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Skeletal muscle remodeling induced by blood flow restriction plus low-intensity strength training: the role neutrophils/macrophages recruitment

Grant number: 15/23910-8
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): March 01, 2017
Effective date (End): May 31, 2017
Field of knowledge:Health Sciences - Physical Education
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Fábio Santos de Lira
Grantee:Fabrício Eduardo Rossi
Home Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil

Abstract

The blood flow restriction combined with low-intensity strength training (BFR) has been shown to increase muscle size and strength in different population. The high metabolic stress induced by BFR is hypothesize to induce muscle growth by increased recruitment of fast- twitch muscle fibres, systemic hormones, cell swelling increasing hypertrofic process. The inflammatory response, mainly neutrophils are the first immune cells to initiate starting tissue remodeling process stimulated by various mechanisms, such as increased production of cytokines, reactive oxygen species, recruitment of monocytes/macrophages can facilitate the phagocytosis of foreign particles, the differentiation of myoblasts and the formation of new myotubules, however, unknown the inflammatory response after acute and chronic BFR. Thus, this study will verify the inflammatory response (systemic cytokine and cytokine in the skeletal muscle) during blood flow restriction plus low-intensity strength training. 15 male subjects between 18 to 35 years old will be recruiting. Muscle biopsies will be obtain from muscle vastus lateralis before and after eight weeks of training (pre, post-3 hours of exercise and post-24 hours into recovery) and blood sample will collect: 1st and after 8th week (pre, immediately post exercise, post-15 minutes, post-30 minutes, post-60 minutes and post-24 h into recovery). Blood flow restriction will allocate to one leg, while traditional high-intensity strength training will allocate to the other leg. The comparison between legs will perform by two-way repeated measure of Anova. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LIRA, FABIO S.; CONRADO DE FREITAS, MARCELO; GEROSA-NETO, JOSE; CHOLEWA, JASON M.; ROSSI, FABRICIO E. Comparison Between Full-Body vs. Split-Body Resistance Exercise on the Brain-Derived Neurotrophic Factor and Immunometabolic Response. JOURNAL OF STRENGTH AND CONDITIONING RESEARCH, v. 34, n. 11, p. 3094-3102, NOV 2020. Web of Science Citations: 4.
FREITAS, MARCELO C.; CHOLEWA, JASON M.; GEROSA-NETO, JOSE; GONCALVES, DANIELA C.; CAPERUTO, ERICO C.; LIRA, FABIO S.; ROSSI, FABRICIO E. A SINGLE DOSE OF ORAL ATP SUPPLEMENTATION IMPROVES PERFORMANCE AND PHYSIOLOGICAL RESPONSE DURING LOWER BODY RESISTANCE EXERCISE IN RECREATIONAL RESISTANCE-TRAINED MALES. JOURNAL OF STRENGTH AND CONDITIONING RESEARCH, v. 33, n. 12, p. 3345-3352, DEC 2019. Web of Science Citations: 3.
ROSSI, FABRICIO EDUARDO; DE FREITAS, MARCELO CONRADO; ZANCHI, NELO EIDY; LIRA, FABIO SANTOS; CHOLEWA, JASON M. The Role of Inflammation and Immune Cells in Blood Flow Restriction Training Adaptation: A Review. FRONTIERS IN PHYSIOLOGY, v. 9, OCT 9 2018. Web of Science Citations: 1.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.