Natural sanitizer against nosocomial infection agents by Machaerium and Byrsonima

• Grant number: 24/17324-8
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2026
• End date: June 30, 2029
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Miriam Sannomiya
• Grantee: Miriam Sannomiya
• Host Institution: Escola de Artes, Ciências e Humanidades (EACH). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Ana Paula Fortuna Perez ; Karina Alves de Toledo ; Kelly Ishida ; Ligia Carla Faccin Galhardi

Abstract

Hospital sanitation is responsible for ensuring that the environments in which vulnerable patients are located do not pose a risk to their health. Effective sanitation, however, is not easy to achieve. Around 50% of hospital surfaces were found to be contaminated, due to lapses in the effectiveness of the sanitizers currently used, which in addition to recontamination, can even induce microbial resistance. The infections generated by these pathogens, which are mostly opportunistic, are called "nosocomial infections" and are an important cause of death in worsening clinical conditions of immunocompromised patients, which can be fungi, bacteria and viruses. In this context, plant extracts from the Byrsonima and Machaerium genera and their isolated molecules can be important allies in the prevention of nosocomial infections, given their antimicrobial and antiviral potential already established in the literature. This project aims, therefore, to evaluate the fungicidal, bactericidal and virucidal activities and identify the molecules present in the extract(s), culminating in tests of the extracts, fractions and/or isolates in sanitizer formulations. (AU)