Chemistry, photochemistry and biological applications of ruthenium complexes with nitric oxide and related species. From solution to materials

• Grant number: 06/53266-4
• Support Opportunities: Research Projects - Thematic Grants
• Start date: May 01, 2008
• End date: October 31, 2012
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Elia Tfouni
• Grantee: Elia Tfouni
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Pesquisadores principais: Alzir Azevedo Batista ; Douglas Wagner Franco ; Roberto Santana da Silva
• Associated scholarship(s): 10/10674-0 - Evaluation of the ability to prevent restenosis and endothelialization promotion through biological activity of new materials eluting nitric oxide, BP.PD; 08/09935-4 - Biological activity of ruthenium complexes as Nitric oxide donor agents in neoplasic cell lines. Chemical, photochemical and citotoxic aspects, BP.DR

Abstract

This proposal focuses on the chemical and/or photochemical release of NO and the reactivity of complexes involving nitric oxide (NO) and related species such as nitrite and nitroxyl. Previous studies have concentrated on fundamental aspects of synthesis and chemical and photochemical reactivities of ruthenium nitrosyls, with some studies on their biological activity. Highlights of the present proposal include a deeper investigation of previously studied fundamental issues, such as: studies of reactions of nucleophilic attack of hydroxide ion on coordinated nitrosyls in ruthenium complexes with NO; photochemical studies directed to mechanistic aspects; development of complexes able to release NO with irradiation with light of the red region of the spectrum, and, thus, potentially useful in photodynamic therapy (PDT); along with other issues which are detailed in the proposal. Other important aspect worth to mention is the study of immobilized complexes, in the search for NO donors’ materials, directly or via nitrite to NO conversion, taking into account that nitrita is present in mammalian species. Other highlight of the proposal is the study of complexes involving other biologically important species, the nitroxyl ion (NO-), a very recent issue that needs investigation. All systems of these topics were conceived having in mind potential biological applications of the synthesized complexes. The proposal also aims at specific and controlled NO delivery, since NO can be either benefitial or harmful, depending on its concentration. Thus, specificity and delivery control are important factors taken into consideration in the design of the studied and proposed systems. As a result of work done so far, it can be noticed in the present proposal a large percentage of studies with potential biological applications, such as, for example, Chagas disease, Leishmaniosis, aorta rings relaxation, and anti-tumor activity. (AU)

Scientific publications

(10)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DORO, FABIO GORZONI; FERREIRA, KLEBER QUEIROZ; DA ROCHA, ZENIS NOVAIS; CARAMORI, GIOVANNI FINOTO; GOMES, ANDERSON JESUS; TFOUNI, ELIA. The versatile ruthenium(II/III) tetraazamacrocycle complexes and their nitrosyl derivatives. Coordination Chemistry Reviews, v. 306, n. 2, SI, p. 652-677, JAN 1 2016. (06/53266-4)

MELO PEREIRA, JOSE CLAYSTON; CARREGARO, VANESSA; COSTA, DIEGO LUIS; DA SILVA, JOAO SANTANA; CUNHA, FERNANDO Q.; FRANCO, DOUGLAS WAGNER. Antileishmanial activity of ruthenium(II)tetraammine nitrosyl complexes. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 45, n. 9, p. 4180-4187, SEP 2010. (06/53266-4)

DORO, F. G.; RAMOS, A. P.; SCHNEIDER, J. F.; RODRIGUES-FILHO, U. P.; VEIGA, M. A. M. S.; YANO, C. L.; NEGRETI, A.; KRIEGER, M. H.; TFOUNI, E.. Deposition of organic-inorganic hybrid coatings over 316L surgical stainless steel and evaluation on vascular cells. Canadian Journal of Chemistry, v. 92, n. 10, p. 987-995, OCT 2014. (11/07376-0, 10/10674-0, 06/53266-4)

VIDAL, ROBSON DA SILVA; DORO, FABIO GORZONI; FERREIRA, KLEBER QUEIROZ; DA ROCHA, ZENIS NOVAIS; CASTELLANO, EDUARDO ERNESTO; NIKOLAOU, SOFIA; TFOUNI, ELIA. Cis-trans isomerization in the syntheses of ruthenium cyclam complexes with nitric oxide. Inorganic Chemistry Communications, v. 15, p. 93-96, JAN 2012. (06/53266-4)

BORDINI, JEANE; CALANDRELI, IVY; SILVA, GISDELIA O.; FERREIRA, KLEBER Q.; LEITAO-MAZZI, DENISE P. S.; ESPREAFICO, ENILZA M.; TFOUNI, ELIA. A rhodamine-B-based turn-on fluorescent sensor for biological iron(III). Inorganic Chemistry Communications, v. 35, p. 255-259, SEP 2013. (06/53266-4)

ORENHA, RENATO PEREIRA; TFOUNI, ELIA; GALEMBECK, SERGIO EMANUEL. How does the total charge and isomerism influence the Ru-NO ammine complexes?. Physical Chemistry Chemical Physics, v. 20, n. 19, p. 13348-13356, MAY 21 2018. (11/20351-7, 08/02677-0, 15/15176-2, 06/53266-4, 14/50265-3)

CONCEICAO-VERTAMATTI, ANA GABRIELA; BORGHI, FILIPY; CANOVA, FERNANDO; GRASSI-KASSISSE, DORA MARIA. History of vascular reactivity models and their involvement in hypertension pathogenesis. Vasa-European Journal of Vascular Medicine, v. 46, n. 6, p. 431-439, OCT 2017. (06/53266-4)

DO PRADO, THIAGO M.; CINCOTTO, FERNANDO H.; MACHADO, SERGIO A. S.. Spectroelectrochemical study of acetylsalicylic acid in neutral medium and its quantification in clinical and environmental samples. Electrochimica Acta, v. 233, p. 105-112, APR 10 2017. (13/17053-0, 16/16565-5, 06/53266-4)

DE OLIVEIRA, MARIANA G.; DORO, FABIO G.; TFOUNI, ELIA; KRIEGER, MARTA H.. Phenotypic switching prevention and proliferation/migration inhibition of vascular smooth muscle cells by the ruthenium nitrosyl complex trans-[Ru(NO)Cl(cyclam](PF6)(2). Journal of Pharmacy and Pharmacology, v. 69, n. 9, p. 1155-1165, SEP 2017. (11/07376-0, 06/53266-4)

DORO, FABIO GORZONI; FERREIRA, KLEBER QUEIROZ; DA ROCHA, ZENIS NOVAIS; CARAMORI, GIOVANNI FINOTO; GOMES, ANDERSON JESUS; TFOUNI, ELIA. The versatile ruthenium(II/III) tetraazamacrocycle complexes and their nitrosyl derivatives. Coordination Chemistry Reviews, v. 306, p. 26-pg., 2016-01-01. (06/53266-4)