Neural mechanisms involved of hydroelectrolytic balance and cardiorespiratory control

• Grant number: 11/50770-1
• Support Opportunities: Research Projects - Thematic Grants
• Start date: April 01, 2012
• End date: May 31, 2016
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Agreement: CNPq - Pronex
• Principal Investigator: José Vanderlei Menani
• Grantee: José Vanderlei Menani
• Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Pesquisadores principais: Eduardo Colombari ; Laurival Antonio de Luca Junior
• Associated research grant(s): 13/02607-0 - AAA - Annual Meeting at Experimental Biology 2013, AR.EXT
• Associated scholarship(s): 15/08246-4 - Neural mechanisms involved of hydroelectrolytic balance and cardiorespiratory control, BP.IC; 14/01159-6 - Role of reactive oxygen species (ROS) within the NTS on development and maintenance of hypertension on 2 kidney-1 clip renovascular, BP.DR; 14/02271-4 - Neural mechanisms of hydroelectrolytic balance and cardiorespiratory control regulation, BP.PD; + associated scholarships 13/13118-0 - Role of the melanocortin system and the renin-angiotensin system on cardiorespiratory changes in rats fed with high fat diet, BP.DR; 13/05189-4 - Involvement of oxidative stress and pro-inflammatory cytokines in hypertension, BP.DD; 13/00026-0 - Characterization of aldosterone action on hindbrain on the hydroeletrolytic control and cardiovascular regulation, BP.PD; 10/20407-0 - Interaction between facilitatory mechanisms and lateral parabrachial nucleus mechanisms in the control of sodium intake and oxytocin secretion, BP.DR - associated scholarships

Abstract

The objective of the Project is to elucidate neural mechanisms that process autonomic information associated with compensatory cardiovascular, respiratory and behavioral (thirst and sodium appetite) adjustments to dehydration and underlying arterial hypertension. The study will focus on a model circuit involving a triangle formed by nucleus of the solitary tract (NTS), rostro-ventrolateral medullary region (RVL) and lateral parabrachial nucleus (NPBL) and their connections with forebrain regions such as lamina terminalis and nucleus accumbens. To reach this aim the project combines diverse techniques such as: intraencephalic chemical injections; viral transfection; immunohistochemistry; electrophysiology; behavioral, cardiovascular and respiratory recordings. The expectation is to answer questions such as: 1. What is the pathway activated by osmorrecception to inhibit and activate sodium intake? 2. What mechanisms forebrain circuits use to process information coming from NPBL linked to the control of sodium intake? 3. In what mechanisms linking hindbrain to forebrain does angiotensin II act to control arterial pressure? 4. How is cardiorespiratory transduction performed in the NTS, RVL or NPBL? (AU)

Scientific publications

(20)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BLANCH, GRAZIELA TORRES; FREIRIA-OLIVEIRA, ANDRE HENRIQUE; FINA SPERETTA, GUILHERME FLEURY; CARRERA, EDUARDO J.; LI, HONGWEI; SPETH, ROBERT C.; COLOMBARI, EDUARDO; SUMNERS, COLIN; COLOMBARI, DEBORA S. A.. Increased Expression of Angiotensin II Type 2 Receptors in the Solitary-Vagal Complex Blunts Renovascular Hypertension. Hypertension, v. 64, n. 4, p. 777+, OCT 2014. (11/50770-1)

GASPARINI, S.; MELO, M. R.; LEITE, G. F.; NASCIMENTO, P. A.; ANDRADE-FRANZE, G. M. F.; MENANI, J. V.; COLOMBARI, E.. RAPID STIMULATION OF SODIUM INTAKE COMBINING ALDOSTERONE INTO THE 4TH VENTRICLE AND THE BLOCKADE OF THE LATERAL PARABRACHIAL NUCLEUS. Neuroscience, v. 346, p. 94-101, MAR 27 2017. (13/00026-0, 15/23467-7, 11/50770-1)

GREENWOOD, MINGKWAN; BORDIERI, LOREDANA; GREENWOOD, MICHAEL P.; MELO, MARIANA ROSSO; COLOMBARI, DEBORA S. A.; COLOMBARI, EDUARDO; PATON, JULIAN F. R.; MURPHY, DAVID. Transcription Factor CREB3L1 Regulates Vasopressin Gene Expression in the Rat Hypothalamus. JOURNAL OF NEUROSCIENCE, v. 34, n. 11, p. 3810-3820, MAR 12 2014. (11/50770-1)

