Determinantes e consequencias das infeccoes assintomaticas por plasmodios: estudos de base populacional na amazonia rural brasileira.

• Grant number: 09/52729-9
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2009
• End date: September 30, 2011
• Field of knowledge: Health Sciences - Collective Health - Epidemiology
• Principal Investigator: Marcelo Urbano Ferreira
• Grantee: Marcelo Urbano Ferreira
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• City of the host institution: São Paulo

Abstract

Despite five decades of intensive control efforts, malaria remains a major public health concern in Brazil. The most recent incidence data available are for 2007, when 458,041 slide-confirmed malaria cases were reported countrywide, 99.9% of which acquired in the Amazon Basin. The increasing interest oh malaria epidemiology in Brazil originates mainly from the high morbidity observed in exposed populations, but subclinical malaria infections are also a major target of research. Here we focus on the epidemiology of asymptomatic malarial infections in two different settings in Brazil: (a) traditional riverine communities and agricultural settlements. We aim to: (a) estimate the prevalence of asymptomatic malaria parasite carriage and characterize risk factors for clinical disease among parasite carriers; (b) estimate the prevalence and risk factors for gametocyte carriage in symptomatic and asymptomatic infections; (c) estimate the risk of subsequent clinical malaria among asymptomatic parasite carriers and non-infected subjects; (d) determine whether subsequent clinical malaria episodes diagnosed during the follow-up of asymptomatic parasite carriers are associated with persistent parasite lineages or with infections with unrelated parasites; (e) compare levels of genetic diversity in parasites recovered from symptomatic and asymptomatic infections. (AU)

Scientific publications

(10)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

URUSOVA, DARYA; CARIAS, LENORE; HUANG, YINING; NICOLETE, VANESSA C.; POPOVICI, JEAN; ROESCH, CAMILLE; SALINAS, NICHOLE D.; WITKOWSKI, BENOIT; FERREIRA, MARCELO U.; ADAMS, JOHN H.; et al. Structural basis for neutralization of Plasmodium vivax by naturally acquired human antibodies that target DBP. NATURE MICROBIOLOGY, v. 4, n. 9, p. 1486-1496, SEP 2019. (09/52729-9)

LIMA, NATHALIA F.; BASTOS, MELISSA S.; FERREIRA, MARCELO U.. Plasmodium vivax: Reverse transcriptase real-time PCR for gametocyte detection and quantitation in clinical samples. Experimental Parasitology, v. 132, n. 3, p. 348-354, NOV 2012. (09/52729-9)

BARBOSA, SUSANA; GOZZE, AMANDA B.; LIMA, NATHALIA F.; BATISTA, CAMILLA L.; BASTOS, MELISSA DA SILVA; NICOLETE, VANESSA C.; FONTOURA, PABLO S.; GONCALVES, RAQUEL M.; VIANA, SUSANA ARIANE S.; MENEZES, MARIA JOSE; et al. Epidemiology of Disappearing Plasmodium vivax Malaria: A Case Study in Rural Amazonia. PLoS Neglected Tropical Diseases, v. 8, n. 8, AUG 2014. (09/52729-9, 13/23770-6, 13/17259-7, 09/12180-8)

NICOLETE, VANESSA C.; FRISCHMANN, SARAH; BARBOSA, SUSANA; KING, CHRISTOPHER L.; FERREIRA, MARCELO U.. Naturally Acquired Binding-Inhibitory Antibodies to Plasmodium vivax Duffy Binding Protein and Clinical Immunity to Malaria in Rural Amazonians. Journal of Infectious Diseases, v. 214, n. 10, p. 1539-1546, NOV 15 2016. (09/52729-9, 13/23770-6)

CARIAS, LENORE L.; DECHAVANNE, SEBASTIEN; NICOLETE, VANESSA C.; SRENG, SOKUNTHEA; SUON, SEILA; AMARATUNGA, CHANAKI; FAIRHURST, RICK M.; DECHAVANNE, CELIA; BARNES, SAMANTHA; WITKOWSKI, BENOIT; et al. Identification and Characterization of Functional Human Monoclonal Antibodies to Plasmodium vivax Duffy-Binding Protein. JOURNAL OF IMMUNOLOGY, v. 202, n. 9, p. 2648-2660, MAY 1 2019. (09/52729-9)

SHAW-SALIBA, KATHRYN; CLARKE, DAVID; SANTOS, JORGE M.; MENEZES, MARIA JOSE; LIM, CAEUL; MASCARENHAS, ANJALI; CHERY, LAURA; GOMES, EDWIN; MARCH, SANDRA; BHATIA, SANGEETA N.; et al. Infection of laboratory colonies of Anopheles mosquitoes with Plasmodium vivax from cryopreserved clinical isolates. International Journal for Parasitology, v. 46, n. 11, p. 679-683, OCT 2016. (09/52729-9)

DE PAULA, FABIANA M.; GOMES, BRUNA B.; MEISEL, DIRCE MARY C. L.; NUNES, MONICA DA-SILVA; CAVASINI, CARLOS E.; SCOPEL, KEZIA K. G.; GRYSCHEK, RONALDO C. B.; FERREIRA, MARCELO U.. Dynamics of anti-Strongyloides IgG antibody responses and implications for strongyloidiasis surveillance in rural Amazonians: A population-based panel data analysis. PLoS Neglected Tropical Diseases, v. 19, n. 4, p. 15-pg., 2025-04-01. (13/04236-9, 09/52729-9, 22/02401-1)

FERREIRA, MARCELO U.; CASTRO, MARCIA C.. Challenges for malaria elimination in Brazil. Malaria Journal, v. 15, MAY 20 2016. (09/52729-9, 13/17259-7)

HUPALO, DANIEL N.; LUO, ZUNPING; MELNIKOV, ALEXANDRE; SUTTON, PATRICK L.; ROGOV, PETER; ESCALANTE, ANANIAS; VALLEJO, ANDRES F.; HERRERA, SOCRATES; AREVALO-HERRERA, MYRIAM; FAN, QI; et al. Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax. Nature Genetics, v. 48, n. 8, p. 953+, AUG 2016. (09/52729-9)

DA SILVA-NUNES, MONICA; MORENO, MARTA; CONN, JAN E.; GAMBOA, DIONICIA; ABELES, SHIRA; VINETZ, JOSEPH M.; FERREIRA, MARCELO U.. Amazonian malaria: Asymptomatic human reservoirs, diagnostic challenges, environmentally driven changes in mosquito vector populations, and the mandate for sustainable control strategies. Acta Tropica, v. 121, n. 3, p. 11-pg., 2012-03-01. (09/52729-9)