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Analyses of the distribution and the chemical coding of the P2X2 and P2X7 purine receptors in the ileum and distal colon enteric nervous system of the obese mice

Grant number: 05/04752-0
Support type:Regular Research Grants
Duration: August 01, 2006 - August 31, 2008
Field of knowledge:Biological Sciences - Morphology - Anatomy
Principal researcher:Patricia Castelucci
Grantee:Patricia Castelucci
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The intestinal functions like motility, secretion and absorption are coordinate by enteric nervous system and dysfunctions of the motility are observed in the obese people. However there is not information about of effects of the obesity in the P2X2 and P2X7 receptor of the enteric nervous system. This work has objective to analyse the chemical coding and distribution of the P2X2 and P2X7 receptor in the ob/ob mice. The tissue from ileum and distal colon will be used for histochemical and immunohistochemical methods to identification of the chemical coding with P2X2 and P2X7 receptors with nitric oxide sinthase (NOS), calbindin, calretinin, acetyl choline transferase and others neurotransmiters of the enteric neurons. The analyses will be done in the fluorescense and optical microscopy and the scanning laser confocal. The dates will are analysed by statisctical analysis. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MIZUNO, MARCIA SANAE; CRISMA, AMANDA RABELLO; BORELLI, PRIMAVERA; SCHAEFER, BARBARA TAVARES; SILVEIRA, MARIANA POVOA; CASTELUCCI, PATRICIA. Distribution of the P2X2 receptor and chemical coding in ileal enteric neurons of obese male mice (ob/ob). WORLD JOURNAL OF GASTROENTEROLOGY, v. 20, n. 38, p. 13911-13919, . (05/04752-0)
PAULINO, ARIANE SILVA; PALOMBIT, KELLY; CAVRIANI, GABRIELA; TAVARES-DE-LIMA, WOTHAN; MIZUNO, MARCIA SANAE; MAROSTI, ALINE ROSA; DA SILVA, MARCOS VINICIUS; GIROTTI, PRISCILA AZEVEDO; LIBERTI, EDSON APARECIDO; CASTELUCCI, PATRICIA. Effects of Ischemia and Reperfusion on P2X(2) Receptor Expressing Neurons of the Rat Ileum Enteric Nervous System. Digestive Diseases and Sciences, v. 56, n. 8, p. 2262-2275, . (05/04752-0)

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