| Grant number: | 10/51454-3 |
| Support Opportunities: | Research Projects - Thematic Grants |
| Start date: | August 01, 2011 |
| End date: | July 31, 2017 |
| Field of knowledge: | Biological Sciences - Botany |
| Principal Investigator: | Beatriz Appezzato da Glória |
| Grantee: | Beatriz Appezzato da Glória |
| Host Institution: | Escola Superior de Agricultura Luiz de Queiroz (ESALQ). Universidade de São Paulo (USP). Piracicaba , SP, Brazil |
| City of the host institution: | Piracicaba |
| Pesquisadores principais: (Últimos): | Fernando Batista da Costa |
| Associated scholarship(s): | 14/01707-3 - Metabolomic analysis of the bioactivity in COX and LOX pathways-dependent of plants from subtribe Lychnophorinae,
BP.MS 12/16646-4 - Metabolomics and screening of plant-insect interactions of plants from the subtribe Lychnophorinae (Asteraceae), BP.DR 12/10249-3 - Chemometrics applied to metabolomics of Aldama La Llave: chemotaxonomic contributions and targeted phytochemistry based on cyclooxygenase-1 and 5-lipoxygenase inhibition, BP.MS |
Abstract
The thematic project is organized in three subprojects whose main goal is to broaden metabolomic and morphoanatomical knowledge of Asteraceae clarifying the phylogeny of two major groups, besides investigating the pharmacological potential of the species through in vitro bioassays. The choice of Heliantheae and Vemonieae tribes was based on the fact that they are quite representative groups in Brazil in two very distinct branches within Asteraceae. Many of the species are endemic, occurring in Cerrado areas, and at risk of being wiped out before biological and chemical studies are carried out. Viguiera Kunth. (Heliantheae tribe) was chosen since it has a high number of species, complex taxonomic classification and problems of delimitation. A taxonomic revision of the species occurring in Brazil was held in 2006 by Prof. Mara Magenta, who pointed out the need for studies using molecular markers associated with morphoanatomical and chemical studies to understand the phylogeny of this group. From the tribe Vernonieae species of the subtribe Lychnophorinae and a related monospecific genus, considered the sister group of Lychnophorinae, were selected. The choice was based on preliminary results of molecular phylogeny and the difficulty to design phylogenetic group by doctorate Benoit Loeuille under the supervision of Prof. Jose R. Pirani. The search for new chemical compounds from plants in major Brazilian biomes like Cerrado for their use in the treatment of diseases can contribute to the sustainability of the country, which could generate income in small communities of less-favored regions where the species listed in this project grow and develop. (AU)
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