Characterization of antigen presenting cells capable of initiating the immune response and control the immunodominance during Trypanosoma cruzi infection

• Grant number: 09/06820-4
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2009
• End date: November 30, 2011
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Maurício Martins Rodrigues
• Grantee: Maurício Martins Rodrigues
• Host Institution: Centro de Terapia Celular e Molecular. Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Scientific publications

(13)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ARAUJO, ADRIANO FERNANDO; DE OLIVEIRA, GABRIEL; VASCONCELOS, JULIANA FRAGA; ERSCHING, JONATAN; DOMINGUEZ, MARIANA RIBEIRO; VASCONCELOS, JOSE RONNIE; MACHADO, ALEXANDRE VIEIRA; GAZZINELLI, RICARDO TOSTES; BRUNA-ROMERO, OSCAR; SOARES, MILENA BOTELHO; et al. Genetic Vaccination against Experimental Infection with Myotropic Parasite Strains of Trypanosoma cruzi. Mediators of Inflammation, 2014. (09/06820-4, 12/22514-3)

VIRGILIO, FERNANDO DOS SANTOS; PONTES, CAMILA; DOMINGUEZ, MARIANA RIBEIRO; ERSCHING, JONATAN; RODRIGUES, MAURICIO MARTINS; VASCONCELOS, JOSE RONNIE. CD8(+) T Cell-Mediated Immunity during Trypanosoma cruzi Infection: A Path for Vaccine Development?. Mediators of Inflammation, 2014. (13/13668-0, 09/06820-4, 12/22514-3)

DOMINGUEZ, MARIANA R.; ERSCHING, JONATAN; LEMOS, RAMON; MACHADO, ALEXANDRE V.; BRUNA-ROMERO, OSCAR; RODRIGUES, MAURICIO M.; DE VASCONCELOS, JOSE RONNIE C.. Re-circulation of lymphocytes mediated by sphingosine-1-phosphate receptor-1 contributes to resistance against experimental infection with the protozoan parasite Trypanosoma cruzi. Vaccine, v. 30, n. 18, p. 2882-2891, APR 16 2012. (09/06820-4)

DOMINGUEZ, MARIANA R.; SILVEIRA, EDUARDO L. V.; DE VASCONCELOS, JOSE RONNIE C.; DE ALENCAR, BRUNA C. G.; MACHADO, ALEXANDRE V.; BRUNA-ROMERO, OSCAR; GAZZINELLI, RICARDO T.; RODRIGUES, MAURICIO M.. Subdominant/cryptic CD8 T cell epitopes contribute to resistance against experimental infection with a human protozoan parasite. PLoS One, v. 6, n. 7, p. e22011, 2011. (09/06820-4)

VASCONCELOS, JOSE RONNIE; DOMINGUEZ, MARIANA R.; NEVES, RAMON L.; ERSCHING, JONATAN; ARAUJO, ADRIANO; SANTOS, LUARA I.; VIRGILIO, FERNANDO S.; MACHADO, ALEXANDRE V.; BRUNA-ROMERO, OSCAR; GAZZINELLI, RICARDO T.; et al. Adenovirus Vector-Induced CD8(+) T Effector Memory Cell Differentiation and Recirculation, But Not Proliferation, Are Important for Protective Immunity Against Experimental Trypanosoma cruzi Infection. Human Gene Therapy, v. 25, n. 4, p. 350-363, APR 1 2014. (09/06820-4, 12/22514-3)

ERSCHING, JONATAN; VASCONCELOS, JOSE R.; FERREIRA, CAMILA P.; CAETANO, BRAULIA C.; MACHADO, ALEXANDRE V.; BRUNA-ROMERO, OSCAR; BARON, MONIQUE A.; FERREIRA, LUDMILA R. P.; CUNHA-NETO, EDECIO; ROCK, KENNETH L.; et al. The Combined Deficiency of Immunoproteasome Subunits Affects Both the Magnitude and Quality of Pathogen- and Genetic Vaccination-Induced CD8(+) T Cell Responses to the Human Protozoan Parasite Trypanosoma cruzi. PLOS PATHOGENS, v. 12, n. 4, APR 2016. (10/09361-8, 15/08814-2, 09/06820-4, 12/22514-3)

