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Evaluation of the saponin antiinflammatory activity of Pfaffia spp.

Grant number: 06/06059-3
Support type:Regular Research Grants
Duration: January 01, 2007 - December 31, 2008
Field of knowledge:Physical Sciences and Mathematics - Chemistry
Principal Investigator:Carmen Lucia Queiroga
Grantee:Carmen Lucia Queiroga
Home Institution: Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA). Universidade Estadual de Campinas (UNICAMP). Paulínia , SP, Brazil


This project will evaluate the anti-inflammatory activity of the fractions from Pfaffia spp. roots extract. Based in the results we can evaluate if this biological activity is or is not associated with beta-ecdysone or another compound. The project in process involves the purification of Pfaffia glomerata roots extract (specie more cultivated currently in Brazil); the use of the Surface Tension (ST) analysis to find saponin fractions, obtaining fraction enriched with beta-edysone and the anti-inflammatory activity evaluation of fractions. CPQBA is the only producer of Pfaffia paniculata, and this project seeks to purify Pffafia paniculata extract, to evaluate the anti-inflammatory activity of its fractions and to verify if there are similar parameters among the behavior of the species. This project will allow to confirm if beta-ecdysone (reference compound) employed in HPLC analysis of Pfaffia spp. is or not is associated with the anti-inflammatory activity. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BITENCOURT, RAPHAELA G.; QUEIROGA, CARMEN L.; MONTANARI JUNIOR, ILIO; CABRAL, FERNANDO A. Fractionated extraction of saponins from Brazilian ginseng by sequential process using supercritical CO2, ethanol and water. JOURNAL OF SUPERCRITICAL FLUIDS, v. 92, p. 272-281, AUG 2014. Web of Science Citations: 24.

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