Effects of exercise training on structure and cerebral metabolism, cognition and neurovascular control in individuals with obstructive sleep apnea

• Grant number: 10/15064-6
• Support type: Regular Research Grants
• Duration: May 01, 2011 - October 31, 2014
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Linda Massako Ueno Pardi
• Grantee: Linda Massako Ueno Pardi
• Home Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Assoc. researchers: Carlos Alberto Buchpiguel ; Carlos Eduardo Negrão ; Geraldo Busatto Filho ; Geraldo Lorenzi Filho ; Ivani Credidio Trombetta ; Paulo Jannuzzi Cunha

Abstract

Obstructive sleep apnea syndrome (OSA) is characterized by complete or partial collapse of a narrowed pharynx and it's associated with reduction in cerebral blood flow, cardiovascular disease, and neuropsychological deficits and reduces survival. In patients with AOS structural, metabolic and hypoperfusion cerebral were associated not only with physiological functions but also with attention and executive function. There is a higher association between apnea hypopnea index and Mini-Mental State Examination in individuals with the exon 4 of APO E gene, indicating that exon 4 of APO E gene confers an increased risk for cognitive decline in individuals with sleep apnea. The analysis of presence and consequences of OSA in cerebral structure, inflammation and neurovascular control can permit a better investigation of abnormalities in these individuals and implement interventions to reduce the risk of development of cognitive and cardiovascular impairment. The non-pharmacological intervention through exercise training can represent an important strategy for improvement in cerebral alterations, cognition and reduction in sleep apnea index. The purpose of present study is investigate the volume and metabolism cerebral, neurovascular control, cognition and exon 4 of APOE gene and their associations before and after exercise training in individuals with moderate to severe OSA. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GUERRA, RENAN S.; GOYA, THIAGO T.; SILVA, ROSYVALDO F.; LIMA, MARTA F.; BARBOSA, ELINE R. F.; ALVES, MARIA JANIEIRE DE N. N.; RODRIGUES, AMANDA G.; LORENZI-FILHO, GERALDO; NEGRAO, CARLOS EDUARDO; UENO-PARDI, LINDA M. Exercise Training Increases Metaboreflex Control in Patients with Obstructive Sleep Apnea. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 51, n. 3, p. 426-435, MAR 2019. Web of Science Citations: 0.

FERREIRA-SILVA, ROSYVALDO; GOYA, THIAGO T.; BARBOSA, ELINE R. F.; DURANTE, BRUNO G.; ARAUJO, CARLOS E. L.; LORENZI-FILHO, GERALDO; UENO-PARDI, LINDA M. Vascular Response During Mental Stress in Sedentary and Physically Active Patients With Obstructive Sleep Apnea. JOURNAL OF CLINICAL SLEEP MEDICINE, v. 14, n. 9, p. 1463-1470, 2018. Web of Science Citations: 0.

UENO-PARDI, LINDA M.; GUERRA, RENAN S.; GOYA, THIAGO T.; SILVA, ROSYVALDO F.; GARA, ELISANGELA M.; LIMA, MARTA F.; NOBRE, THAIS S.; ALVES, MARIA J. N. N.; TROMBETTA, IVANI C.; LORENZI-FILHO, GERALDO. Muscle Metaboreflex Control of Sympathetic Activity in Obstructive Sleep Apnea. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 49, n. 7, p. 1424-1431, JUL 2017. Web of Science Citations: 2.

GOYA, THIAGO T.; SILVA, ROSYVALDO F.; GUERRA, RENAN S.; LIMA, MARTA F.; BARBOSA, ELINE R. F.; CUNHA, PAULO JANNUZZI; LOBO, DENISE M. L.; BUCHPIGUEL, CARLOS A.; BUSATTO-FILHO, GERALDO; NEGRAO, CARLOS E.; LORENZI-FILHO, GERALDO; UENO-PARDI, LINDA M. Increased Muscle Sympathetic Nerve Activity and Impaired Executive Performance Capacity in Obstructive Sleep Apnea. Sleep, v. 39, n. 1, p. 25-33, JAN 1 2016. Web of Science Citations: 9.