Development of a bioprocess with S2 cells for production and purification of the recombinant rabies virus glycoprotein and study of its antigenicity

• Grant number: 09/09327-7
• Support type: Regular Research Grants
• Duration: February 01, 2010 - January 31, 2012
• Field of knowledge: Biological Sciences - Microbiology - Applied Microbiology
• Principal researcher: Carlos Augusto Pereira
• Grantee: Carlos Augusto Pereira
• Home Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

The aim of the present research project is to promote a collaborative work involving Laboratories of the Instituto Butantan and the Escola Politecnica of the University of São Paulo to study and establish a bioprocess for the synthesis and extraction of the recombinant rabies virus glycoprotein (GPV) with high productivity and immunologic quality from S2 Drosophila melanogaster cells cultivated in bioreactors. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ASTRAY, RENATO M.; VENTINI, DANIELLA C.; BOLDORINI, VERA L. L.; SILVA, FERNANDA G.; ROCCA, MAYRA P.; PEREIRA, CARLOS A. Rabies virus glycoprotein and immune response pattern using recombinant protein or recombinant RNA viral vectors. Vaccine, v. 32, n. 24, SI, p. 2829-2832, MAY 19 2014. Web of Science Citations: 6.