| Grant number: | 06/06736-5 |
| Support Opportunities: | Regular Research Grants |
| Start date: | February 01, 2007 |
| End date: | January 31, 2009 |
| Field of knowledge: | Biological Sciences - Biology |
| Principal Investigator: | Cristina Pacheco Soares |
| Grantee: | Cristina Pacheco Soares |
| Host Institution: | Instituto de Pesquisa e Desenvolvimento (IP&D). Universidade do Vale do Paraíba (UNIVAP). São José dos Campos , SP, Brazil |
Abstract
Photodynamic therapy (PDT) is a treatment modality for application in both neoplasic and non-neoplasic diseases.PDT involves a light-sensitive compound (photosensitizer), light and molecular oxigen. This prosedure can lead to several different cellular responses, including cellular death. Alteration in attachment of cancer cells to the substratum and each other are amonsgt important consequences of photodynamic treatment. PDT has been revealed to lead changes in the expression of cellular adhesion structure and cytoskeleton integrity, key factors in the decrease of tumor metastatic potential. The present project aim to analyze changes in expression and organization of cellular adhesion elements and in the meatastatic potential after PDT using Chloroaluminum phthalocyanine liposomal (AlPHCl liposomal). (AU)
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