Effects of cold stress on phagocytosis by macrophages and polimorphonuclear leucocytes

• Grant number: 10/00820-0
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2010
• End date: October 31, 2012
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Bernardo Mantovani
• Grantee: Bernardo Mantovani
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated researchers: Renata Sesti Costa ; Silvana Chedraoui Silva

Abstract

In this investigation we study: (a) The influence of chronic cold stress on mice in phagocytosis by macrophages mediated by different types of receptor: FcgammaR; CR1 and CR3, lectin and for apoptotic cells. It will also be assayed the release of pro-inflamatory and antiinflamatory cytokines and reactive oxygen species. (b) The effects of acute cold stress of 4 h on phagocytosis by mouse polymorphonuclear leucocytes (PMN). (c) The possible effects of stress hormones, specially corticosterone, on the phagocytic capacity of cytoplasts prepared from macrophages and PMN. (AU)