Pontine mechanisms involved in cardiorespiratory control during central or peripheral chemoreceptors activation

• Grant number: 10/19336-0
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2011
• End date: June 30, 2013
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Thiago dos Santos Moreira
• Grantee: Thiago dos Santos Moreira
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Pontine nuclei involved in autonomic and respiratory control are the noradrenergic A5 region, intertrigeminal region, parabrachial complex and the Kolliker-Fuse (A7 noradrenergic region). The noradrenergic A5 region is an important region located in the ventrolateral pons that receives several afferents from brainstem neurons involved in cardiorespiratory control. Kolliker-Fuse/A7 noradrenergic region project massively to brainstem respiratoy columm. Both regions are well involved in autonomic regulation like water and sodium intake, gastrointestinal control and cardiorespiratory regulation. In addition, both regions are also involved in the Hering-Breuer reflex and peripheral chemoreflex. Preliminary experiments from our laboratory have shown that A5 or A7 regions have extensively projections to the chemosensitive neurons located in the retrotrapezoid nucleus (RTN). Based on these informations, the aims of the present project are: 1) to evaluate the role of the A5 and A7 regions in cardiorespiratory control at baseline and during central or peripheral chemoreflex activation; 2) to evaluate the role of A5 or A7 noradrenergic neurons in cardiorespiratory control at baseline and during central or peripheral chemoreflex activation and 3) to investigate a possible anatomic pathway between the A5 or A7 noradrenergic neurons and the RTN chemosensitive neurons. (AU)

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DAMASCENO, ROSELIA S.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.. Respiratory and sympathetic chemoreflex regulation by Kolliker-Fuse neurons in rats. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, v. 467, n. 2, p. 231-239, FEB 2015. (10/19336-0, 10/09776-3, 10/15692-7)

TAKAKURA, ANA C.; MOREIRA, THIAGO S.; DE PAULA, PATRICIA M.; MENANI, JOSE V.; COLOMBARI, EDUARDO. Control of breathing and blood pressure by parafacial neurons in conscious rats. Experimental Physiology, v. 98, n. 1, p. 304-315, JAN 2013. (10/19336-0, 10/09776-3, 09/54888-7)

SOBRINHO, CLEYTON R.; WENKER, IAN C.; POSS, ERIN M.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.; MULKEY, DANIEL K.. Purinergic signalling contributes to chemoreception in the retrotrapezoid nucleus but not the nucleus of the solitary tract or medullary raphe. JOURNAL OF PHYSIOLOGY-LONDON, v. 592, n. 6, p. 1309-1323, MAR 15 2014. (10/19336-0, 10/09776-3, 11/13462-7)

BARNA, B. F.; TAKAKURA, A. C.; MOREIRA, T. S.. ACUTE EXERCISE-INDUCED ACTIVATION OF PHOX2B-EXPRESSING NEURONS OF THE RETROTRAPEZOID NUCLEUS IN RATS MAY INVOLVE THE HYPOTHALAMUS. Neuroscience, v. 258, p. 355-363, JAN 31 2014. (10/19336-0, 10/09776-3, 10/12590-9)

TOTOLA, L. T.; ALVES, T. B.; TAKAKURA, A. C.; FERREIRA-NETO, H. C.; ANTUNES, V. R.; MENANI, J. V.; COLOMBARI, E.; MOREIRA, T. S.. COMMISSURAL NUCLEUS OF THE SOLITARY TRACT REGULATES THE ANTIHYPERTENSIVE EFFECTS ELICITED BY MOXONIDINE. Neuroscience, v. 250, p. 80-91, OCT 10 2013. (10/19336-0, 10/09776-3, 09/54888-7, 11/50770-1, 11/11934-9)

TAXINI, C. L.; TAKAKURA, A. C.; GARGAGLIONI, L. H.; MOREIRA, T. S.. CONTROL OF THE CENTRAL CHEMOREFLEX BY A5 NORADRENERGIC NEURONS IN RATS. Neuroscience, v. 199, p. 177-186, DEC 29 2011. (10/15501-7, 10/19336-0, 10/09776-3)

BARNA, B. F.; TAKAKURA, A. C.; MOREIRA, T. S.. PONTOMEDULLARY AND HYPOTHALAMIC DISTRIBUTION OF FOS-LIKE IMMUNOREACTIVE NEURONS AFTER ACUTE EXERCISE IN RATS. Neuroscience, v. 212, p. 120-130, JUN 14 2012. (10/19336-0, 10/09776-3)

WENKER, IAN C.; SOBRINHO, CLEYTON R.; TAKAKURA, ANA C.; MOREIRA, THIAGO S.; MULKEY, DANIEL K.. Regulation of ventral surface CO2/H+-sensitive neurons by purinergic signalling. JOURNAL OF PHYSIOLOGY-LONDON, v. 590, n. 9, p. 2137-2150, MAY 2012. (10/19336-0, 10/09776-3, 11/13462-7)

WENKER, IAN C.; SOBRINHO, CLEYTON R.; TAKAKURA, ANA C.; MULKEY, DANIEL K.; MOREIRA, THIAGO S.. P2Y1 Receptors Expressed by C1 Neurons Determine Peripheral Chemoreceptor Modulation of Breathing, Sympathetic Activity, and Blood Pressure. Hypertension, v. 62, n. 2, p. 263-273, AUG 2013. (10/19336-0, 10/09776-3, 11/13462-7)