|Support type:||Scholarships in Brazil - Doctorate|
|Effective date (Start):||October 01, 2012|
|Effective date (End):||February 29, 2016|
|Field of knowledge:||Biological Sciences - Immunology - Cellular Immunology|
|Principal Investigator:||Leonilda Maria Barbosa dos Santos|
|Grantee:||Adriel dos Santos Moraes|
|Home Institution:||Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil|
The HLA-G molecules, expressed in cells or soluble, are described as critical for the induction of immunological tolerance. These molecules are expressed in many cell types and are involved in the induction of regulatory T lymphocytes. In this study we intend to analyze the regulatory function of HLA-G both in patients with multiple sclerosis (MS) treated with immunomodulators, such as the experimental model of this disease experimental autoimmune encephalitis (EAE). In MS, we want to study the HLA-G expressed plasmacytoid dendritic cells present in cerebrospinal fluid (CSF) at different stages of the disease, and peripheral blood in the process of induction of regulatory T lymphocytes. In EAE, we attempted to verify if the HLA-G are expressed in neurons at different stages of the disease induced in Lewis rats. If so, we intend to investigate how these molecules act in the interaction with T lymphocytes encephalitogen.