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Histologic and histomorphometric monitoring of bone healing process around self-drilling orthodontic miniscrews, subjected or not to immediate loading, in rabbit tibiae

Grant number: 10/09422-7
Support type:Regular Research Grants
Duration: September 01, 2010 - August 31, 2012
Field of knowledge:Health Sciences - Dentistry - Orthodontics
Principal researcher:Gladys Cristina Dominguez Morea
Grantee:Gladys Cristina Dominguez Morea
Home Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Orthodontic miniscrews are temporary devices installed during the treatment as skeletal anchorage, which allow orthodontic movements on three spacial plans, favoring the malocclusion correction. The purpose of this study will be describe the initial healing process around self-drilling orthodontic miniscrews, sterilizated by the researchers, subjected or not to immediate loading. A hundred forty four self-drilling orthodontic miniscrews (TOMAS, Dentaurum, Germany) will be inserted in the tibiae of eighteen New Zealand White rabbits. Orthodontic load (50 cN) will be applied immediately after miniscrew insertion, by Remanium® (Dentaurum) closed coil spring between the implant pairs. Four rabbits will be sacrified in each of the four times, days 15, 21, 30 and 60, and two animals will be sacrified on day 0 performing the control group. After these periods of osseointegration, all screws and surrounding bone will be removed and microsections will be prepared. Digital images of hard-tissue around the screw will be captured and analyzed histologically, histomorphometrically and under fluorescent microscopy, for characterization of healing process with and without loading. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CHIBEBE CATHARINO, PRISCILLA CAMPANATTI; DOMINGUEZ, GLADYS CRISTINA; PINTO, JR., DECIO DOS SANTOS; MOREA, CAMILLO. Histologic, Histomorphometric, and Radiographic Monitoring of Bone Healing Around In-Office-Sterilized Orthodontic Mini-implants With or Without Immediate Load: Study in Rabbit Tibiae. INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS, v. 29, n. 2, p. 321-330, . (10/09422-7)

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