Effectors and immunoregulatory mechanisms in demyelinating diseases induced in human and experimental models

• Grant number: 09/18227-6
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2010
• End date: September 30, 2012
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Leonilda Maria Barbosa dos Santos
• Grantee: Leonilda Maria Barbosa dos Santos
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The multiple sclerosis (MS) as well as its experimental model Experimental autoimmune encephalomyelitis (EAE) are known as demyelinating diseases caused by T CD4 lymphocytes Th1 and Th17.The autoreactive T lymphocytes are generated in the periphery and migrate do the central nervous system (CNS) where they initiated the demyelination process. The autoreactive T lymphocytes produce or are stimulated by proinflammatory cytokines such as IL-17 and osteopontin.On the other hand, regulatory T cells that produced antiinflammatory cytokines such as TGFbeta and IL-10 downregulated the inflammatory process caused by the effector T cells. Cells from the innate arm of immune response such as plasmacytoid dendritic cells can either stimulated or downregulated the effect T lymphocytes. The plasmacytoid dendritic cells produce high level of indoleamine, 2,3 dioxigenase that mediated the tolerogenic function of T cells. Here, the effect of plasmacytoid dendritic cells on effector and in downregulation of autoreactive T cells will be studied either in MS patients or in the animal model (EAE). The antibody to aquaporin 4 in the serum and CSF of patients with NMO and MS. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FARIAS, ALESSANDRO S.; MARTINS-DE-SOUZA, DANIEL; GUIMARAES, LEANDRO; PRADELLA, FERNANDO; MORAES, ADRIEL S.; FACCHINI, GUSTAVO; NOVELLO, JOSE CAMILLO; SANTOS, LEONILDA M. B.. Proteome analysis of spinal cord during the clinical course of monophasic experimental autoimmune encephalomyelitis. PROTEOMICS, v. 12, n. 17, p. 7-pg., 2012-08-01. (09/18227-6, 11/18728-5, 09/15620-9)

FARIAS, ALESSANDRO S.; MARTINS-DE-SOUZA, DANIEL; GUIMARAES, LEANDRO; PRADELLA, FERNANDO; MORAES, ADRIEL S.; FACCHINI, GUSTAVO; NOVELLO, JOSE CAMILLO; SANTOS, LEONILDA M. B.. Proteome analysis of spinal cord during the clinical course of monophasic experimental autoimmune encephalomyelitis. PROTEOMICS, v. 12, n. 17, SI, p. 2656-2662, AUG 2012. (09/15620-9, 09/18227-6, 11/18728-5)