Influence of the salt deficient diet on atherosclerosis risk factors: measurements in the fasting and in the alimentary phases

• Grant number: 00/04249-3
• Support Opportunities: Research Projects - Thematic Grants
• Start date: November 01, 2000
• End date: July 31, 2006
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Eder Carlos Rocha Quintão
• Grantee: Eder Carlos Rocha Quintão
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Present work in moderately hypertensive subjects (n=40) aims at evaluating the influence of a low sodium chloride diet on the modifications of several risk factors for premature atherosclerosis. The rationale for this study stems on the knowledge that lowering blood pressure confers clear protection against the incidence of cerebro-vascular accidents but clear evidences of protection against coronary artery disease are missing possibly due to potential adverse effects of the salt restriction on plasma lipoproteins, coagulation factors, insulin resistance and vascular reactivity. Furthermore, since some of these factors may worsen during the alimentary phase, a period measurements will be carried out in the fasting state and after a standard fatty test meal according to a crossover designed protocol consisting of two-week periods on a normal salt (150mmol/d) as compared to a low salt diet (40mmol/d). (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NAKANDAKARE, EDNA R.; CHARF, ANA M.; SANTOS, FLAVIA C.; NUNES, VALERIA S.; ORTEGA, KATIA; LOTTENBERG, ANA M. P.; MION, JR., DECIO; NAKANO, TAKAMITSU; NAKAJIMA, KATSUYUKI; D'AMICO, ELBIO A.; et al. Dietary salt restriction increases plasma lipoprotein and inflammatory marker concentrations in hypertensive patients. ATHEROSCLEROSIS, v. 200, n. 2, p. 410-416, OCT 2008. (00/04249-3)