| Grant number: | 06/06059-3 |
| Support Opportunities: | Regular Research Grants |
| Start date: | January 01, 2007 |
| End date: | December 31, 2008 |
| Field of knowledge: | Physical Sciences and Mathematics - Chemistry |
| Principal Investigator: | Carmen Lucia Queiroga |
| Grantee: | Carmen Lucia Queiroga |
| Host Institution: | Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA). Universidade Estadual de Campinas (UNICAMP). Paulínia , SP, Brazil |
Abstract
This project will evaluate the anti-inflammatory activity of the fractions from Pfaffia spp. roots extract. Based in the results we can evaluate if this biological activity is or is not associated with beta-ecdysone or another compound. The project in process involves the purification of Pfaffia glomerata roots extract (specie more cultivated currently in Brazil); the use of the Surface Tension (ST) analysis to find saponin fractions, obtaining fraction enriched with beta-edysone and the anti-inflammatory activity evaluation of fractions. CPQBA is the only producer of Pfaffia paniculata, and this project seeks to purify Pffafia paniculata extract, to evaluate the anti-inflammatory activity of its fractions and to verify if there are similar parameters among the behavior of the species. This project will allow to confirm if beta-ecdysone (reference compound) employed in HPLC analysis of Pfaffia spp. is or not is associated with the anti-inflammatory activity. (AU)
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