SPERETTA, GUILHERME F.; SILVA, ANDRE A.; VENDRAMINI, REGINA C.; ZANESCO, ANGELINA; DELBIN, MARIA A.; MENANI, JOSE V.; BASSI, MIRIAN; COLOMBARI, EDUARDO; COLOMBARI, DEBORA S. A.. Resistance training prevents the cardiovascular changes caused by high-fat diet. Life Sciences, v. 146, p. 154-162, FEB 1 2016. (13/13118-0, 11/50770-1)

PEREIRA-DERDERIAN, DANIELA T. B.; VENDRAMINI, REGINA C.; MENANI, JOSE V.; CHIAVEGATTO, SILVANA; DE LUCA, JR., LAURIVAL A.. Water deprivation-partial rehydration induces sensitization of sodium appetite and alteration of hypothalamic transcripts. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, v. 310, n. 1, p. R15-R23, JAN 1 2016. (11/50770-1, 09/01333-8)

SANTOS, B. M.; DAVID, R. B.; ANDRADE, C. A. F.; VENDRAMINI, R.; HURLEY, S.; MENANI, J., V; JOHNSON, A. K.; DE LUCA JR, L. A.. Reciprocal interactions between sodium appetite and need-free sugar intake. APPETITE, v. 155, p. 9-pg., 2020-12-01. (11/50770-1)

GASPARINI, S.; MELO, M. R.; NASCIMENTO, P. A.; ANDRADE-FRANZE, G. M. F.; ANTUNES-RODRIGUES, J.; YOSTEN, G. L. C.; MENANI, J. V.; SAMSON, W. K.; COLOMBARI, E.. Interaction of central angiotensin II and aldosterone on sodium intake and blood pressure. Brain Research, v. 1720, OCT 1 2019. (13/00026-0, 11/50770-1)

RONCARI, CAMILA F.; BARBOSA, RAFAELA M.; VENDRAMINI, REGINA C.; DE LUCA, JR., LAURIVAL A.; MENANI, JOSE V.; COLOMBARI, EDUARDO; COLOMBARI, DEBORA S. A.. Enhanced angiotensin II induced sodium appetite in renovascular hypertensive rats. Peptides, v. 101, p. 82-88, MAR 2018. (15/23467-7, 11/50770-1)

DE LUCA, JR., LAURIVAL A.; ALMEIDA, ROBERTO L.; DAVID, RICHARD B.; DE PAULA, PATRICIA M.; ANDRADE, CARINA A. F.; MENANI, JOSE V.. Participation of alpha(2)-adrenoceptors in sodium appetite inhibition during sickness behaviour following administration of lipopolysaccharide. JOURNAL OF PHYSIOLOGY-LONDON, v. 594, n. 6, p. 1607-1616, MAR 15 2016. (03/09857-0, 11/50770-1)

SANTOS, BRUNA M.; DE ANDRADE, CARINA A. F.; MENANI, JOSE V.; DE LUCA, JR., LAURIVAL A.. Short-term cross-sensitizion of need-free sugar intake by combining sodium depletion and hypertonic NaCl intake. APPETITE, v. 107, p. 79-85, DEC 1 2016. (11/50770-1, 11/23696-5)

RUCHAYA, PRASHANT J.; SPERETTA, GUILHERME F.; BLANCH, GRAZIELA TORRES; LI, HONGWEI; SUMNERS, COLIN; MENANI, JOSE V.; COLOMBARI, EDUARDO; COLOMBARI, DEBORA S. A.. Overexpression of AT2R in the solitary-vagal complex improves baroreflex in the spontaneously hypertensive rat. Neuropeptides, v. 60, p. 29-36, DEC 2016. (11/50770-1)

DA SILVA, ELAINE FERNANDA; BASSI, MIRIAN; MENANI, JOSE VANDERLEI; ALMEIDA COLOMBARI, DEBORA SIMOES; ZOCCAL, DANIEL BRESEGHELLO; PEDRINO, GUSTAVO RODRIGUES; COLOMBARI, EDUARDO. Carotid bodies contribute to sympathoexcitation induced by acute salt overload. Experimental Physiology, v. 104, n. 1, p. 15-27, JAN 2019. (11/50770-1, 13/17251-6, 15/23467-7)