VASCONCELOS, JOSE RONNIE; BRUNA-ROMERO, OSCAR; ARAUJO, ADRIANO F.; DOMINGUEZ, MARIANA R.; ERSCHING, JONATAN; DE ALENCAR, BRUNA C. G.; MACHADO, ALEXANDRE V.; GAZZINELLI, RICARDO T.; BORTOLUCI, KARINA R.; AMARANTE-MENDES, GUSTAVO P.; et al. Pathogen-Induced Proapoptotic Phenotype and High CD95 (Fas) Expression Accompany a Suboptimal CD8(+) T-Cell Response: Reversal by Adenoviral Vaccine. PLOS PATHOGENS, v. 8, n. 5, MAY 2012. (09/06820-4)

ERSCHING, JONATAN; BASSO, ALEXANDRE SALGADO; GARCIA KALICH, VERA LUCIA; BORTOLUCI, KARINA RAMALHO; RODRIGUES, MAURICIO M.. A Human Trypanosome Suppresses CD8(+) T Cell Priming by Dendritic Cells through the Induction of Immune Regulatory CD4(+) Foxp3(+) T Cells. PLOS PATHOGENS, v. 12, n. 6, JUN 2016. (12/13032-5, 09/06820-4, 12/22514-3)

VASCONCELOS, JOSE R.; DOMINGUEZ, MARIANA R.; ARAUJO, ADRIANO F.; ERSCHING, JONATAN; TARARAM, CIBELE A.; BRUNA-ROMERO, OSCAR; RODRIGUES, MAURICIO M.. Relevance of long-lived CD8(+) T effector memory cells for protective immunity elicited by heterologous prime-boost vaccination. FRONTIERS IN IMMUNOLOGY, v. 3, 2012. (09/06820-4)

RIGATO, PAULA ORDONHEZ; DE ALENCAR, BRUNA C.; DE VASCONCELOS, JOSE RONNIE C.; DOMINGUEZ, MARIANA R.; ARAUJO, ADRIANO F.; MACHADO, ALEXANDRE V.; GAZZINELLI, RICARDO T.; BRUNA-ROMERO, OSCAR; RODRIGUES, MAURICIO M.. Heterologous Plasmid DNA Prime-Recombinant Human Adenovirus 5 Boost Vaccination Generates a Stable Pool of Protective Long-Lived CD8(+) T Effector Memory Cells Specific for a Human Parasite, Trypanosoma cruzi. Infection and Immunity, v. 79, n. 5, p. 2120-2130, MAY 2011. (09/06820-4)

ARAUJO, ADRIANO FERNANDO; DE OLIVEIRA, GABRIEL; VASCONCELOS, JULIANA FRAGA; ERSCHING, JONATAN; DOMINGUEZ, MARIANA RIBEIRO; VASCONCELOS, JOSE RONNIE; MACHADO, ALEXANDRE VIEIRA; GAZZINELLI, RICARDO TOSTES; BRUNA-ROMERO, OSCAR; SOARES, MILENA BOTELHO; et al. Genetic Vaccination against Experimental Infection with Myotropic Parasite Strains of Trypanosoma cruzi. Mediators of Inflammation, v. 2014, p. 13-pg., 2014-01-01. (09/06820-4, 12/22514-3)

VIRGILIO, FERNANDO DOS SANTOS; PONTES, CAMILA; DOMINGUEZ, MARIANA RIBEIRO; ERSCHING, JONATAN; RODRIGUES, MAURICIO MARTINS; VASCONCELOS, JOSE RONNIE. CD8(+) T Cell-Mediated Immunity during Trypanosoma cruzi Infection: A Path for Vaccine Development?. Mediators of Inflammation, v. 2014, p. 12-pg., 2014-01-01. (13/13668-0, 09/06820-4, 12/22514-3)

VASCONCELOS, JOSE RONNIE; BRUNA-ROMERO, OSCAR; ARAUJO, ADRIANO F.; DOMINGUEZ, MARIANA R.; ERSCHING, JONATAN; DE ALENCAR, BRUNA C. G.; MACHADO, ALEXANDRE V.; GAZZINELLI, RICARDO T.; BORTOLUCI, KARINA R.; AMARANTE-MENDES, GUSTAVO P.; et al. Pathogen-Induced Proapoptotic Phenotype and High CD95 (Fas) Expression Accompany a Suboptimal CD8(+) T-Cell Response: Reversal by Adenoviral Vaccine. PLOS PATHOGENS, v. 8, n. 5, p. 16-pg., 2012-05-01. (09/06820-4)