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Assessment of strategies to manage dental erosion caused by endogenous and exogenous acid sources

Grant number: 11/02533-0
Support type:Regular Research Grants
Duration: August 01, 2011 - July 31, 2013
Field of knowledge:Health Sciences - Dentistry - Dental Clinics
Principal Investigator:Cecilia Pedroso Turssi
Grantee:Cecilia Pedroso Turssi
Home Institution: Centro de Pesquisas Odontológicas São Leopoldo Mandic. Faculdade São Leopoldo Mandic (SLMANDIC). Sociedade Regional de Ensino e Saúde S/S Ltda (SRES). Campinas , SP, Brazil
Assoc. researchers:Anderson Takeo Hara ; Fabiana Mantovani Gomes França ; Flavia Lucisano Botelho Do Amaral ; Roberta Tarkany Basting Höfling


Strategies to manage erosion involve actions that are aimed at enhancing the acid resistance and dental remineralization and at providing the neutralization of acids present in the oral cavity. However, it is still limited the knowledge regarding agents that could potentially exert such effects. Therefore, this proposal, composed by 2 projects, has the following aims 1) assess whether rinsing a calcium lactate solution (LacCa) used prior to a fluoride solution (F) would reduce wear and demineralization of enamel exposed to an exogenous acid (citric acid) and; 2) verify whether neutralizing oral suspensions (antiacids) could minimize the wear and demineralization caused by a chloridric acid solution, which simulates acids from endogenous origin. To reach that, one in situ protocol and one in vitro study will be carried out, using bovine enamel. In the in situ model, structured according to a crossover design, 14 volunteers Will rinse LacCa + F or F only, for 10 days, in an independent and alternate fashion, prior to acid challenges performed with citric acid. In the in vitro study, enamel slabs Will be exposed to chloridric acid, simulating the contact of teeth with the gastric content following an emesis episode, and then neutralizing agents composed by magnesium hydroxide and/or aluminum hydroxide, sodium alginate + sodium bicarbonate + calcium carbonate or hydrated aluminum magnesium sulphate will be applied. For both investigations, microhardness and wear will be evaluated. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TURSSI, CECILIA P.; HARA, ANDERSON T.; AMARAL, FLAVIA L. B.; FRANCA, FABIANA M. G.; BASTING, ROBERTA T. Calcium lactate pre-rinse increased fluoride protection against enamel erosion in a randomized controlled in situ trial. Journal of Dentistry, v. 42, n. 5, p. 534-539, MAY 2014. Web of Science Citations: 6.
TURSSI, CECILIA P.; VIANNA, LIDIA M. F. F.; HARA, ANDERSON T.; DO AMARAL, FLAVIA L. B.; FRANCA, FABIANA M. G.; BASTING, ROBERTA T. Counteractive effect of antacid suspensions on intrinsic dental erosion. European Journal of Oral Sciences, v. 120, n. 4, p. 349-352, AUG 2012. Web of Science Citations: 11.

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