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Evaluation of the expression of receptors for estrogen, progesteron, E-cadherin, cytokeratins 5 and 14, vimentin, c-kit, PCNA and PTEN in mammary neoplasms induced by DMBA in BALB/c mice

Grant number: 10/00874-2
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): April 01, 2010
Effective date (End): March 31, 2011
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Pathology
Principal researcher:Maria Lucia Zaidan Dagli
Grantee:Marcello Vannucci Tedardi
Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil


DMBA is a carcinogen that induces the development of mammary neoplasms and has been used in models of chemical carcinogenesis in mice. A previous study performed at the Experimental and Comparative Oncology Lab at the Dept of Pathology of the School of Vet medicine and Animal Science of the USP has shown that doses of 1, 3, 6 and 9 mg per mouse induce mammary neoplasms in Balb/c mice. However, we know very little about these tumors. The objective of this project is to study the expression of receptors for estrogen, progesterone, e-cadherine, cytokeratins 5 and 14, vimentin, c-kitm PTEN and cell proliferation by immunohistochemistry. Tumors will be classified according to WHO and will be submitted to immunohistochemistry. We intend to better characterize these tumors and compare them with human or canine neoplasms. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE OLIVEIRA, KRISHNA DURO; TEDARDI, MARCELLO VANNUCCI; COGLIATI, BRUNO; ZAIDAN DAGLI, MARIA LUCIA. Higher Incidence of Lung Adenocarcinomas Induced by DMBA in Connexin 43 Heterozygous Knockout Mice. BIOMED RESEARCH INTERNATIONAL, 2013. Web of Science Citations: 11.

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