Study in vitro and in vivo of dental implants of Ti-30Ta experimental alloy after biomimetic surface treatment

• Grant number: 10/07231-0
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2010
• End date: July 31, 2012
• Field of knowledge: Interdisciplinary Subjects
• Principal Investigator: Ana Paula Rosifini Alves
• Grantee: Ana Paula Rosifini Alves
• Host Institution: Faculdade de Engenharia (FEG). Universidade Estadual Paulista (UNESP). Campus de Guaratinguetá. Guaratinguetá , SP, Brazil
• Associated researchers: Luis Rogerio de Oliveira Hein ; Maria Cristina Rosifini Alves Rezende ; Mário Jefferson Quirino Louzada ; Sandra Giacomin Schneider

Abstract

This multidisciplinary proposal is innovative and it applies the research developed for our group in the last years since project (2007/00059-4) was approved. The techniques developed would be used for to obtain and to modify the surface of Ti-30Ta alloy. Ingots will be obtained in arc melting furnace, heat treated and cold worked. Dental implants (2mm in diameter and 2.5mm in length) will be machined and submitted to biomimetic surface treatment. Surface treatment of the implants will be realized according with our previous work. Thus, it was divided in three stages: alkali treatment (NaOH), heat treatment and immersion in 5xSBF for 24 hours. Implants will be divided into two groups for surface and osseointegration evaluation. The formation of apatite layer will be observed morphologically by scanning electron microscopy (SEM). Also FTIR, EDS and X-ray diffraction will be used to confirm the presence of apatite-like layer in implants surface. For osseointegration analysis, implants will be placed into the femurs of eight rats, one on the left and the other on the right, treated and no treated, respectively. After healing of 7, 14 and 28 days, animals will be sacrificed through an overdose of CO2 inhalation and femurs will be dissected for histology analysis. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ESCADA, A. L. A.; MACHADO, J. P. B.; SCHNEIDER, S. G.; NAKAZATO, ROBERTO ZENHEI; CLARO, A. P. R. ALVES. Growth of Calcium Phosphate Using Chemically Treated Titanium Oxide Nanotubes. Journal of Nano Research, v. 16, p. 63-68, 2011. (10/07231-0, 10/10174-8)

ESCADA, A. L. A.; MACHADO, J. P. B.; NAKAZATO, ROBERTO ZENHEI; ALVES CLARO, A. P. R.; OCHSNER, A; MURCH, GE; SHOKUHFAR, A; DELGADO, JMPQ. Growth of Calcium Phosphate Coating on Ti-7.5Mo Alloy After Anodic Oxidation. DIFFUSION IN SOLIDS AND LIQUIDS, v. 334-335, p. 2-pg., 2013-01-01. (10/07231-0)

CAPELLATO, PATRICIA; ESCADA, ANA L. A.; POPAT, KETUL C.; ALVES CLARO, ANA P. R.. Interaction between mesenchymal stem cells and Ti-30Ta alloy after surface treatment. Journal of Biomedical Materials Research Part A, v. 102, n. 7, p. 2147-2156, JUL 2014. (10/07231-0)

ESCADA, A. L. A.; MACHADO, J. P. B.; NAKAZATO, ROBERTO ZENHEI; ALVES CLARO, A. P. R.; SALGADO, L; AMBROZIO, F. Obtaining of Nanoapatite in Ti-7.5Mo Surface After Nanotube Growth. Materials Science Forum, v. 727-728, p. 2-pg., 2012-01-01. (10/07231-0)