Research Grants 06/06736-5 - Biologia celular, Células tumorais - BV FAPESP
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Expression and organization of cellular adhesion elements after PDT

Abstract

Photodynamic therapy (PDT) is a treatment modality for application in both neoplasic and non-neoplasic diseases.PDT involves a light-sensitive compound (photosensitizer), light and molecular oxigen. This prosedure can lead to several different cellular responses, including cellular death. Alteration in attachment of cancer cells to the substratum and each other are amonsgt important consequences of photodynamic treatment. PDT has been revealed to lead changes in the expression of cellular adhesion structure and cytoskeleton integrity, key factors in the decrease of tumor metastatic potential. The present project aim to analyze changes in expression and organization of cellular adhesion elements and in the meatastatic potential after PDT using Chloroaluminum phthalocyanine liposomal (AlPHCl liposomal). (AU)

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VANESSA DOS SANTOS SILVA; ELIZÂNGELA MÁRCIA DE CARVALHO ABREU; RENATA AMADEI NICOLAU; CRISTINA PACHECO SOARES. Comparative analysis of different doses of coherent light (laser) and non-coherent light (light-emitting diode) on cellular necrosis and apoptosis: a study in vitro. Res. Biomed. Eng., v. 32, n. 4, p. 372-379, . (06/06736-5)
ARAUJO MACHADO, ALINE HELENA; MORAES, KAREN C. M.; SOARES, CRISTINA PACHECO; BELTRAME JUNIOR, MILTON; DA SILVA, NEWTON SOARES. Cellular Changes After Photodynamic Therapy on HEp-2 Cells Using the New ZnPcBr8 Phthalocyanine. Photomedicine and Laser Surgery, v. 28, p. 7-pg., . (06/06736-5)
ARAUJO MACHADO, ALINE HELENA; MORAES, KAREN C. M.; SOARES, CRISTINA PACHECO; BELTRAME JUNIOR, MILTON; DA SILVA, NEWTON SOARES. Cellular Changes After Photodynamic Therapy on HEp-2 Cells Using the New ZnPcBr8 Phthalocyanine. Photomedicine and Laser Surgery, v. 28, n. 1, p. S143-S149, . (06/06736-5)
PACHECO-SOARES, CRISTINA; MAFTOU-COSTA, MAIRA; DA CUNHA MENEZES COSTA, CAROLINA GENUNCIO; DE SIQUEIRA SILVA, ANDREZA CRISTINA; MORAES, KAREN C. M.. Evaluation of photodynamic therapy in adhesion protein expression. Oncology Letters, v. 8, n. 2, p. 714-718, . (06/06736-5)
SOARES, CRISTINA PACHECO; LEMOS, VALERIA ROSSETO; DA SILVA, ARY GOMES; CAMPOY, RENAN MEYER; PRIANTE DA SILVA, CARLOS AUGUSTO; MENEGON, RENATO FARINA; ROJAHN, IURI; JOAQUIM, WALDEREZ MOREIRA. Effect of Spilanthes acmella hydroethanolic extract activity on tumour cell actin cytoskeleton. Cell Biology International, v. 38, n. 1, p. 131-135, . (06/06736-5)

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