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Mammary carcinogenesis induced by DMBA in genetically modified mice, deficient in Cx43

Grant number: 10/08480-3
Support type:Regular Research Grants
Duration: August 01, 2010 - July 31, 2012
Field of knowledge:Agronomical Sciences - Veterinary Medicine
Principal Investigator:Maria Lucia Zaidan Dagli
Grantee:Maria Lucia Zaidan Dagli
Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Gap junctions are communicating protein channels of the cell membrane, formed by proteins called connexins. The functional loss of the gap junctions has been correlated with the process of carcinogenesis, through the reduction in the communication capacity and alterations of the expression and localization of connexins. The DMBA is a carcinogen that triggers the development of mammary neoplasms, and has been used to the creation of chemical carcinogenesis models in mice. The aim of this project is to study the interference of the absence of one of the alleles of Cx43 gene in mammary carcinogenesis induced by DMBA. For this purpose, it is intended to administrate 9 mg/kg /mice, being 1 mg / week, to female mice Cx43 +/- or Cx43 +/+. The evaluation of the interference in the process will be done by the qualitative and quantitative analysis of the tumors, immunohistochemistry, Real-Time PCR and Western Blot. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE OLIVEIRA, KRISHNA DURO; TEDARDI, MARCELLO VANNUCCI; COGLIATI, BRUNO; ZAIDAN DAGLI, MARIA LUCIA. Higher Incidence of Lung Adenocarcinomas Induced by DMBA in Connexin 43 Heterozygous Knockout Mice. BIOMED RESEARCH INTERNATIONAL, 2013. Web of Science Citations: 11.

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