Cardiovascular and autonomic responses to maximal exercise in men and women with intermittent claudication

• Grant number: 17/12973-4
• Support Opportunities: Scholarships in Brazil - Master
• Start date: April 01, 2018
• End date: March 31, 2019
• Field of knowledge: Health Sciences - Physical Education
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Cláudia Lúcia de Moraes Forjaz
• Grantee: Roberto Sanches Miyasato
• Host Institution: Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Peripheral Artery Disease (PAD) is characterized by the presence of obstructions in the arteries of the lower limbs, which reduce blood supply to the muscles, causing pain during exercise (intermittent claudication - IC). Walking is recommended for the treatment of this disease, but its execution causes cardiovascular and metabolic responses different from those observed in healthy individuals. These responses have already been investigated in men with PAD and IC. However, although the prevalence of this disease is equal in men and women and its functional consequences are greater in women, the acute physiological responses to walking have not been investigated in women. Thus, the objective of this study is to evaluate and compare the functional, cardiovascular and autonomic responses to a maximal cardiopulmonaryexercise test in men and women with PAD and IC. For this, 40 individuals with PAD and IC (20 men and 20 women) will perform, in a random order, two experimental sessions: control (rest on the treadmill) and exercise (a maximal treadmill test). During exercise, functional capacity (initial claudication distance, total walking distance and peak oxygen consumption) and submaximal and maximal cardiovascular responses (heart rate-HR and BP) will be assessed. In addition, before and after the sessions, the following measures will be assessed: cardiovascular (BP, HR, cardiac output, peripheral vascular resistance, systolic volume and rate pressure product) and autonomic (HR and BP variabilities as well as baroreflex sensitivity) variables. Finally, after both sessions, an ambulatory BPmonitoring will be conducted for 24h. Data will be compared by the t-test and 2-way ANOVA, with P <0.05. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ROBERTO SANCHES MIYASATO; ALEX JESUS FELIX; ALUÍSIO ANDRADE-LIMA; NATAN DANIEL DA SILVA JÚNIOR; RAPHAEL MENDES RITTI-DIAS; NELSON WOLOSKER; VÉRONIQUE CORNELISSEN; KARLA FABIANA GOESSLER; CLAÚDIA LÚCIA DE MORAES FORJAZ. Physiological responses during walking in men and women with intermittent claudication. Einstein (São Paulo), v. 21, 2023-12-15. (17/12973-4)

MIYASATO, ROBERTO SANCHES; FELIX, ALEX JESUS; ANDRADE-LIMA, ALUISIO; DA SILVA, JR., NATAN DANIEL; RITTI-DIAS, RAPHAEL MENDES; WOLOSKER, NELSON; CORNELISSEN, VERONIQUE; GOESSLER, KARLA FABIANA; DE MORAES FORJAZ, CLAUDIA LUCIA. Cardiovascular Responses during and after Maximal Walking in Men and Women with Symptomatic Peripheral Artery Disease. ANNALS OF VASCULAR SURGERY, v. 71, p. 9-18, FEB 2021. (17/12973-4)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

MIYASATO, Roberto Sanches. Cardiovascular and autonomic responses to maximal exercise in men and women with intermittent claudication.. 2019. Master's Dissertation - Universidade de São Paulo (USP). Escola de Educação Física e Esportes (EEFE/BT) São Paulo.