Exercise, pollution and the brain: influence on sleep and cognition

• Grant number: 13/05018-5
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: August 01, 2013
• End date: February 26, 2015
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Marco Túlio de Mello
• Grantee: Ricardo Cardoso Cassilhas
• Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Federal de São Paulo (UNIFESP). Campus São José dos Campos. São José dos Campos , SP, Brazil

Abstract

The purpose of this project is to examine the possible protective value of exercise compared to the negative elements of particulate matter (PM) exposure shown in elderly sedentary individuals on brain function, cognition, and sleep disordered breathing (SDB). The results of this project will give novel insights into the mechanisms why exercise is good for brain health even when cognition is threatened by chronic exposure to pollution. Chronic exposure to pollution is responsible for increased risk of SDB and nocturnal hypoxemia. SDB reduces significantly sleep quality, and has been associated with hypertension, coronary artery disease, stroke, congestive heart failure, and arrhythmias as well as cognitive decline in older adults We will be performing a an intervention study will answer the following questions: if chronic training has a positive effect on brain health, and if exercise will have a protective effect on the cognitive decline, and sleep disturbances normally seen in individuals who live in polluted areas, compared to those living in a 'clean' area? (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ANDRADE E SILVA, BRUNA; CASSILHAS, RICARDO C.; ATTUX, CECILIA; CORDEIRO, QUIRINO; GADELHA, ANDRE L.; TELLES, BRUNO A.; BRESSAN, RODRIGO A.; FERREIRA, FRANCINE N.; RODSTEIN, PAULO H.; DALTIO, CLAUDIANE S.; et al. A 20-week program of resistance or concurrent exercise improves symptoms of schizophrenia: results of a blind, randomized controlled trial. Revista Brasileira de Psiquiatria, v. 37, n. 4, p. 271-279, OCT-DEC 2015. (13/05018-5)

CASSILHAS, RICARDO C.; TUFIK, SERGIO; DE MELLO, MARCO TULIO. Physical exercise, neuroplasticity, spatial learning and memory. CELLULAR AND MOLECULAR LIFE SCIENCES, v. 73, n. 5, p. 975-983, MAR 2016. (13/05018-5)

CASSILHAS, RICARDO CARDOSO; DE SOUSA, RICARDO AUGUSTO LEONI; CAXA, LUCIANA; VIANA, VALTER; MEEUSEN, ROMAIN; GONCALVES, FABIO LUIZ; MAGALHAES, CAIQUE OLEGARIO; TUFIK, SERGIO; DIAS PEIXOTO, MARCO FABRICIO; MONTEIRO JUNIOR, RENATO SOBRAL; et al. ndoor aerobic exercise reduces exposure to pollution, improves cognitive function, and enhances BDNF levels in the elderl. AIR QUALITY ATMOSPHERE AND HEALTH, v. 15, n. 1, AUG 2021. (13/05018-5)