Assessment of thromboembolic risk and, renal and hematological complications in dogs with IMHA

• Grant number: 08/10427-3
• Support Opportunities: Regular Research Grants
• Duration: July 01, 2009 - June 30, 2011
• Field of knowledge: Agronomical Sciences - Veterinary Medicine
• Principal Investigator: Regina Kiomi Takahira
• Grantee: Regina Kiomi Takahira
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Immune-mediated hemolytic anemia (IMHA) is the most common cause of hemolytic anemia and the most prevalent immune-mediated disease in dogs, which is classified in primary or secondary. IMHA has been associated with hypercoagulability state and pulmonary thromboembolism has been referred as the most frequent cause of death. The high frequency of hemostatic abnormalities supports the importance of an early, effective and more accurate diagnosis, along with a preventive strategy and treatment. Then, the objectives of this project are: to value the incident of hemostatic abnormalities, renal and hematological complications and the prevalence of the classes of immunoglobulins are involved. For this purpose, will be selected 100 adult dogs with hematocrit less than 20%, without a history of recent treatment with corticoid or transfusion and presenting at least one clinical or laboratorial sign (hepato, esplenomegalia, ictericia, dispneia, taquicardia, pirexia, spherocytes, auto-agglutination, hyperbilirrubinemia, hemoglobinemia, hyperproteinemia, hyperglobulinemia, hemoglobinuria) commonly associated with IMHA, or with racial predisposition will be selected, excluding animals with com Chronic Renal Failure, Aplastic Bone Marrow induced by drugs and worm infestation. These dogs will be tested by direct anti-globulin test, flow cytometric and auto-agglutination for diagnostic of IMHA. CBC, reticulocyte count, hemostatic and renal tests, blood parasite search in peripheral blood and Ehrlichia canis and leptospirosis tests will be performed in the positive cases for any of that tests. The results will be analyzed by t test or Mann-Whitney with 5% of significance. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MORAES, LIVIA FAGUNDES; TAKAHIRA, REGINA KIOMI; GOLIM, MARJORIE DE ASSIS. . Acta Scientiae Veterinariae, v. 45, NOV 26 2017. (08/10427-3)

LÍVIA F. MORAES; REGINA K. TAKAHIRA; MARJORIE DE A. GOLIM; MÁRCIA S. BAGGIO. Avaliação das alterações hemostáticas e do risco tromboembólico em cães com AHIM. Pesquisa Veterinária Brasileira, v. 36, n. 5, p. 405-411, 2016-05-00. (08/10427-3)