication patients

• Grant number: 09/17371-6
• Support Opportunities: Regular Research Grants
• Duration: March 01, 2010 - February 29, 2012
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Cláudia Lúcia de Moraes Forjaz
• Grantee: Cláudia Lúcia de Moraes Forjaz
• Host Institution: Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Physical exercise is recommended for patients with intermittent claudication (IC). However, its effects on cardiovascular function and health were not studied yet. The objective of this study will be to analyze acute and chronic effects of walking in patients with IC. Thirty patients with IC will be recruited from the Vascular Surgery Ambulatory of Hospital das Clínicas-FMUSP. Inclusion criteria is: age equal or greater than 50 years, level II of peripheral obstructive disease, capacity to walk for at least 2 min at 3.2 Km/h, and systolic and diastolic blood pressure (BP) levels lower than 160 and 105 mmHg, respectively. All subjects will underwent a maximal cardiopulmonary exercise test, and they will be randomly divided in two groups: walking training (WT) and control (CO). Training will consist of 15 sets of walking on a treadmill for 2 min at an intensity corresponding to the heart rate of claudication threshold, followed by 2 min of passive rest. At the beginning of the study and 12 weeks after training or control intervention, clinic and ambulatory blood pressures, cardiac output, heart rate, heart rate variability, muscle blood flow, vascular reactivity, resting and post-exercise ankle-brachial index, claudication distance, total walking distance, and peak VO2 will be measured. To evaluate the acute effects of walking, all of these variables will be also measured in the WT group before and after the fourth session of training, and this response will be compared to the one observed in a control session, in which variables were be measured before and after 60 min of seated rest. Data will be analyzed by 2-way ANOVA for repeated measures. Post-hoc comparisons will be performed with Newman-Keuls' test, and a P level P<0.05 will be accepted as significant. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CHEHUEN, MARCEL; CUCATO, GABRIEL G.; CARVALHO, CELSO RICARDO F.; RITTI-DIAS, RAPHAEL M.; WOLOSKER, NELSON; LEICHT, ANTHONY S.; FORJAZ, CLAUDIA LUCIA M.. Walking training at the heart rate of pain threshold improves cardiovascular function and autonomic regulation in intermittent claudication: A randomized controlled trial. JOURNAL OF SCIENCE AND MEDICINE IN SPORT, v. 20, n. 10, p. 886-892, OCT 2017. (09/17371-6, 12/16700-9)

CHEHUEN, MARCEL DA ROCHA; CUCATO, GABRIEL GRIZZO; SAES, GLAUCO FERNANDES; RIANI COSTA, LUIZ AUGUSTO; LEICHT, ANTHONY SCOTT; RITTI-DIAS, RAPHAEL MENDES; WOLOSKER, NELSON; DE MORAES FORJAZ, CLAUDIA LUCIA. Reproducibility of Anaerobic and Pain Thresholds in Male Patients With Intermittent Claudication. Journal of Cardiopulmonary Rehabilitation and Prevention, v. 36, n. 5, p. 358-367, SEP-OCT 2016. (09/17371-6)

FECCHIO, RAFAEL YOKOYAMA; CHEHUEN, MARCEL; PECANHA, TIAGO; CUCATO, GABRIEL GRIZZO; RIANI COSTA, LUIZ AUGUSTO; LEICHT, ANTHONY SCOTT; RITTI-DIAS, RAPHAEL MENDES; WOLOSKER, NELSON; DE MORAES FORJAZ, CLAUDIA LUCIA. Reproducibility of heart rate recovery in patients with intermittent claudication. CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING, v. 38, n. 4, p. 603-609, JUL 2018. (15/13800-0, 09/17371-6)