Effects of exercise program, performance and quality of life in dialysis patients

• Grant number: 08/05473-6
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2008
• End date: October 31, 2010
• Field of knowledge: Health Sciences - Physiotherapy and Occupational Therapy
• Agreement: CNPq - PPSUS
• Principal Investigator: Regina Coeli Vasques de Miranda Burneiko
• Grantee: Regina Coeli Vasques de Miranda Burneiko
• Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil

Abstract

Chronic renal failure (CRF) is considered a global public health problem. In the world about 1.2 million people are under hemodialysis treatment. In Brazil there are approximately 54.5 million people, of these, 48,875 in hemodialysis and 5,649 in peritoneal dialysis. The patient with CRF has low tolerance for exercise and as a result presents functional limitations inducing negative impacts on his quality of life. The questionnaire Kidney Disease and Quality-of-Life Short Form (KDQOL-SF), for specific individuals in hemodialysis treatment, can be applied to quantify the impact of the disease in these patients. Aims: To assess the effects of a 8-week physical activity program over the function ability and quality of life on patients in hemodialysis. Methodology: 40 patients of both genders will be selected, between 40 and 60 years old in the hemodialysis program at the Kidney Institute of Santa Casa de Misericórdia of Presidente Prudente-SP. Patients will be randomly divided into two groups of 20 patients each. Group 1 will be the experimental group, Group 2 will be the control group. Both groups (40 patients) will be initially submitted to standard clinical evaluation (vital signs and oxygen saturation) and the results of the laboratory tests registered on records will be collected. In continuity, both groups will begin the evaluation of lung function for analysis of forced vital capacity, forced expiratory volume in the first second and Tiffeneau index. Assessment of muscle strength inspiratory (PImax) and expiratory (PEmax), assessment of functional capacity through the test of Six Minute Walk (TC6min) and assessment of the quality of life through the KDQOL-SF. After these evaluations, the group 1 (trial) will initiate a program of physical activity, during 8 weeks, held 3 times a week for 40 minutes during the sessions of dialysis. Group 2 (control) will remain under observation, under dialysis treatment and with their usual activities of daily life. At the end of the programme of physical exercises, both groups will be reassessed. Studente t test will be used for the analysis of the paired data. The correlation coefficient of Spearman will be used for the association between lung function and respiratory muscle strength. In situations where the normal distribution is not accepted, the Mann-Whitney test will be applied. Differences in these tests will be considered statistically significant when the value of "p" is less than 0.05. (AU)