ANDRADE-FRANZE, GLAUCIA M. F.; ANDRADE, CARINA A. F.; GASPARINI, SILVIA; DE LUCA, JR., LAURIVAL A.; DE PAULA, PATRICIA M.; COLOMBARI, DEBORA S. A.; COLOMBARI, EDUARDO; MENANI, JOSE V.. Importance of the central nucleus of the amygdala on sodium intake caused by deactivation of lateral parabrachial nucleus. Brain Research, v. 1625, p. 238-245, NOV 2 2015. (11/50770-1)

DAVID, RICHARD B.; RONCARI, CAMILA F.; LAUAR, MARIANA R.; VENDRAMINI, REGINA C.; ANTUNES-RODRIGUES, JOSE; MENANI, JOSE V.; DE LUCA, JR., LAURIVAL A.. Sodium intake, brain c-Fos protein and gastric emptying in cell-dehydrated rats treated with methysergide into the lateral parabrachial nucleus. Physiology & Behavior, v. 151, p. 111-120, NOV 1 2015. (11/50770-1, 10/20407-0, 13/05189-4)

RONCARI, C. F.; DAVID, R. B.; JOHNSON, R. F.; DE PAULA, P. M.; COLOMBARI, D. S. A.; DE LUCA, L. A.; JOHNSON, A. K.; COLOMBARI, E.; MENANI, J. V.. ANGIOTENSINERGIC AND CHOLINERGIC RECEPTORS OF THE SUBFORNICAL ORGAN MEDIATE SODIUM INTAKE INDUCED BY GABAergic ACTIVATION OF THE LATERAL PARABRACHIAL NUCLEUS. Neuroscience, v. 262, p. 1-8, MAR 14 2014. (11/50770-1)

TOTOLA, L. T.; ALVES, T. B.; TAKAKURA, A. C.; FERREIRA-NETO, H. C.; ANTUNES, V. R.; MENANI, J. V.; COLOMBARI, E.; MOREIRA, T. S.. COMMISSURAL NUCLEUS OF THE SOLITARY TRACT REGULATES THE ANTIHYPERTENSIVE EFFECTS ELICITED BY MOXONIDINE. Neuroscience, v. 250, p. 80-91, OCT 10 2013. (10/19336-0, 10/09776-3, 09/54888-7, 11/50770-1, 11/11934-9)

FREIRIA-OLIVEIRA, ANDRE HENRIQUE; BLANCH, GRAZIELA TORRES; LI, HONGWEI; COLOMBARI, EDUARDO; ALMEIDA COLOMBARI, DEBORA SIMOES; SUMNERS, COLIN. Macrophage migration inhibitory factor in the nucleus of solitary tract decreases blood pressure in SHRs. Cardiovascular Research, v. 97, n. 1, p. 153-160, JAN 1 2013. (10/09250-1, 11/50770-1)

BARBOSA, RAFAELA MOREIRA; SPERETTA, GUILHERME F.; MARTINS DIAS, DANIEL PENTEADO; RUCHAYA, PRASHANT JAY; LI, HONGWEI; MENANI, JOSE VANDERLEI; SUMNERS, COLIN; COLOMBARI, EDUARDO; COLOMBARI, DEBORA S. A.. Increased Expression of Macrophage Migration Inhibitory Factor in the Nucleus of the Solitary Tract Attenuates Renovascular Hypertension in Rats. AMERICAN JOURNAL OF HYPERTENSION, v. 30, n. 4, p. 435-443, APR 2017. (15/23467-7, 11/50770-1)

ZENATTI, A. A.; PEREIRA JR, E. D.; POSSARI, J.; ANDRADE, C. A. F.; MENANI, V, J.; DE LUCA JR, L. A.. Interference with the renin-angiotensin system reduces the palatability of 0.3 M NaCl in sodium-deplete rats. APPETITE, v. 158, MAR 1 2021. (15/23467-7, 11/50770-1, 19/01220-0, 15/20500-3)

RODRIGUES FERNANDES, NATALIE APARECIDA; SANTOS, BRUNA MAITAN; FABRICIO DE ANDRADE-FRANZE, GLAUCIA MARIA; DE PAULA, PATRICIA MARIA; FABRICIO DE ANDRADE, CARINA APARECIDA; MENANI, JOSE VANDERLEI; DE LUCA JR, LAURIVAL ANTONIO. Rapid onset sodium appetite and orofacial responses to intraoral capsaicin and hypertonic NaCl in the rat. APPETITE, v. 174, p. 6-pg., 2022-04-09. (15/20500-3, 11/50770-1)