Bioenergetic, ionic transport and redox equilibrium in mitochondria

• Grant number: 06/60497-2
• Support Opportunities: Research Projects - Thematic Grants
• Start date: April 01, 2007
• End date: March 31, 2011
• Field of knowledge: Biological Sciences - Biochemistry - Metabolism and Bioenergetics
• Principal Investigator: Alicia Juliana Kowaltowski
• Grantee: Alicia Juliana Kowaltowski
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 07/53455-4 - Bioenergetic and redox effects of caloric restriction and systemic uncoupling, BP.DR

Abstract

Changes in mitochondrial energy metabolism, ion transport and redox balance are associated with a variety of physiological and pathological conditions including aging, obesity, heart attack and stroke.The central aim of this project is to analyze the role of alterations in mitochondrial ion transport, energy metabolism and/or redox state in these physiopathological conditions.We expect, with our studies, to offer the possibilities for the creation of interventions capable of controlling these unwelcome mitochondrial and cellular effects. (AU)