Chemical and pharmacological contribution to the Machaerium genera (Fabaceae)

• Grant number: 09/16147-5
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2010
• End date: October 31, 2012
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Miriam Sannomiya
• Grantee: Miriam Sannomiya
• Host Institution: Escola de Artes, Ciências e Humanidades (EACH). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Clélia Akiko Hiruma Lima ; Eliana Aparecida Varanda ; Wagner Vilegas

Abstract

The main of this project is contribute to the knowledge of the potentiality of the some Machaerium species from the Brazilian Cerrado by a chemical-pharmacological study, in other words, isolation and identification of the compounds presented in the vegetable extracts together with pharmacological assays to the antiulcer, anti-inflamatory/analgesic, anti-mutagenic and mutagenic activities. According to the literature, some Machaerium species (Fabaceae) are ethnopharmacologic used like as Machaerium hirtum (vell.) Stellfedl., it is a plant which barks are employed popularly against diarrhoea, cough and cancer. It is popularly known as "adolfo and bico-de andorinha". Despite of it, no data until now can be observed approaching the chemistry or pharmacological studies with this species. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RIBEIRO, DIEGO LUIS; CILIAO, HELOISA LIZOTTI; LEAL SPECIAN, ANA FLAVIA; SERPELONI, JULIANA MARA; DE SOUZA, MARILESIA FERREIRA; PEREIRA TANGERINA, MARCELO MARUCCI; VILEGAS, WAGNER; BOLDRIN, PAULA KARINA; RESENDE, FLAVIA APARECIDA; VARANDA, ELIANA APARECIDA; et al. Chemical and biological characterisation of Machaerium hirtum (Vell.) Stellfeld: absence of cytotoxicity and mutagenicity and possible chemopreventive potential. MUTAGENESIS, v. 31, n. 2, p. 147-160, MAR 2016. (09/52237-9, 10/04077-0, 09/16147-5)

RIBEIRO, DIEGO LUIS; CILIAO, HELOISA LIZOTTI; LEAL SPECIAN, ANA FLAVIA; SERPELONI, JULIANA MARA; DE OLIVEIRA, MARCELO TEMPESTA; VARANDA, ELIANA APARECIDA; VILEGAS, WAGNER; SALDANHA, LUIZ LEONARDO; MARTINEZ-LOPEZ, WILNER; DOKKEDAL, ANNE LIGIA; et al. Phytochemical study and evaluation of cytotoxicity, mutagenicity, cell cycle kinetics and gene expression of Bauhinia holophylla (Bong.) Steud. in HepG2 cells in vitro. Cytotechnology, v. 70, n. 2, p. 713-728, APR 2018. (12/01996-0, 09/52237-9, 09/16147-5)