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Exercise, pollution and the brain: influence on sleep and cognition

Grant number: 13/05018-5
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): August 01, 2013
Effective date (End): February 26, 2015
Field of knowledge:Health Sciences - Physical Education
Principal researcher:Marco Túlio de Mello
Grantee:Ricardo Cardoso Cassilhas
Home Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Federal de São Paulo (UNIFESP). Campus São José dos Campos. São José dos Campos , SP, Brazil


The purpose of this project is to examine the possible protective value of exercise compared to the negative elements of particulate matter (PM) exposure shown in elderly sedentary individuals on brain function, cognition, and sleep disordered breathing (SDB). The results of this project will give novel insights into the mechanisms why exercise is good for brain health even when cognition is threatened by chronic exposure to pollution. Chronic exposure to pollution is responsible for increased risk of SDB and nocturnal hypoxemia. SDB reduces significantly sleep quality, and has been associated with hypertension, coronary artery disease, stroke, congestive heart failure, and arrhythmias as well as cognitive decline in older adults We will be performing a an intervention study will answer the following questions: if chronic training has a positive effect on brain health, and if exercise will have a protective effect on the cognitive decline, and sleep disturbances normally seen in individuals who live in polluted areas, compared to those living in a 'clean' area? (AU)

News published in Agência FAPESP Newsletter about the scholarship:

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CASSILHAS, RICARDO C.; TUFIK, SERGIO; DE MELLO, MARCO TULIO. Physical exercise, neuroplasticity, spatial learning and memory. CELLULAR AND MOLECULAR LIFE SCIENCES, v. 73, n. 5, p. 975-983, MAR 2016. Web of Science Citations: 28.
ANDRADE E SILVA, BRUNA; CASSILHAS, RICARDO C.; ATTUX, CECILIA; CORDEIRO, QUIRINO; GADELHA, ANDRE L.; TELLES, BRUNO A.; BRESSAN, RODRIGO A.; FERREIRA, FRANCINE N.; RODSTEIN, PAULO H.; DALTIO, CLAUDIANE S.; TUFIK, SERGIO; DE MELLO, MARCO T. A 20-week program of resistance or concurrent exercise improves symptoms of schizophrenia: results of a blind, randomized controlled trial. Revista Brasileira de Psiquiatria, v. 37, n. 4, p. 271-279, OCT-DEC 2015. Web of Science Citations: 17.

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